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NCBIB Center of BioModular Multiscale Systems (CBM2) for Precision Medicine

Award Number: P41EB020594
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/16/2015
PERIOD OF PERFORMANCE END DATE: 03/31/2031

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NCBIB Center of BioModular Multiscale Systems (CBM2) for Precision Medicine - TITLE: NCBIB Center of BioModular Multiscale Systems (CBM2) for Precision Medicine Abstract/Summary Liquid biopsies represent an exciting contribution to in vitro diagnostics (IVDs) because of the minimally invasive nature of securing these markers, the plethora of marker types, and the diverse molecular information they carry. Unfortunately, many of these markers have not been fully utilized in the clinic because disease-associated liquid biopsy markers are a vast minority in a mixed population making them difficult to molecularly analyze due to mass limits they impose on downstream processing. For example, a single extracellular vesicle can carry ~15,000 protein molecules and considering the high number of different protein types, ~0.06 molecules of a particular protein type are found in an EV. In the case of NGS for DNA/RNA analysis, high mass inputs are required as well demanding amplification of the input, which can mask important molecular features such as epigenetic modifications in DNA and the >170 different epitranscriptomic modifications in RNA. For cell free DNA, there can be ≤2 mutated molecules in 1 mL of plasma and as such, high levels of amplification are required. The NCBIB Center of BioModular Multiscale Systems (CBM2) for Precision Medicine is seeking to evolve its vision with the delivery of innovative technologies to process liquid biopsy biomarkers in a multi-omics format. The platform technologies possess the ability to isolate disease-associated biomarkers (outputs from Phase I) and analyze their molecular cargo using amplification-free assays with sufficient sensitivity to process single molecules (DNAs, RNAs, Phase II; proteins in Phase III; full complement of modifications in Phase III). This vision will be realized through a tightly focused, yet highly interactive Translational Research and Development (TR&D) efforts: (i) Solid-phase enzymatic nanoscale reactors coupled to nano-electrophoresis for detection and identification of single-molecules; (ii) label-free single-molecule detection using in-plane nanopores poised within a nanofluidic network to read the time-of-flight (ToF; related to apparent electrophoretic mobility of the target) and electronic signatures of single molecules for efficient identification fortified with machine learning (ML); and (iii) mixed-scale (nm → mm) and modular fluidic systems comprised of task-specific modules that can perform single-molecule processing of an entity secured from a liquid biopsy marker in an amplification-free format with full process automation. Delivery of CBM2’s platform technologies to the biomedical community will be realized through a production pipeline operated by the Center to produce mixed-scale structures in plastics. CBM2 consists of a highly accomplished and multidisciplinary team well versed in producing successful outcomes from large multi-institutional projects. The Center research will be facilitated by the extensive infrastructure in place resulting from its past and existing operations (2015 – 2025). Translation of CBM2 platform technologies into the biomedical community will be facilitated by an engaging technology training/dissemination program and an aggressive Collaborative and Service Project portfolio. Training on the Center’s new platform technologies will be facilitated through websites, in-person workshops, webinars, and CBM2 members’ extensive networks.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,215,649 )
2026	2026	UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	12	6/19/2026	COMPETING CONTINUATION	$1,215,649
2026	2025	UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	11	4/8/2026	NON-COMPETING CONTINUATION	$0
2026	2025	UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	11	6/17/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,215,649

Issue Date FY: 2025 ( Subtotal = $1,194,192 )
2025	2025	UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	11	7/29/2025	NON-COMPETING CONTINUATION	$1,194,192
2025	2025	UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	11	9/11/2025	NON-COMPETING CONTINUATION	$0
2025	2024	UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	10	10/24/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,194,192

Issue Date FY: 2024 ( Subtotal = $1,204,659 )
2024	2024	UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	10	7/18/2024	NON-COMPETING CONTINUATION	$1,204,659
														Subtotal = $1,204,659

Issue Date FY: 2023 ( Subtotal = $1,189,748 )
2023	2023	UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	9	8/21/2023	NON-COMPETING CONTINUATION	$1,189,748
														Subtotal = $1,189,748

Issue Date FY: 2022 ( Subtotal = $1,212,402 )
2022	2022	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	004	8	8/30/2022	NON-COMPETING CONTINUATION	$1,206,289
2022	2021	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	7	10/11/2021	COMPETING CONTINUATION	$6,113
2022	2021	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	7	12/6/2021	COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	7	11/13/2021	COMPETING CONTINUATION	$71,194
2022	2019	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	6	11/13/2021	NON-COMPETING CONTINUATION	-$71,194
														Subtotal = $1,212,402

Issue Date FY: 2021 ( Subtotal = $1,132,431 )
2021	2021	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	7	9/23/2021	COMPETING CONTINUATION	$1,132,431
														Subtotal = $1,132,431

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	6	7/30/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $1,207,661 )
2019	2019	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	6	6/10/2019	NON-COMPETING CONTINUATION	$1,207,661
														Subtotal = $1,207,661

Issue Date FY: 2018 ( Subtotal = $1,210,844 )
2018	2018	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	6/28/2018	NON-COMPETING CONTINUATION	$1,210,844
														Subtotal = $1,210,844

Issue Date FY: 2017 ( Subtotal = $1,210,887 )
2017	2017	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	004	4	7/3/2017	NON-COMPETING CONTINUATION	$1,209,662
2017	2016	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	3	4/26/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$546,957
2017	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	2/11/2017	NON-COMPETING CONTINUATION	-$1,248,537
2017	2016	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	2/11/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,249,762
2017	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	1	4/26/2017	NEW	-$546,957
														Subtotal = $1,210,887

Issue Date FY: 2016 ( Subtotal = $1,248,537 )
2016	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	7/18/2016	NON-COMPETING CONTINUATION	$1,248,537
														Subtotal = $1,248,537

Issue Date FY: 2015 ( Subtotal = $1,274,442 )
2015	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/16/2015	NEW	$1,274,442
														Subtotal = $1,274,442

Grand Total All Awards = $13,301,452

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NCBIB Center of BioModular Multiscale Systems (CBM2) for Precision Medicine

Award Number: P41EB020594

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/16/2015

PERIOD OF PERFORMANCE END DATE: 03/31/2031

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