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Specific Pathogen Free 18 Baboon Research Resource (SPF18BRR)

Award Number: P40OD024628
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2017
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Specific Pathogen Free 18 Baboon Research Resource (SPF18BRR) - PROJECT SUMMARY: OVERALL COMPONENT This application is a competing renewal of the “Specific Pathogen Free 18 Baboon Research Resource” (SPF18BRR) P40 OD024628. The SPF18BRR was founded with NIH support at the University of Oklahoma Health Sciences Center (OUHSC) in 2002 and was relocated to the Keeling Center in 2017. The SPF18BRR has received continuous NIH support since it was founded. The SPF18BRR is the only national research resource of adventitious virus free olive baboons (Papio anubis) that are available to NIH grantees; intramural research programs of federal agencies, including the FDA, NSF and NIH; and other sponsors of biomedical research (private foundations, pharmaceutical companies, and contract research organizations). Absolutely unique in the entire world, the baboons in the SPF18BRR have an extensive bioexclusion list of 18 pathogens normally found in other wild and captive nonhuman primate colonies. The SPF18BRR has integrated multiple disciplines into a program designed to meet the needs of investigators who utilize its resources. During the proposed period of support, the SPF18BRR will continue to improve the resources it provides to users and will continue to add new information about the biology and research value of virus free baboons to its website. Baboons continue to be important animal model for genetically engineered pig xenotransplantation, are the only NHP model of respiratory syncytial virus and whooping cough, and they remain a very important model of bacterial sepsis. Additionally, baboons are excellent models of human COVID associated pneumonia, and they were instrumental in the development of approved vaccines for SARS CoV-2. Over the next five years, the SPF18BRR will focus on expanding the SPF18 baboon breeding colony to meet current and future biomedical research needs. The aims of the Resource Core Component address our continued commitment to expanding the SPF18 baboon breeding colony, we will increase the genetic diversity of the SPF18 breeding colony, and we will provide SPF18 baboons, facilities, training, and expertise to the scientific community. The Applied Research Component will include projects to develop methods to train and collect data from automated cognitive testing systems in socially living baboons; we will also determine a DNA methylation clock for our baboon colony, and will perform baseline biomarker analysis for a panel of 30 biomarkers for all animals over 3 years old in our colony; and, we will perform whole genome sequencing on 9 future conventional baboon breeders from the Southwest National Primate Center’s olive baboon colony, as well as targeted genomic sequencing on other interesting animals from the SPF18BRR. The overall goals of theSPF18BRR are to provide a national research resource of virus free olive baboons; provide baboon derived biological materials; provide education and training opportunities to scientist, colony managers, and animal caregivers who want to work with baboons; and to provide investigators with facilities and expertise to conduct studies using virus free baboons.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,274,599 )
2025	2025	THE UNIVERISTY OF TEXAS M.D. ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Research Infrastructure Programs	001	8	6/2/2025	NON-COMPETING CONTINUATION	$1,274,599
2025	2024	THE UNIVERISTY OF TEXAS M.D. ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Research Infrastructure Programs	000	7	1/21/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,274,599

Issue Date FY: 2024 ( Subtotal = $1,274,599 )
2024	2024	THE UNIVERISTY OF TEXAS MD ANDERSON CANCER CENTER, A COMPONENT OF THE UNIVERISTY OF TEXAS SYSTEM	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Research Infrastructure Programs	002	7	5/23/2024	NON-COMPETING CONTINUATION	$1,274,599
2024	2023	THE UNIVERISTY OF TEXAS MD ANDERSON CANCER CENTER, A COMPONENT OF THE UNIVERISTY OF TEXAS SYSTEM	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Research Infrastructure Programs	001	6	2/13/2024	COMPETING CONTINUATION	$13,351
2024	2022	THE UNIVERISTY OF TEXAS MD ANDERSON CANCER CENTER, A COMPONENT OF THE UNIVERISTY OF TEXAS SYSTEM	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Research Infrastructure Programs	000	5	2/13/2024	SUPPLEMENT FOR EXPANSION	-$13,351
														Subtotal = $1,274,599

Issue Date FY: 2023 ( Subtotal = $1,544,649 )
2023	2023	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Research Infrastructure Programs	001	6	8/25/2023	SUPPLEMENT FOR EXPANSION	$270,050
2023	2023	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Research Infrastructure Programs	000	6	3/17/2023	COMPETING CONTINUATION	$1,274,599
														Subtotal = $1,544,649

Issue Date FY: 2022 ( Subtotal = $900,000 )
2022	2022	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Research Infrastructure Programs	001	5	6/15/2022	SUPPLEMENT FOR EXPANSION	$900,000
2022	2021	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	000	5	1/27/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $900,000

Issue Date FY: 2021 ( Subtotal = $2,252,288 )
2021	2021	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Research Infrastructure Programs	004	5	7/28/2021	SUPPLEMENT FOR EXPANSION	$130,915
2021	2021	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	002	5	7/13/2021	NON-COMPETING CONTINUATION	$0
2021	2021	UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER, THE	1515 HOLCOMBE BLVD	HOUSTON	TX	77030	HARRIS	USA	Research Infrastructure Programs	003	5	7/19/2021	SUPPLEMENT FOR EXPANSION	$499,948
2021	2021	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Research Infrastructure Programs	001	5	5/21/2021	SUPPLEMENT FOR EXPANSION	$402,499
2021	2021	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	000	5	5/18/2021	NON-COMPETING CONTINUATION	$1,218,926
														Subtotal = $2,252,288

Issue Date FY: 2020 ( Subtotal = $1,608,569 )
2020	2020	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Research Infrastructure Programs	002	4	6/6/2020	SUPPLEMENT FOR EXPANSION	$382,993
2020	2020	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	001	4	5/20/2020	NON-COMPETING CONTINUATION	$1,225,576
2020	2019	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	000	3	12/17/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,608,569

Issue Date FY: 2019 ( Subtotal = $1,223,854 )
2019	2019	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	001	3	5/30/2019	NON-COMPETING CONTINUATION	$1,223,854
2019	2018	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	000	2	12/7/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,223,854

Issue Date FY: 2018 ( Subtotal = $1,509,101 )
2018	2018	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Research Infrastructure Programs	002	2	9/13/2018	SUPPLEMENT FOR EXPANSION	$359,000
2018	2018	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	001	2	6/7/2018	NON-COMPETING CONTINUATION	$115,011
2018	2018	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	000	2	6/2/2018	NON-COMPETING CONTINUATION	$1,035,090
														Subtotal = $1,509,101

Issue Date FY: 2017 ( Subtotal = $946,402 )
2017	2017	UNIVERSITY OF TEXAS M D ANDERSON CANCER CENTER	1515 HOLCOMBE BLVD UNIT 207	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	000	1	8/15/2017	NEW	$946,402
														Subtotal = $946,402

Grand Total All Awards = $12,534,061

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Specific Pathogen Free 18 Baboon Research Resource (SPF18BRR)

Award Number: P40OD024628

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2017

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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