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Nonhuman Primate Antibody Resource for Immune Cell Depletion

Award Number: P40OD028116
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2020
PERIOD OF PERFORMANCE END DATE: 12/31/2029

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Nonhuman Primate Antibody Resource for Immune Cell Depletion - Project Summary – Overall Nonhuman primates (NHPs) have historically served as crucial animal models for diseases and for testing new therapies and vaccines that cannot be evaluated in small animal models. The utility of NHP models in research has been enhanced considerably by the use of immune cell-depleting antibodies that can target and lyse specific cell subsets in vivo. In models of infectious disease and vaccine testing, targeted immune cell depletion has been used to understand the pathogenesis of these infections and to design better vaccines to prevent them. Furthermore, immune cell depletion can be an effective immune-modulating therapy and the preclinical testing of these cell-depleting antibody drugs is often conducted in NHPs. Our P40-funded Center, “Nonhuman Primate Antibody Resource for Immune Cell Depletion,” has been a major source of immune cell-depleting antibodies for the scientific community, and our vital reagents have enabled NHP studies in fundamental, biomedical, and preclinical research. For the past 24 years, NIH has supported the Nonhuman Primate Reagent Resource’s efforts to develop, characterize, manufacture, and distribute immune cell-depleting antibodies for use in NHP models through an R24, which was then superseded by this and a P40 grant. The need for this program has been confirmed by the growth in program activity since its inception. Over the past 5-year cycle (2018-2022), this grant fulfilled 547 reagent requests to 139 investigators from 95 institutions. These reagents were cited in 73 publications and supported 226 NIH grants or programs. Nearly 1.16 kilograms of 14 distinct antibody reagents were distributed. In this P40 renewal, we propose to continue to support the scientific community by maintaining the large-scale manufacture and quality control of immune cell-depleting and control antibodies for use in NHPs. We will also develop and optimize antibodies against new high-priority NHP targets identified by the scientific community, via our outreach strategy and development request web portal tools. The reagent development will be prioritized by our External Advisory Board. Our established, secure web-based infrastructure will continue to be used for advertising reagents, receiving and fulfilling requests, and measuring program effectiveness through surveys and an interactive dashboard. In the proposed funding cycle, we will institute a new Curation and Informatics Component that will be dedicated to curating, tracking, distributing, and promoting the Center’s reagents. The Curation and Informatics Component will also be responsible for maintaining and upgrading the web portal to increase our alignment with FAIR and TRUST guidelines. Our vision is that our Center will not only generate invaluable reagents but will also enhance rigor and transparency in the use of our reagents to improve reproducibility. Finally, we will conduct applied research to develop a new antibody ‘primatization’ method to improve the performance of our depletion therapies in NHP studies. This award funds unique NHP cell-depleting antibodies that are indispensable tools to hundreds of NIH grants.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $496,815 )
2025	2025	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Research Infrastructure Programs	000	6	1/13/2025	COMPETING CONTINUATION	$496,815
2025	2025	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Research Infrastructure Programs	002	6	5/2/2025	COMPETING CONTINUATION	$209,355
2025	2024	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Research Infrastructure Programs	001	5	5/2/2025	NON-COMPETING CONTINUATION	-$209,355
														Subtotal = $496,815

Issue Date FY: 2024 ( Subtotal = $621,016 )
2024	2024	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Research Infrastructure Programs	001	5	5/14/2024	NON-COMPETING CONTINUATION	$124,203
2024	2024	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Research Infrastructure Programs	000	5	1/9/2024	NON-COMPETING CONTINUATION	$496,813
2024	2023	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Research Infrastructure Programs	002	4	5/20/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $621,016

Issue Date FY: 2023 ( Subtotal = $621,016 )
2023	2023	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Research Infrastructure Programs	002	4	2/22/2023	NON-COMPETING CONTINUATION	$62,102
2023	2023	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Research Infrastructure Programs	001	4	12/14/2022	NON-COMPETING CONTINUATION	$558,914
2023	2020	UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL	55 LAKE AVE N	WORCESTER	MA	01655	WORCESTER	USA	Research Infrastructure Programs	000	1	11/17/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $621,016

Issue Date FY: 2022 ( Subtotal = $621,016 )
2022	2022	UNIVERSITY OF MASSACHUSETTS	55 LAKE AVE NORTH	WORCESTER	MA	01655	WORCESTER	USA	Research Infrastructure Programs	001	3	5/5/2022	NON-COMPETING CONTINUATION	$62,102
2022	2022	UNIVERSITY OF MASSACHUSETTS	55 LAKE AVE NORTH	WORCESTER	MA	01655	WORCESTER	USA	Research Infrastructure Programs	000	3	12/11/2021	NON-COMPETING CONTINUATION	$558,914
														Subtotal = $621,016

Issue Date FY: 2021 ( Subtotal = $621,016 )
2021	2021	UNIVERSITY OF MASSACHUSETTS	55 LAKE AVE NORTH	WORCESTER	MA	01655	WORCESTER	USA	Research Infrastructure Programs	001	2	3/15/2021	NON-COMPETING CONTINUATION	$62,103
2021	2021	UNIVERSITY OF MASSACHUSETTS	55 LAKE AVE NORTH	WORCESTER	MA	01655	WORCESTER	USA	Research Infrastructure Programs	000	2	12/19/2020	NON-COMPETING CONTINUATION	$558,913
														Subtotal = $621,016

Issue Date FY: 2020 ( Subtotal = $944,587 )
2020	2020	UNIVERSITY OF MASSACHUSETTS	55 LAKE AVE NORTH	WORCESTER	MA	01655	WORCESTER	USA	Research Infrastructure Programs	002	1	7/28/2020	SUPPLEMENT FOR EXPANSION	$323,571
2020	2020	UNIVERSITY OF MASSACHUSETTS	55 LAKE AVE NORTH	WORCESTER	MA	01655	WORCESTER	USA	Research Infrastructure Programs	001	1	4/6/2020	NEW	$54,239
2020	2020	UNIVERSITY OF MASSACHUSETTS	55 LAKE AVE NORTH	WORCESTER	MA	01655	WORCESTER	USA	Research Infrastructure Programs	000	1	12/26/2019	NEW	$566,777
														Subtotal = $944,587

Grand Total All Awards = $3,925,466

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Nonhuman Primate Antibody Resource for Immune Cell Depletion

Award Number: P40OD028116

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2020

PERIOD OF PERFORMANCE END DATE: 12/31/2029

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