Wednesday, July 2, 2025 7/2/2025

Center for Cancer Biology Research

Award Number: P30GM145398
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2023
PERIOD OF PERFORMANCE END DATE: 02/29/2028

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Center for Cancer Biology Research - This CoBRE Phase III application aims to continue support for the Center for Cancer Biology Research (CCBR) which has established a strong research program within Sanford Research, Sioux Falls, SD. The original mission of the CCBR was to establish and grow cancer research with a focus on basic and translational activities. During Phase I CoBRE funding, the CCBR was established with five Project Leaders. Importantly, critical infrastructure, in the form of Scientific Cores, was developed and a Pilot Grant Program was initiated. The success of Phase I was marked by attainment of R01 level funding by Project Leaders who graduated from CoBRE funding and remain successful to this day. In addition, Project Leaders published important scientific papers in peer-reviewed journals and the Scientific Core functions began expanding as did their expertise. The power of the Pilot Grant program was demonstrated by scientific publications and obtaining of funding by awardees. These milestones enabled the awarding of CoBRE Phase II funding for the CCBR. While the missions of the CCBR remained unchanged, the influx of physician/scientists to the CCBR prompted an extensive focus on translational cancer research; a theme that remains strongly in place. Phase II Project Leaders were also successful in obtaining extramural funding and graduated from CoBRE support. Moreover, the Scientific Cores further expanded their services and began a more systematic approach (SmartSheets) to order, track and report back services to their users. In addition, fee-for-service schedules were developed for the Scientific Cores as they prepared for attaining self-sufficiency. The Pilot Grant program continued to provide funding to investigators who utilized these resources to successfully publish and obtain funding. Phase III CoBRE funding will enable the CCBR's Scientific Cores to reach a state of self-sustainability while continuing to offer critical services to CCBR members as well as non-CCBR members of Sanford Research and investigators from regional and national institutions. A critical component of this Phase III application will fund the CCBR's Pilot Grant Program. These Pilot Grants have proven to be essential sources of funding for new investigators and more seasoned faculty that want to test innovative hypotheses or require resources to generate data necessary to secure extramural funding. Historically, the CCBR's Pilot Grant Awardees have demonstrated that this funding results in peer-reviewed scientific publications and enables them to obtain funding from external sources. Moreover, a large percent of Pilot Grant projects utilizes the CCBR's Scientific Cores thereby contributing to their self-sustainability. The CCBR's successes over the past decade of CoBRE funding are a testament to the transformative power of this funding mechanism. Obtaining the final Phase of CoBRE funding will further strengthen the Scientific Cores, translational research, scientific culture of innovative science and the research infrastructure of the CCBR that began with Phase I CoBRE funding.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,120,500 )
2025	2025	SANFORD RESEARCH	801 BROADWAY N	FARGO	ND	58102	CASS	USA	Biomedical Research and Research Training	000	3	6/24/2025	NON-COMPETING CONTINUATION	$1,120,500
														Subtotal = $1,120,500

Issue Date FY: 2024 ( Subtotal = $1,245,000 )
2024	2024	SANFORD RESEARCH	801 BROADWAY N	FARGO	ND	58102	CASS	USA	Biomedical Research and Research Training	001	2	7/22/2024	NON-COMPETING CONTINUATION	$124,500
2024	2024	SANFORD RESEARCH	801 BROADWAY N	FARGO	ND	58102	CASS	USA	Biomedical Research and Research Training	000	2	2/27/2024	NON-COMPETING CONTINUATION	$1,120,500
2024	2024	SANFORD RESEARCH	801 BROADWAY N	FARGO	ND	58102	CASS	USA	Biomedical Research and Research Training	002	2	9/5/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,245,000

Issue Date FY: 2023 ( Subtotal = $1,245,000 )
2023	2023	SANFORD RESEARCH	2301 E 60TH ST N	SIOUX FALLS	SD	57104	MINNEHAHA	USA	Biomedical Research and Research Training	000	1	3/24/2023	NEW	$1,245,000
														Subtotal = $1,245,000

Grand Total All Awards = $3,610,500

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Center for Cancer Biology Research

Award Number: P30GM145398

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2023

PERIOD OF PERFORMANCE END DATE: 02/29/2028

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