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Biotechnology Resource Center of BioModular Multi-scale Systems (CBM2) for Precision Medicine

Award Number: P41EB020594
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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TITLE: Biotechnology Resource Center of BioModular Multi-scale Systems (CBM2) for Precision Medicine Overall: Developing New Technologies for Enabling Precision Medicine Abstract/Summary Liquid biopsies represent an exciting contribution to in vitro diagnostics (IVDs) because of the minimally invasive nature of securing markers, the plethora of marker types (circulating biological cells, cell-free molecules [proteins, micro-RNA, cell-free DNA], and extracellular vesicles [exosomes]), and the diverse molecular information they carry. Unfortunately, many of these markers have not been fully utilized in the clinic primarily because disease- associated liquid biopsy markers can be a vast minority in a mixed population making them difficult to find and analyze. This is partly due to a lack of platforms for their efficient isolation and tools to analyze the limited numbers of diseased molecules contained in a liquid biopsy isolate. For example, a single circulating tumor cell (CTC) carriers ~6 pg of genomic DNA. Next Generate Sequencing (NGS) requires ~30 ng of input nucleic acid material. Thus, high levels of amplification must be used to analyze a single CTC, which can create biased representation of the genome and/or mask important molecular features, such as epigenetic modifications. The Biotechnology Resource Center of BioModular Multi-scale Systems (CBM2) for Precision Medicine is seeking to evolve its vision with the delivery of new and innovative platform technologies to process liquid biopsy markers. The platform technologies will possess the ability to isolate disease-associated liquid biopsy markers (outputs from the active P41 Center) and analyze their molecular cargo using amplification-free assays with sufficient sensitivity to process single molecules (new to this application). This will be realized through three tightly focused, yet highly interactive Translational Research and Development efforts: (1) Solid-phase enzymatic nanoscale reactors and nano-electrophoresis for detection and identification of single-molecules; (2) label-free detection strategies using dual-nanopore time-of-flight (TOF) sensor poised within a fluidic network to read the TOF of single molecules for highly efficient identification; and (3) mixed-scale (nm ¿ mm) and modular fluidic systems comprised of task-specific modules assembled using robust strategies. The modular system can perform single-molecule processing of a molecular entity secured from a liquid biopsy marker in an amplification- free format with full process automation. Delivery of CBM2's platform technologies to the biomedical community will be realized through a production pipeline of chips operated by the Center. CBM2 consists of a highly accomplished and multidisciplinary team that is well versed in producing successful outcomes from large multi-institutional projects. The Center research will be facilitated by the extensive infrastructure in place as a result of the Center's current phase of operation (2015 – 2020). Translation of its platform technologies into the biomedical community will be facilitated by an engaging training/dissemination program, and an aggressive Collaborative and Service Project portfolio. Training on the Center's new platform technologies will be facilitated through workshops and CBM2 members' extensive research and clinical networks. Dissemination of new discoveries will be facilitated through a robust website, visiting scholars, meeting participation, and timely publications as well as the involvement of commercial entities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $1,189,748 )
2023	2023	UNIVERSITY OF KANSAS CENTER FOR RESEARCH INC	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	9	8/21/2023	NON-COMPETING CONTINUATION	$1,189,748
														Subtotal = $1,189,748

Issue Date FY: 2022 ( Subtotal = $1,212,402 )
2022	2022	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	004	8	8/30/2022	NON-COMPETING CONTINUATION	$1,206,289
2022	2021	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	7	12/6/2021	COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	7	11/13/2021	COMPETING CONTINUATION	$71,194
2022	2021	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	7	10/11/2021	COMPETING CONTINUATION	$6,113
2022	2019	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	6	11/13/2021	NON-COMPETING CONTINUATION	-$71,194
														Subtotal = $1,212,402

Issue Date FY: 2021 ( Subtotal = $1,132,431 )
2021	2021	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	7	9/23/2021	COMPETING CONTINUATION	$1,132,431
														Subtotal = $1,132,431

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	6	7/30/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $1,207,661 )
2019	2019	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	6	6/10/2019	NON-COMPETING CONTINUATION	$1,207,661
														Subtotal = $1,207,661

Issue Date FY: 2018 ( Subtotal = $1,210,844 )
2018	2018	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	6/28/2018	NON-COMPETING CONTINUATION	$1,210,844
														Subtotal = $1,210,844

Issue Date FY: 2017 ( Subtotal = $1,210,887 )
2017	2017	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	004	4	7/3/2017	NON-COMPETING CONTINUATION	$1,209,662
2017	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	2/11/2017	NON-COMPETING CONTINUATION	-$1,248,537
2017	2016	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	3	4/26/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$546,957
2017	2016	UNIVERSITY OF KANSAS CENTER FOR RESEARCH, INC.	2385 IRVING HILL RD	LAWRENCE	KS	66045	DOUGLAS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	3	2/11/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,249,762
2017	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	1	4/26/2017	NEW	-$546,957
														Subtotal = $1,210,887

Issue Date FY: 2016 ( Subtotal = $1,248,537 )
2016	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	7/18/2016	NON-COMPETING CONTINUATION	$1,248,537
														Subtotal = $1,248,537

Issue Date FY: 2015 ( Subtotal = $1,274,442 )
2015	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/16/2015	NEW	$1,274,442
														Subtotal = $1,274,442

Grand Total All Awards = $9,686,952

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Biotechnology Resource Center of BioModular Multi-scale Systems (CBM2) for Precision Medicine

Award Number: P41EB020594

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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