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Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)

Award Number: P30ES017885
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2011
PERIOD OF PERFORMANCE END DATE: 03/31/2027

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Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) - This is a competing renewal application for the Environmental Health Sciences Core Center at the University of Michigan, submitted in the final year of our second term of support. Our Center is organized around the theme of critical windows of susceptibility to environmental exposures as important determinants of disease, forming the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD). Lifestage, as used in this application, refers to clinically-recognized stages of development, mid-life, and aging that pertain to the preconception, prenatal, infant, child, adolescent, reproductive age adult, and aging adult periods. Our Center builds on a strong foundation of research activity and support in environmental health sciences, with 22 NIEHS grants and projects, including Outstanding New Environmental Health Scientist (ONES) and Revolutionizing Innovative, Visionary Environmental health Research (RIVER) awards and participation in Superfund and other NIEHS programs. The M-LEEaD mission is to accelerate research that defines impacts of environmental exposures during vulnerable life stages and to promote translation of findings to improve clinical and public health interventions for the mitigation of disease. Our Center implements its mission through infrastructural support of established and new investigators applying novel transdisciplinary approaches that increase understanding of how exposures target vulnerable stages of life. Support for research is provided through integrated Center programs that include a Pilot Project Program, three Facility Cores, and three Research Teams to enhance translation of research findings into applications for patients and communities to support a comprehensive and integrated environmental health paradigm. Facility Cores are: Integrated Health Sciences (IHS); Exposure Assessment (EA); and Pan-Omics and Data Science (PODS). Research Teams are organized around translational impact. Research is coupled with engagement of stakeholder communities through the Community Engagement Core (CEC), and training of future leaders through our Career Development Program. An Administrative Core oversees the functioning of the Center. M-LEEaD strives to accomplish its mission through four specific aims: 1) Integrate institutional programs and facilities to provide structure and resources that accelerate understanding of complex relationships among environmental exposures, human biology, and disease; 2) Foster integration and cooperation among investigators across traditional and emerging disciplines to conduct research that translates to improved strategies to prevent environmentally-induced disorders; 3) Build programmatic and scientific capacity through support for scientists at critical career stages to engage in research that addresses critical questions in environmental health; and 4) Engage with affected communities via partnerships in a multidirectional manner to identify community environmental health concerns and collaboratively translate research findings into action to promote health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	000	13	12/12/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $1,409,717 )
2025	2025	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	001	13	6/14/2025	NON-COMPETING CONTINUATION	$1,409,717
2025	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	000	12	11/26/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,409,717

Issue Date FY: 2024 ( Subtotal = $1,635,753 )
2024	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	003	12	3/25/2024	SUPPLEMENT FOR EXPANSION	$164,424
2024	2024	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	002	12	3/21/2024	NON-COMPETING CONTINUATION	$1,471,329
2024	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	001	11	2/2/2024	NON-COMPETING CONTINUATION	$0
2024	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	000	11	12/12/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,635,753

Issue Date FY: 2023 ( Subtotal = $1,660,117 )
2023	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON STREET	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	002	11	3/25/2023	NON-COMPETING CONTINUATION	$1,510,380
2023	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON STREET	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	003	11	4/27/2023	SUPPLEMENT FOR EXPANSION	$149,737
2023	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	001	10	2/1/2023	COMPETING CONTINUATION	$193,192
2023	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE, SUITE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	000	9	2/1/2023	NON-COMPETING CONTINUATION	-$193,192
														Subtotal = $1,660,117

Issue Date FY: 2022 ( Subtotal = $1,548,502 )
2022	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	002	10	6/17/2022	COMPETING CONTINUATION	$1,548,502
2022	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	000	9	3/23/2022	NON-COMPETING CONTINUATION	$0
2022	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	001	9	6/7/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,548,502

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	001	9	7/7/2021	NON-COMPETING CONTINUATION	$0
2021	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	000	9	2/2/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $1,498,503 )
2020	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	003	9	3/27/2020	NON-COMPETING CONTINUATION	$1,498,503
2020	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	000	8	11/15/2019	NON-COMPETING CONTINUATION	$0
2020	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	001	8	12/17/2019	NON-COMPETING CONTINUATION	$0
2020	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	002	8	1/13/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,498,503

Issue Date FY: 2019 ( Subtotal = $1,655,519 )
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	002	8	4/1/2019	NON-COMPETING CONTINUATION	$1,617,549
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	001	7	1/23/2019	SUPPLEMENT FOR EXPANSION	$37,970
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	003	8	7/22/2019	NON-COMPETING CONTINUATION	$0
2019	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	000	7	10/29/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,655,519

Issue Date FY: 2018 ( Subtotal = $1,624,143 )
2018	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	002	7	9/6/2018	SUPPLEMENT FOR EXPANSION	$45,568
2018	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	000	7	3/23/2018	NON-COMPETING CONTINUATION	$1,500,595
2018	2018	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	001	7	9/5/2018	SUPPLEMENT FOR EXPANSION	$77,980
														Subtotal = $1,624,143

Issue Date FY: 2017 ( Subtotal = $1,545,231 )
2017	2017	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	000	6	4/5/2017	NON-COMPETING CONTINUATION	$1,501,541
2017	2017	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	001	6	9/18/2017	SUPPLEMENT FOR EXPANSION	$43,690
														Subtotal = $1,545,231

Issue Date FY: 2016 ( Subtotal = $1,579,876 )
2016	2016	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	000	5	6/22/2016	COMPETING CONTINUATION	$1,502,489
2016	2016	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	001	5	9/20/2016	SUPPLEMENT FOR EXPANSION	$77,387
														Subtotal = $1,579,876

Issue Date FY: 2014 ( Subtotal = $1,279,729 )
2014	2014	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	000	4	4/4/2014	NON-COMPETING CONTINUATION	$1,279,729
														Subtotal = $1,279,729

Issue Date FY: 2013 ( Subtotal = $1,149,195 )
2013	2013	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	001	3	7/12/2013	NON-COMPETING CONTINUATION	$93,813
2013	2013	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	000	3	4/10/2013	NON-COMPETING CONTINUATION	$1,055,382
														Subtotal = $1,149,195

Issue Date FY: 2012 ( Subtotal = $1,044,983 )
2012	2012	UNIVERSITY OF MICHIGAN	3003 S STATE ST 3089 WOLVERINE	ANN ARBOR	MI	48109	WASHTENAW	USA	Environmental Health	000	2	3/30/2012	NON-COMPETING CONTINUATION	$1,044,983
														Subtotal = $1,044,983

Issue Date FY: 2011 ( Subtotal = $931,500 ) (Continued on the next page)
Grand Total All Awards = $18,562,768

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Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)

Award Number: P30ES017885

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2011

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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