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National Gnotobiotic Resource Center

Award Number: P40OD010995
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2003
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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National Gnotobiotic Resource Center - Environmental factors modify genetic susceptibility to many chronic diseases. Resident microbiota profoundly influence physiologic responses in multiple organs and are linked to many inflammatory (IBD, NASH, atherosclerosis, MS), metabolic (obesity, diabetes, metabolic syndrome, osteoporosis, hypertension), neoplastic (colon, pancreatic cancer) and behavioral (depression, autism) disorders, and responses to treatments (immunotherapies, biologic therapies). Altered microbiota (dysbiosis) and metabolites associated with these conditions and the Human Microbiome Project make this research a worldwide priority. However, functional consequences and the primary vs. secondary nature of these compositional changes and the role of individual bacterial species and combinations are poorly understood. Gnotobiotic animal models address causality and mechanisms of these host-microbe interactions. The National Gnotobiotic Rodent Resource Center (NGRRC) provides an essential resource for local and national multidisciplinary investigators to explore these key functional relationships. The NGRRC provides germ-free (GF, sterile) wild type and genetically- engineered gnotobiotic mice that are not available to most investigators due to the specialized technical expertise and stringent husbandry necessary for their creation, breeding and study beyond the resources and expertise of most NIH grantees. Our resource allows investigators to examine physiologic and pathogenic differences in GF and gnotobiotic (selectively colonized) vs. conventionally raised mice, functional relevance of bacterial genes and individual and defined groups of microbes to explore host/microbe, microbe/microbe and dietary/microbe interactions. Maintaining gnotobiotic animals is extremely labor intensive, expensive and requires considerable training to maintain sterility. Goal: Support broadly based gnotobiotic research by local and national NIH-funded investigators with reliable, cost-effective and easily accessed resources. Aims: 1. Provide GF and gnotobiotic WT and mutant mice, their tissues and cells to NIH-funded investigators. 2. Derive additional GF genetically engineered mouse strains. 3. Support pilot studies for new investigators to generate preliminary data for NIH grant applications. 4. Train personnel to develop murine gnotobiotic facilities in other institutions. 5. Optimize fecal transfer techniques, using pooled complex human fecal microbial communities from healthy donors and patients with several high profile Western diseases and validate in vivo outcomes to create protocols and a repository to achieve highly reproducible results for our users in their gnotobiotic studies. (Research Component). We provide a unique, cost effective and essential resource for a large, multidisciplinary group of NIH-funded investigators to study physiologic and pathophysiologic functions of normal and dysbiotic resident microbiota, alone or in aggregate, with particular emphasis on gene/ environmental interactions in genetically altered mice (transgenic, knockout or spontaneously mutated) with altered physiology and disease phenotypes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $776,328 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	002	22	7/17/2025	NON-COMPETING CONTINUATION	$776,328
2025	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	001	21	3/4/2025	COMPETING CONTINUATION	$14,178
2025	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	20	3/4/2025	NON-COMPETING CONTINUATION	-$14,178
														Subtotal = $776,328

Issue Date FY: 2024 ( Subtotal = $776,328 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	21	7/9/2024	COMPETING CONTINUATION	$776,328
														Subtotal = $776,328

Issue Date FY: 2023 ( Subtotal = $529,149 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	20	6/8/2023	NON-COMPETING CONTINUATION	$529,149
														Subtotal = $529,149

Issue Date FY: 2022 ( Subtotal = $541,747 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	19	6/28/2022	NON-COMPETING CONTINUATION	$541,747
														Subtotal = $541,747

Issue Date FY: 2021 ( Subtotal = $783,629 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	001	18	6/16/2021	NON-COMPETING CONTINUATION	$556,091
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	002	18	7/1/2021	SUPPLEMENT FOR EXPANSION	$227,538
2021	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	17	2/4/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $783,629

Issue Date FY: 2020 ( Subtotal = $574,104 )
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	002	17	7/1/2020	NON-COMPETING CONTINUATION	$574,104
2020	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	001	16	2/6/2020	COMPETING CONTINUATION	$47,731
2020	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	15	2/6/2020	SUPPLEMENT FOR EXPANSION	-$47,731
														Subtotal = $574,104

Issue Date FY: 2019 ( Subtotal = $587,706 )
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	002	16	8/1/2019	COMPETING CONTINUATION	$0
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	001	16	7/15/2019	COMPETING CONTINUATION	$587,706
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	003	16	8/3/2019	COMPETING CONTINUATION	$0
2019	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	15	7/14/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $587,706

Issue Date FY: 2018 ( Subtotal = $773,712 )
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	15	6/7/2018	NON-COMPETING CONTINUATION	$576,182
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	001	15	8/2/2018	SUPPLEMENT FOR EXPANSION	$197,530
														Subtotal = $773,712

Issue Date FY: 2017 ( Subtotal = $547,373 )
2017	2017	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	14	6/21/2017	NON-COMPETING CONTINUATION	$518,565
2017	2017	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	001	14	8/10/2017	NON-COMPETING CONTINUATION	$28,808
														Subtotal = $547,373

Issue Date FY: 2016 ( Subtotal = $576,182 )
2016	2016	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	13	6/20/2016	NON-COMPETING CONTINUATION	$576,182
														Subtotal = $576,182

Issue Date FY: 2015 ( Subtotal = $564,658 )
2015	2015	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	12	6/30/2015	NON-COMPETING CONTINUATION	$564,658
														Subtotal = $564,658

Issue Date FY: 2014 ( Subtotal = $576,182 )
2014	2014	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	002	11	9/15/2014	COMPETING CONTINUATION	$576,182
2014	2013	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	001	10	9/10/2014	NON-COMPETING CONTINUATION	$0
2014	2013	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	10	6/11/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $576,182

Issue Date FY: 2013 ( Subtotal = $510,018 )
2013	2013	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	10	6/10/2013	NON-COMPETING CONTINUATION	$510,018
														Subtotal = $510,018

Issue Date FY: 2012 ( Subtotal = $1 )
2012	2012	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	440 WEST FRANKLIN ST, CB #1350	CHAPEL HILL	NC	27599	ORANGE	USA	Research Infrastructure Programs	000	9	5/25/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1
														Subtotal = $1

Grand Total All Awards = $8,117,117

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National Gnotobiotic Resource Center

Award Number: P40OD010995

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2003

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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