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The Cleveland Digestive Diseases Research Core Center (DDRCC)

Award Number: P30DK097948
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/15/2015
PERIOD OF PERFORMANCE END DATE: 01/31/2025

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The Cleveland Digestive Diseases Research Core Center (DDRCC) - CLEVELAND DDRCC OVERALL PROJECT SUMMARY This competitive renewal application is to obtain continued funding for the Cleveland Digestive Diseases Research Core Center (DDRCC), which is a combined effort between Case Western Reserve University (CWRU) and the Cleveland Clinic Foundation (CCF). The Cleveland DDRCC's mission is to: 1) enhance the research capabilities of Center investigators, 2) develop and implement programs to support the independent development of young investigators, 3) attract established investigators not currently involved in digestive disease research to apply their expertise to this important area of investigation, and 4) facilitate the translation of basic research discoveries to the clinical arena. This cross-institutional and multi-disciplinary Center currently includes 47 full members and 35 associate members from 25 different academic departments across CWRU and the CCF, representing a steady expansion during the previous funding cycle. Together, these investigators comprise the Research Base for the Center, which currently consists of $17.3 million in peer- reviewed federal and foundation grants (52 NIH, 5 DOD/VA, 10 private foundation grants) specifically related to the two scientific themes of the Cleveland DDRCC: Digestive Inflammation/Tumorigenesis and Liver Disease/Metabolism. These two programmatic areas have strong historical track records of collaborative investigation at CWRU and the CCF and have shown significant growth in collaboration during the previous funding cycle. The Center enjoys strong institutional support, including a commitment of significant matching funds from both CWRU and the CCF to increase the impact of digestive disease research at both institutions. The Center includes three biomedical research cores to support this strong Research Base: 1) a Biorepository Core, 2) an Histology/Imaging Core, and 3) a Mouse Models Core, all of which have demonstrated high levels of usage by Center members and promoted important scientific discoveries in digestive diseases during the previous funding cycle. Each Core includes both a set of high-volume standard services that are best provided as a shared resource that can optimize cost-efficiency and quality control, as well as more cutting-edge advanced services and technologies that may not otherwise be available to Center investigators. The Core laboratories interface with a Administrative Core, which also supports a successful Pilot and Feasibility Program to promote innovative research projects by investigators who are new to the area of digestive diseases. The Administrative Core oversees the financial management and operation of the Cleveland DDRCC and supports a Clinical Element, as well as a dynamic Enrichment Program that has supported the meetings of the Midwest DDRCC Research Alliance and two Cleveland International Digestive Education and Science (IDEAS) Symposia during the previous funding cycle. The overall objective of the Cleveland DDRCC is to increase the availability of Core resources for Center members, and to foster research, collaborations, and new directions in digestive disease research, leading to important scientific discoveries.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1,171,275 )
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	2/6/2024	NON-COMPETING CONTINUATION	$1,054,149
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	10	5/20/2024	NON-COMPETING CONTINUATION	$117,126
														Subtotal = $1,171,275

Issue Date FY: 2023 ( Subtotal = $1,564,625 )
2023	2023	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	9	5/23/2023	SUPPLEMENT FOR EXPANSION	$393,350
2023	2023	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	9	3/29/2023	NON-COMPETING CONTINUATION	$1,171,275
														Subtotal = $1,564,625

Issue Date FY: 2022 ( Subtotal = $1,271,275 )
2022	2022	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	8	7/29/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2022	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	1/25/2022	NON-COMPETING CONTINUATION	$1,054,148
2022	2022	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	8	3/30/2022	NON-COMPETING CONTINUATION	$117,127
2022	2022	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	8	7/15/2022	SUPPLEMENT FOR EXPANSION	$100,000
														Subtotal = $1,271,275

Issue Date FY: 2021 ( Subtotal = $1,210,991 )
2021	2021	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	7	5/31/2021	SUPPLEMENT FOR EXPANSION	$39,716
2021	2021	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	7	6/4/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2021	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	3/1/2021	NON-COMPETING CONTINUATION	$1,171,275
														Subtotal = $1,210,991

Issue Date FY: 2020 ( Subtotal = $1,164,000 )
2020	2020	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	6	3/16/2020	COMPETING CONTINUATION	$1,164,000
2020	2020	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	6	6/2/2020	COMPETING CONTINUATION	$6,586
2020	2019	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	5	6/2/2020	NON-COMPETING CONTINUATION	-$6,586
														Subtotal = $1,164,000

Issue Date FY: 2019 ( Subtotal = $1,107,191 )
2019	2019	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	5	8/27/2019	NON-COMPETING CONTINUATION	$18,418
2019	2019	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	1/14/2019	NON-COMPETING CONTINUATION	$1,088,773
														Subtotal = $1,107,191

Issue Date FY: 2018 ( Subtotal = $1,104,238 )
2018	2018	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	1/17/2018	NON-COMPETING CONTINUATION	$999,893
2018	2018	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	6/7/2018	NON-COMPETING CONTINUATION	$104,345
														Subtotal = $1,104,238

Issue Date FY: 2017 ( Subtotal = $1,150,945 )
2017	2017	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	1/16/2017	NON-COMPETING CONTINUATION	$999,893
2017	2017	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	3	9/5/2017	SUPPLEMENT FOR EXPANSION	$39,952
2017	2017	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	6/15/2017	NON-COMPETING CONTINUATION	$111,100
														Subtotal = $1,150,945

Issue Date FY: 2016 ( Subtotal = $1,110,993 )
2016	2016	CASE WESTERN RESERVE UNIVERSITY	2040 ADELBERT ROAD	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	2/25/2016	NON-COMPETING CONTINUATION	$1,110,993
														Subtotal = $1,110,993

Issue Date FY: 2015 ( Subtotal = $1,110,993 )
2015	2015	CASE WESTERN RESERVE UNIVERSITY	2040 ADELBERT ROAD	CLEVELAND	OH	44106	CUYAHOGA	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	2/3/2015	NEW	$1,110,993
														Subtotal = $1,110,993

Grand Total All Awards = $11,966,526

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The Cleveland Digestive Diseases Research Core Center (DDRCC)

Award Number: P30DK097948

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/15/2015

PERIOD OF PERFORMANCE END DATE: 01/31/2025

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