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Cedars-Sinai Digestive Diseases Research Center

Award Number: P30DK138899
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/17/2026
PERIOD OF PERFORMANCE END DATE: 05/31/2031

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Cedars-Sinai Digestive Diseases Research Center - OVERALL: PROJECT SUMMARY The Cedars-Sinai Digestive Diseases Research Center (CSDDRC) is designed to leverage the substantial and multidisciplinary research base and exceptional research facilities at Cedars-Sinai Medical Center (CSMC) to attract colleagues and junior scientists and to provide solutions to as-yet unsolved problems in digestive diseases research. The CSDDRC has 58 members and a total peer-reviewed direct cost of $26.1 million in the research base, of which $9.7 million (37.3%) is from the NIDDK. The central theme of the CSDDRC is mechanisms and measurements of the fibroinflammatory response in gastrointestinal tissues, which reflects Center members’ research in three subthemes: 1) Gut Microbiome, 2) Gastrointestinal and Liver Metabolism, and 3) Gastrointestinal and Liver Injury, each will be headed by a subtheme leader charged with defining the aspirational goals. The CSDDRC structure (three Biomedical Research Cores, a Pilot and Feasibility (P&F) Program, and an Enrichment Program) will provide an unparalleled platform for advancing the science and addressing unmet needs in digestive diseases research to improve patient outcomes. The CSDDRC Cores are: The Administrative Core (Core A) will provide administrative leadership for optimal management and operation of the Cores, P&F projects, and the Enrichment Program, by employing effective performance improvement activities via close communication with Center membership and the Internal and External Advisory Boards of the CSDDRC. The Advanced In Vitro Model Systems Core (Core B) will harness institutional expertise in induced pluripotent stem cell technology to create novel model systems for mechanistic studies and therapy development. The Gnotobiotics and Gut Microbiome Core (Core C) will bring an expanded gnotobiotic facility and advanced microbiome measurement and analysis tools to the institution. The Human Imaging and Biorepository Core (Core D) will enable collection of deeply annotated human biospecimens and quantitative feature analysis of radiologic imaging, as parameters for biologically-driven investigation of disease subtypes, and translation and validation of preclinical findings. Our P&F Program and Enrichment Program will host lectures, meetings, and symposia to facilitate new collaborative research efforts of Center investigators as they address the themes of the CSDDRC, enhance the career development of early-stage investigators and those new to digestive diseases research, and translate novel discoveries in the lab to the clinic. The large patient population at CSMC allows unique opportunities to examine how our discoveries impact clinical care. Leaders of the CSDDRC will use the tools, mechanisms, and resources of the Center to meet its aspirational goals of accelerating translational research and improving the care of patients with digestive disease and liver disorders. We envision that the CSDDRC will provide a sustainable and growing organization for advancing both careers and the science in the digestive diseases field.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $1,283,250 )
2026	2026	CEDARS-SINAI MEDICAL CENTER	8700 BEVERLY BLVD	WEST HOLLYWOOD	CA	90048	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	6/18/2026	NEW	$1,283,250
														Subtotal = $1,283,250

Grand Total All Awards = $1,283,250

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Cedars-Sinai Digestive Diseases Research Center

Award Number: P30DK138899

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/17/2026

PERIOD OF PERFORMANCE END DATE: 05/31/2031

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