Monday, September 16, 2024 9/16/2024

Referral Ctr-Animal models of human genetic disease

Award Number: P40OD010939
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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! PROJECT SUMMARY/ABSTRACT The overall objective of this project is for the Referral Center for Animal Models of Human Genetic Disease (RCAM) to continue to serve as a national referral and resource center to discover, characterize, and maintain colonies of large animals with hereditary diseases homologous to those found in human patients that can be used to translate preclinical trials from kennel to clinic. The naturally occurring animal models to be sought, and those currently available, represent true orthologs of their respective human disease, involving defects in the same genes and resulting in the same molecular, biochemical, pathological, and clinical signs as in human patients. While numerous naturally occurring models of disease have been identified and proven critical for preclinical trials, the rate at which new mutations are found and characterized is limited. Therefore, we will now also create feline models that bear the same genetic mutation as those found in human diseases using CRISPR/Cas9 genome editing. These animal models can be generated quickly, will be completely orthologous to the human system, and will be maintained in breeding colonies and disseminated to other investigators. Both newly discovered and generated models are invaluable for the study of disease pathogenesis and the evaluation of the safety and efficacy of therapies prior to clinical trials in human patients. Models offering new opportunities to investigate disease pathogenesis and approaches to therapy will be emphasized in consultation with an Advisory Committee. Verified models will be made available to other investigators at a nominal fee-for-service in the form of DNA, cells, frozen semen, and breeding stock. We will also serve as a resource for normal large animals and their tissues for other investigators, and we will continue to offer facilities where outside investigators can perform experiments in large animal models on a Program Income Fund, fee-for-service basis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	000	38	10/18/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $723,843 )
2023	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	001	38	3/6/2023	NON-COMPETING CONTINUATION	$72,383
2023	2023	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	000	38	12/28/2022	NON-COMPETING CONTINUATION	$651,460
														Subtotal = $723,843

Issue Date FY: 2022 ( Subtotal = $723,843 )
2022	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	000	37	1/12/2022	NON-COMPETING CONTINUATION	$651,459
2022	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	001	37	5/17/2022	NON-COMPETING CONTINUATION	$72,384
														Subtotal = $723,843

Issue Date FY: 2021 ( Subtotal = $723,843 )
2021	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	000	36	12/19/2020	NON-COMPETING CONTINUATION	$651,459
2021	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	002	36	7/7/2021	NON-COMPETING CONTINUATION	$0
2021	2021	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	001	36	3/15/2021	NON-COMPETING CONTINUATION	$72,384
														Subtotal = $723,843

Issue Date FY: 2020 ( Subtotal = $723,843 )
2020	2020	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	001	35	3/4/2020	NON-COMPETING CONTINUATION	$72,384
2020	2020	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	000	35	12/27/2019	NON-COMPETING CONTINUATION	$651,459
														Subtotal = $723,843

Issue Date FY: 2019 ( Subtotal = $723,843 )
2019	2019	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	002	34	5/21/2019	COMPETING CONTINUATION	$28,186
2019	2019	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	000	34	1/18/2019	COMPETING CONTINUATION	$723,843
2019	2017	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	001	33	5/21/2019	NON-COMPETING CONTINUATION	-$28,186
														Subtotal = $723,843

Issue Date FY: 2017 ( Subtotal = $709,650 )
2017	2017	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	003	33	8/10/2017	NON-COMPETING CONTINUATION	$70,965
2017	2017	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	000	33	12/9/2016	NON-COMPETING CONTINUATION	$638,685
2017	2016	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	002	32	3/31/2017	EXTENSION WITH OR WITHOUT FUNDS	$27,710
2017	2015	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	001	31	3/31/2017	NON-COMPETING CONTINUATION	-$27,710
														Subtotal = $709,650

Issue Date FY: 2016 ( Subtotal = $709,650 )
2016	2016	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	000	32	1/25/2016	EXTENSION WITH OR WITHOUT FUNDS	$638,685
2016	2016	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	001	32	3/7/2016	EXTENSION WITH OR WITHOUT FUNDS	$70,965
														Subtotal = $709,650

Issue Date FY: 2015 ( Subtotal = $695,456 )
2015	2015	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	000	31	1/30/2015	NON-COMPETING CONTINUATION	$695,456
														Subtotal = $695,456

Issue Date FY: 2014 ( Subtotal = $707,612 )
2014	2014	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	000	30	12/31/2013	NON-COMPETING CONTINUATION	$643,287
2014	2014	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	001	30	5/1/2014	NON-COMPETING CONTINUATION	$64,325
														Subtotal = $707,612

Issue Date FY: 2013 ( Subtotal = $719,538 )
2013	2013	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	000	29	1/17/2013	COMPETING CONTINUATION	$639,589
2013	2013	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	001	29	6/27/2013	COMPETING CONTINUATION	$79,949
														Subtotal = $719,538

Issue Date FY: 2012 ( Subtotal = $713,478 )
2012	2012	UNIVERSITY OF PENNSYLVANIA	3451 WALNUT STREET	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Research Infrastructure Programs	000	28	2/24/2012	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$713,478
														Subtotal = $713,478

Grand Total All Awards = $7,874,599

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Referral Ctr-Animal models of human genetic disease

Award Number: P40OD010939

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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