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Resource for Integrated Glycotechnology

Award Number: P41GM103390
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/1997
PERIOD OF PERFORMANCE END DATE: 01/31/2021

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Resource for Integrated Glycotechnology - DESCRIPTION (provided by applicant): The primary Overall objective of the Resource for Integrated Glycotechnology is to develop novel, integrated technologies and multidisciplinary approaches to solve key problems in glycobiology. Protein-carbohydrate interactions play critical roles in numerous biological recognition events at the cell surface and extracellular matrix. The focus of our studies are proteoglycans (PGs), where extended, linear, charged glycan polymers are attached to cell surface or secreted proteins that contribute to cell-cell, cell-macromolecule, and cell-matrix interactions and influence numerous biological functions. Studies on protein-PG interactions are a prototype for more generalized studies on protein-carbohydrate interactions. Despite the critical importance of PGs in diverse biological processes, very little is known about the details of PG interactions with binding partners or their mechanisms of biological function. As a result, PG-protein interactions are a major technical frontier for contemporary biology. We will address the challenges of PG structures, interactions, and biological functions by leveraging advances in analytical, synthetic, structural, biochemical and biological tools. Technology Research and Development (TR&D) projects will be applied to the study of several Driving Biomedical Projects (DBPs) that will act as a test beds for the utility of the integrated approaches and provide feedback for new challenges that will spur further technology development. As the technologies mature they will be applied to a collection of Collaborative Projects and use in Analytical Services (C&S) that will also extend the utility of the technologies to a broader scientific community. Multiple strategies for Dissemination will increase awareness and access to the technology developments and our Training courses (D&T) will provide direct opportunities for researchers to learn the latest technology developments from Resource staff. The proposal aims to develop technologies (TR&Ds) to advance the goals of the DBPs through ligand identification and validation using PG fragment enrichment approaches, MS-based sequencing and composition analysis, and chemical glycan oligomer synthesis and array generation. Structures of PG-protein complexes will be determined using novel NMR methods and oxidative footprinting approaches and computational methods will predict and validate structure models. Biochemical targets will be generated in large quantities with isotopic labels and further modified to contain paramagnetic tags as needed to facilitate NMR studies. PG core proteins containing engineered glycan polymers will be generated using recombinant expression and cell systems harboring enhanced or mutant PG biosynthetic machinery. Mutant cell lines will also be used to characterize biological functions of PGs in appropriate biological contexts. The combined technology developments will advance our understanding of these critical glycan polymer structures and provide insights into their roles in human physiology and disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = -$20 )
2021	2019	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Biomedical Research and Research Training	000	30	8/11/2021	NON-COMPETING CONTINUATION	-$20
														Subtotal = -$20

Issue Date FY: 2019 ( Subtotal = $1,611,446 )
2019	2019	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Biomedical Research and Research Training	000	30	1/30/2019	NON-COMPETING CONTINUATION	$1,611,446
														Subtotal = $1,611,446

Issue Date FY: 2018 ( Subtotal = $1,612,371 )
2018	2018	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Biomedical Research and Research Training	000	29	2/6/2018	NON-COMPETING CONTINUATION	$1,451,134
2018	2018	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Biomedical Research and Research Training	001	29	4/25/2018	NON-COMPETING CONTINUATION	$161,237
														Subtotal = $1,612,371

Issue Date FY: 2017 ( Subtotal = $1,612,371 )
2017	2017	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Biomedical Research and Research Training	000	28	1/19/2017	NON-COMPETING CONTINUATION	$1,451,134
2017	2017	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Biomedical Research and Research Training	001	28	6/8/2017	NON-COMPETING CONTINUATION	$161,237
														Subtotal = $1,612,371

Issue Date FY: 2016 ( Subtotal = $1,847,371 )
2016	2016	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC	BUSINESS SERVICES BUILDING	ATHENS	GA	30602	CLARKE	USA	Biomedical Research and Research Training	000	27	2/11/2016	NON-COMPETING CONTINUATION	$1,847,371
														Subtotal = $1,847,371

Issue Date FY: 2015 ( Subtotal = $2,374,150 )
2015	2015	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC	BUSINESS SERVICES BUILDING	ATHENS	GA	30602	CLARKE	USA	Biomedical Research and Research Training	001	26	3/31/2015	COMPETING CONTINUATION	$2,374,150
2015	2014	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC	BUSINESS SERVICES BUILDING	ATHENS	GA	30602	CLARKE	USA	Biomedical Research and Research Training	000	25	3/26/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,374,150

Issue Date FY: 2014 ( Subtotal = $1,594,854 )
2014	2014	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC	BUSINESS SERVICES BUILDING	ATHENS	GA	30602	CLARKE	USA	Biomedical Research and Research Training	000	25	3/17/2014	NON-COMPETING CONTINUATION	$1,594,854
														Subtotal = $1,594,854

Issue Date FY: 2013 ( Subtotal = $1,915,239 )
2013	2013	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC	BUSINESS SERVICES BUILDING	ATHENS	GA	30602	CLARKE	USA	Biomedical Research and Research Training	000	24	2/4/2013	NON-COMPETING CONTINUATION	$1,786,234
2013	2013	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC	BUSINESS SERVICES BUILDING	ATHENS	GA	30602	CLARKE	USA	Biomedical Research and Research Training	001	24	6/12/2013	NON-COMPETING CONTINUATION	$129,005
														Subtotal = $1,915,239

Issue Date FY: 2012 ( Subtotal = $1,975,106 )
2012	2012	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC	BUSINESS SERVICES BUILDING	ATHENS	GA	30602	CLARKE	USA	Biomedical Research and Research Training	000	23	3/16/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,485,254
2012	2012	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC	BUSINESS SERVICES BUILDING	ATHENS	GA	30602	CLARKE	USA	Biomedical Research and Research Training	001	23	5/2/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$489,852
														Subtotal = $1,975,106

Grand Total All Awards = $14,542,888

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Resource for Integrated Glycotechnology

Award Number: P41GM103390

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/1997

PERIOD OF PERFORMANCE END DATE: 01/31/2021

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