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Laboratory of Neuro Imaging Resource (LONIR)

Award Number: P41EB015922
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/1998
PERIOD OF PERFORMANCE END DATE: 02/29/2024

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Laboratory of Neuro Imaging Resource (LONIR) - PROJECT SUMMARY - OVERALL The LONIR is focused on developing innovative solutions for the investigation of imaging, genetics, behavioral and clinical data. The LONIR structure is designed to facilitate studies of dynamically changing anatomic frameworks, e.g., developmental, neurodegenerative, traumatic, and metastatic, by providing methods for the comprehensive understanding of the nature and extent of these processes. Specifically, TR&D1 (Data Science) focuses on methodological developments for the management and informatics of brain and related data. This project will develop and issue new methods for robust scientific data management to create an environment where scientific analyses can be reproduced and/or enhanced, data can be easily discovered and reused, and analysis results can be visualized and made publicly searchable. TR&D2 (Diffusion MRI and Connectomics) seeks to advance the study of brain connectivity using diffusion imaging and its powerful extensions. This project will go beyond traditional tensor models of diffusion for assessing tissue and fiber microstructure and connectivity, develop tract-based statistical analysis tools using Deep Learning, introduce novel adaptive connectivity mapping approaches, using L1 fusion of multiple tractography methods, and provide mechanisms to study connectivity and diffusion imaging over 10,000 subjects. (This technology and these methods will be managed and executed by the TR&D1 framework to distributed datasets totaling over 10,000 subjects). Lastly, our TR&D3 (Intrinsic Surface Mapping) develops a general framework for surface mapping in the high dimensional Laplace-Beltrami embedding space via the mathematical optimization of their Riemannian metric. Our approach here overcomes fundamental limitations in existing methods based on spherical registration by eliminating the metric distortion during the parameterization step, thus achieving much improved accuracy in mapping brain anatomy. Coupled with a mature and efficient administrative structure and comprehensive training and dissemination, this program serves a wide and important need in the scientific community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$784 )
2024	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90033	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	25	8/26/2024	NON-COMPETING CONTINUATION	-$784
														Subtotal = -$784

Issue Date FY: 2022 ( Subtotal = $1,217,435 )
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	25	5/27/2022	NON-COMPETING CONTINUATION	$1,217,435
2022	2022	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	25	6/29/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,217,435

Issue Date FY: 2021 ( Subtotal = $1,601,177 )
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	24	6/11/2021	NON-COMPETING CONTINUATION	$1,193,086
2021	2021	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	24	6/14/2021	SUPPLEMENT FOR EXPANSION	$408,091
														Subtotal = $1,601,177

Issue Date FY: 2020 ( Subtotal = $1,217,435 )
2020	2020	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	23	3/30/2020	NON-COMPETING CONTINUATION	$1,217,435
														Subtotal = $1,217,435

Issue Date FY: 2019 ( Subtotal = $1,217,435 )
2019	2019	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	22	4/26/2019	NON-COMPETING CONTINUATION	$1,217,435
														Subtotal = $1,217,435

Issue Date FY: 2018 ( Subtotal = $1,717,236 )
2018	2018	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	003	21	9/20/2018	COMPETING CONTINUATION	$480,063
2018	2018	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER STREET THIRD FLOOR	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	21	5/21/2018	COMPETING CONTINUATION	$1,717,236
2018	2017	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER STREET THIRD FLOOR	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	20	5/18/2018	NON-COMPETING CONTINUATION	$0
2018	2017	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER ST FL 3	LOS ANGELES	CA	90007	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	002	20	9/20/2018	NON-COMPETING CONTINUATION	-$480,063
														Subtotal = $1,717,236

Issue Date FY: 2017 ( Subtotal = $1,389,182 )
2017	2017	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER STREET THIRD FLOOR	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	20	6/1/2017	NON-COMPETING CONTINUATION	$138,919
2017	2017	UNIVERSITY OF SOUTHERN CALIFORNIA	3720 S FLOWER STREET THIRD FLOOR	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	20	4/6/2017	NON-COMPETING CONTINUATION	$1,250,263
														Subtotal = $1,389,182

Issue Date FY: 2016 ( Subtotal = $1,389,182 )
2016	2016	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	19	2/12/2016	NON-COMPETING CONTINUATION	$1,389,182
														Subtotal = $1,389,182

Issue Date FY: 2015 ( Subtotal = $1,359,263 )
2015	2015	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	18	2/17/2015	NON-COMPETING CONTINUATION	$1,359,263
														Subtotal = $1,359,263

Issue Date FY: 2014 ( Subtotal = -$10,584 )
2014	2013	UNIVERSITY OF SOUTHERN CALIFORNIA	3500 SOUTH FIGUEROA STREET 102	LOS ANGELES	CA	90089	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	17	5/8/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,187,436
2014	2013	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	16	5/8/2014	NON-COMPETING CONTINUATION	-$1,198,020
														Subtotal = -$10,584

Issue Date FY: 2013 ( Subtotal = $1,198,020 )
2013	2013	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	001	16	9/9/2013	NON-COMPETING CONTINUATION	$0
2013	2013	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	16	8/6/2013	NON-COMPETING CONTINUATION	$1,198,020
														Subtotal = $1,198,020

Issue Date FY: 2012 ( Subtotal = $1,781,980 )
2012	2012	UNIVERSITY OF CALIFORNIA-LOS ANGELES, BOARD OF REGENTS	11000 KINROSS AVENUE	LOS ANGELES	CA	90095	LOS ANGELES	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	15	7/28/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,781,980
														Subtotal = $1,781,980

Grand Total All Awards = $14,076,977

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Laboratory of Neuro Imaging Resource (LONIR)

Award Number: P41EB015922

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/1998

PERIOD OF PERFORMANCE END DATE: 02/29/2024

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