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Center for Molecular Imaging Technology & Translation (CMITT)

Award Number: P41EB022544
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2017
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Center for Molecular Imaging Technology & Translation (CMITT) - Project Summary / Abstract for the Center for Molecular Imaging Technology and Translation The Center for Molecular Imaging Technology and Translation (CMITT) is a National Center for Biomedical Imaging and Bioengineering located within the Gordon Center for Medical Imaging (GCMI) at the Massachusetts General Hospital. Working within the interdisciplinary environment (e.g., imaging and data sciences; image reconstruction, processing and AI; pharmacokinetics; radiochemistry) of the Gordon Center, the aim of the CMITT is to develop, validate and disseminate cutting-edge imaging technologies that take advantage of the game-changing capabilities afforded by simultaneous acquisition of PET and MR. CMITT approaches PET/MR as a truly synergistic modality, with novel radiochemistry, kinetic modeling, quantitative methods, image reconstruction and AI that exploit properties of PET and MR signals. Thus CMITT advances the methodology of PET/MR and covers the entire range of radiochemistry/radiopharmacy to image formation and processing including tomographic reconstruction and estimation/quantitation, paving the way for research applications and clinical translation. Our pioneering work during the initial funding cycle, Y1-4, of our P41 in quantitative PET/MR, has provided solutions to some of the most vexing problems affecting PET/MR, including reliable and accurate corrections for attenuation and involuntary subject motion (TR&D 1 in Y1-4). We have provided unique contributions to PET quantitation and image reconstruction by using deep learning (TR&D 2 in Y1-4). We have also advanced novel radioligands and new molecular measurements, starting from first concept to actual application (TR&D 3 in Y1-4). Accordingly, in this renewal application, we are in a strong position to propose and develop new field-leading technologies pertaining to Molecular Imaging using PET and MR. The TR&D1 of the renewal develops and delivers multi-parametric quantitative PET/MR imaging technologies that not only enable physiological high-impact novel PET/MR but will also benefit standalone MR research. The TR&D2 of the renewal develops an innovative artificial intelligence-based pipeline of data processing in PET/MR, including image reconstruction, transfer learning, and uncertainty estimation. The TR&D3 of the renewal uses the developments achieved in TR&Ds 1&2 to translate applications of PET/MR from physiological concept to measurements in animal models and then on to first-in-human studies. The National Resource provides a unique environment with an interdisciplinary team of highly accomplished scientists, engineers, and clinicians with diverse expertise in multiple modalities and disciplines that supports service use of the Center's facilities by imaging scientists throughout the country as well as Canada and Australia. CMITT will provide extensive training opportunities for students, post-doctoral fellows, and faculty, and seeks to advance the field of molecular imaging of normal function and disease through active dissemination of new knowledge and technology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	8	11/28/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	7	2/14/2025	SUPPLEMENT FOR EXPANSION	$0
2025	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	004	8	4/21/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2025	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	8	2/14/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,166,370
2025	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	8	4/10/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2025	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	7	2/14/2025	NON-COMPETING CONTINUATION	-$878,276
2025	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	7	2/14/2025	SUPPLEMENT FOR EXPANSION	-$288,094
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,339,345 )
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	8	8/30/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,339,345
2024	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	7	8/30/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,339,345

Issue Date FY: 2023 ( Subtotal = $1,687,391 )
2023	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	7	8/17/2023	NON-COMPETING CONTINUATION	$1,270,605
2023	2023	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	004	7	8/22/2023	SUPPLEMENT FOR EXPANSION	$416,786
2023	2022	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	6	1/18/2023	COMPETING CONTINUATION	$965,001
2023	2021	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	1/18/2023	NON-COMPETING CONTINUATION	-$756,035
2023	2021	THE GENERAL HOSPITAL CORPORATION	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	5	1/18/2023	SUPPLEMENT FOR EXPANSION	-$208,965
														Subtotal = $1,687,391

Issue Date FY: 2022 ( Subtotal = $1,510,674 )
2022	2022	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	6	6/22/2022	COMPETING CONTINUATION	$1,510,674
														Subtotal = $1,510,674

Issue Date FY: 2021 ( Subtotal = $1,519,178 )
2021	2021	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	5	9/15/2021	NON-COMPETING CONTINUATION	$1,190,209
2021	2021	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	5	9/16/2021	SUPPLEMENT FOR EXPANSION	$328,969
2021	2020	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	11/16/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,519,178

Issue Date FY: 2020 ( Subtotal = $1,515,022 )
2020	2020	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	4	9/15/2020	SUPPLEMENT FOR EXPANSION	$300,523
2020	2020	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	9/14/2020	NON-COMPETING CONTINUATION	$1,214,499
														Subtotal = $1,515,022

Issue Date FY: 2019 ( Subtotal = $1,536,531 )
2019	2019	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	9/5/2019	NON-COMPETING CONTINUATION	$1,215,152
2019	2019	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	9/21/2019	SUPPLEMENT FOR EXPANSION	$321,379
														Subtotal = $1,536,531

Issue Date FY: 2018 ( Subtotal = $1,506,175 )
2018	2018	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	7/13/2018	NON-COMPETING CONTINUATION	$1,215,152
2018	2018	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Aging Research	001	2	9/1/2018	SUPPLEMENT FOR EXPANSION	$291,023
														Subtotal = $1,506,175

Issue Date FY: 2017 ( Subtotal = $1,650,398 )
2017	2017	MASSACHUSETTS GENERAL HOSPITAL, THE	55 FRUIT ST	BOSTON	MA	02114	SUFFOLK	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/22/2017	NEW	$1,650,398
														Subtotal = $1,650,398

Grand Total All Awards = $12,264,714

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Center for Molecular Imaging Technology & Translation (CMITT)

Award Number: P41EB022544

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2017

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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