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Biomolecular Structure and Dynamics

Award Number: P30GM140963
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/10/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Biomolecular Structure and Dynamics - The Center of Biomedical Research Excellence in Biomolecular Structure and Dynamics (CBSD COBRE) at the University of Montana (UM) supports research that applies the methods and concepts of biophysics, structural biology and chemistry to understand the mechanistic basis of biological processes in health and disease. The CBSD COBRE draws from a pool of about 60 faculty members from the basic and biomedical sciences in the College of Humanities and Sciences and the College of Health. This phase III proposal builds on the successes of phases I and II of COBRE support for the CBSD that have led to the hiring of seven new faculty and early career support for an additional nine UM faculty. The direct COBRE support for their research efforts, the COBRE-supported research cores that underpin their research programs and the vibrant seminar and mentoring programs sponsored by the CBSD COBRE have propelled these early career investigators to success. As a cohort, they have been awarded 39 grants that brought in $16.8 million to support their research and have generated 83 well-cited peer-reviewed publications. During phases I and II, the CBSD COBRE has supported four research cores, the Integrated Structural Biology Core (ISBC), which provides gene to structure services, the BioSpectroscopy Core Research Laboratory (BCRL), which gives CBSD researchers access to state-of-the-art fluorescence lifetime and imaging instrumentation, the Molecular Computation Core Facility (MCCF), which provides molecular docking, drug discovery and molecular dynamics (MD) platforms, and the Mass Spectrometry Core Facility (MSCF), which applies proteomic and metabolomic approaches to CBSD research problems. The growth in the number of CBSD researchers afforded by investment in early career investigators and strong investment in research core infrastructure during phases I and II of COBRE support, which has included more than $2 million in new equipment resulting from extramural equipment grants, has positioned the CBSD well to attain long-term sustainability with phase III COBRE support. The CBSD COBRE will use the phase III COBRE to pursue three specific aims designed to sustain the CBSD beyond phase III. With specific aim 1, we will continue to expand the cutting-edge capabilities of our research cores by carefully prioritizing COBRE and institutional resources so that the cores respond to the needs of their users and by continuing to vigorously pursue extramural funding for equipment that enhances core infrastructure. Specific aim 2 will evolve the role of the Administrative Core to lead the CSBD to sustainability through strategic financial planning and ongoing mentoring programs that keep CBSD researchers across career stages at the leading edge of their research areas. Finally, specific aim 3 will develop a Pilot Project program designed to incentivize new scientific directions that not only use, but also expand the technical capabilities of our research cores. This carefully-designed framework will ensure the long-term sustainability of the CBSD and the vital research community that it supports.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF MONTANA	32 CAMPUS DR	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	000	4	6/9/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,313,815 )
2024	2024	UNIVERSITY OF MONTANA	32 CAMPUS DR	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	001	4	8/5/2024	NON-COMPETING CONTINUATION	$1,108,200
2024	2024	UNIVERSITY OF MONTANA	32 CAMPUS DR	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	002	4	9/12/2024	SUPPLEMENT FOR EXPANSION	$205,615
2024	2023	UNIVERSITY OF MONTANA	32 CAMPUS DR	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	000	3	6/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,313,815

Issue Date FY: 2023 ( Subtotal = $1,352,079 )
2023	2023	UNIVERSITY OF MONTANA	32 CAMPUS DR	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	001	3	9/6/2023	NON-COMPETING CONTINUATION	$1,108,200
2023	2023	UNIVERSITY OF MONTANA	32 CAMPUS DR	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	002	3	9/11/2023	SUPPLEMENT FOR EXPANSION	$243,879
2023	2022	UNIVERSITY OF MONTANA	32 CAMPUS DR	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	000	2	4/10/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,352,079

Issue Date FY: 2022 ( Subtotal = $2,045,721 )
2022	2022	UNIVERSITY OF MONTANA	32 CAMPUS DR MAIN HALL	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	003	2	8/25/2022	SUPPLEMENT FOR EXPANSION	$670,730
2022	2022	UNIVERSITY OF MONTANA	32 CAMPUS DR MAIN HALL	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	002	2	8/18/2022	SUPPLEMENT FOR EXPANSION	$205,815
2022	2022	UNIVERSITY OF MONTANA	32 CAMPUS DR MAIN HALL	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	001	2	8/16/2022	NON-COMPETING CONTINUATION	$1,108,200
2022	2022	UNIVERSITY OF MONTANA	32 CAMPUS DR MAIN HALL	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	000	1	6/26/2022	SUPPLEMENT FOR EXPANSION	$60,976
														Subtotal = $2,045,721

Issue Date FY: 2021 ( Subtotal = $1,120,200 )
2021	2021	UNIVERSITY OF MONTANA	32 CAMPUS DR MAIN HALL	MISSOULA	MT	59812	MISSOULA	USA	Biomedical Research and Research Training	000	1	8/10/2021	NEW	$1,120,200
														Subtotal = $1,120,200

Grand Total All Awards = $5,831,815

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Biomolecular Structure and Dynamics

Award Number: P30GM140963

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/10/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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