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The MDIBL Center for Comparative Biology of Tissue Repair, Regeneration and Aging

Award Number: P30GM154610
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/05/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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The MDIBL Center for Comparative Biology of Tissue Repair, Regeneration and Aging - OVERALL PROJECT SUMMARY Limited regeneration of damaged organs and tissues in humans leads to chronic disease and degeneration, while in many invertebrates and lower vertebrates, cellular regeneration repairs and preserves tissue function throughout the lifespan. COBRE Phases I and II Comparative Biology of Tissue Repair, Regeneration and Aging, played a central role in establishing the Kathryn W. Davis Center for Regenerative Biology and Aging (Davis Center) at the MDI Biological Laboratory (MDIBL) as a leading institute in Comparative Biology. The Davis Center was founded on the principle that comparative studies of diverse animal models would lead to a mechanistic understanding of tissue and organ regeneration and identify key points of intervention to improve regeneration in human tissues. In addition, Davis Center research has focused on mechanisms of aging using multiple organisms to learn how cellular anabolic and catabolic pathways may be linked to extension of healthspan. Comparative studies such as these provide a screening platform and rational foundation for development of regenerative medicine therapies, including small molecule drug candidates capable of stimulating tissue regeneration and slowing or reversing aging-induced degenerative changes in patients. COBRE Phases I and II supported eight early-career Project Leaders and one mid-career Project Leader. Six Project Leaders graduated with major independent grant support and the most recent COBRE recruit, Prayag Murawala, has achieved significant professional success and is on a path to independent R01 support. Past and current COBRE Project Leaders have achieved multiple professional milestones in publications, grants, patents, new disease models and research tools, and formation of an IDeA program/Maine state government partnership that allowed MDIBL to obtain $3M in voter-approved state bond funding to expand research infrastructure. COBRE Phase III will continue to build the research infrastructure of the Davis Center by establishing self- sustaining core facilities and funding pilot programs in Aging and Regeneration research. Essential core services will be provided to COBRE graduates, MDIBL investigators, visiting scientists, pilot project awardees, MDIBL course participants from INBRE network institutions, and investigators in Northeast region (NER) IDeA states. Pilot project funding and imaging technology access grants will be made available to all investigators in NER IDeA states. COBRE Phase III will greatly enhance the development of the Davis Center and MDIBL, which in turn will ensure the continued enhancement of the biomedical research environment in Maine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,265,252 )
2025	2025	THE MOUNT DESERT ISLAND BIOLOGICAL LABORATORY	159 OLD BAR HARBOR RD	BAR HARBOR	ME	04609	HANCOCK	USA	Biomedical Research and Research Training	000	2	8/27/2025	NON-COMPETING CONTINUATION	$1,265,252
														Subtotal = $1,265,252

Issue Date FY: 2024 ( Subtotal = $1,249,777 )
2024	2024	THE MOUNT DESERT ISLAND BIOLOGICAL LABORATORY	159 OLD BAR HARBOR RD	BAR HARBOR	ME	04609	HANCOCK	USA	Biomedical Research and Research Training	000	1	7/3/2024	NEW	$1,249,777
														Subtotal = $1,249,777

Grand Total All Awards = $2,515,029

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The MDIBL Center for Comparative Biology of Tissue Repair, Regeneration and Aging

Award Number: P30GM154610

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/05/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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