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Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease

Award Number: P30DK078392
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2007
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease - PROJECT SUMMARY The overall goal of our Digestive Health Center (DHC): Bench-to-Bedside Research in Pediatric Digestive Disease is to promote research that will yield insights into the fundamental processes and pathogenic mechanisms of digestive disease in children and generate innovative treatment to restore digestive health. The Cores aims are: 1) to strengthen the Research Base and foster collaborations, 2) to catalyze discoveries by giving investigators access to highly innovative Cores, and 3) to develop junior investigators and the future leaders in the field. The last award period of the DHC was very successful, with Core services that evolved to meet the scientific needs of innovative investigators. Our Research Base of 68 investigators attracts $36.5 million of extramural digestive disease-related funds annually; they published 630 articles in the last 4 years. Several Pilot and Feasibility (P/F) Awardees transitioned to R01-funded investigators and the entire research community benefitted from a scientific Enrichment Program presenting the latest advances in digestive disease research. This trajectory of success will be pursued in future years by fostering research and promoting interdivisional and interdepartmental collaboration to maintain a solid critical mass in digestive disease research with a focus on translational research. Specifically, our long-term goals are to improve child health through better diagnosis, treatments and outcomes that will emerge from highly innovative work in our three key focus areas: 1) Mechanisms of Liver Disease modeling, 2) Digestive Disease and Immunity, and 3) Stem Cell and Organoid Modeling of Digestive Diseases. Each focus area brings opportunities for potential impact on the digestive health of children, helps advance the national research agenda, and creates a unique environment to integrate research into patient care. The focus areas are linked by three complementary and uniquely innovative Biomedical Research Cores (Gene Analysis Core, Integrative Morphology Core, and Stem Cell/Organoid Core and Genome Editing Core) and by a Clinical Component of the Administrative Core to facilitate patient-based research. Collectively the Cores and the Clinical Component form a powerful infrastructure that fosters the development of personalized and predictive medical approaches based on the genetics and molecular basis of GI disorders, and of therapies that take into account basic mechanisms of disease. Our working model promotes laboratory discoveries to generate translational research opportunities that lead to validation in patient samples and lead to clinical trials. To strengthen digestive disease research, the DHC will foster collaborations among its investigators and investigators from other disciplines. It will also fund highly promising P/F Projects for junior investigators and will sponsor a dynamic Enrichment Program of scientific seminars, workshops and symposia. With these strategies and an exceptionally supportive institution, the DHC is well positioned to catalyze translational research in pediatric digestive disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,192,500 )
2025	2025	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	19	6/3/2025	NON-COMPETING CONTINUATION	$1,192,500
														Subtotal = $1,192,500

Issue Date FY: 2024 ( Subtotal = $1,192,500 )
2024	2024	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	18	6/21/2024	NON-COMPETING CONTINUATION	$1,192,500
														Subtotal = $1,192,500

Issue Date FY: 2023 ( Subtotal = $1,326,518 )
2023	2023	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	17	5/25/2023	NON-COMPETING CONTINUATION	$1,192,500
2023	2023	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	17	7/21/2023	SUPPLEMENT FOR EXPANSION	$134,018
2023	2022	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	16	3/28/2023	COMPETING CONTINUATION	$170,397
2023	2021	CHILDRENS HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	3/28/2023	NON-COMPETING CONTINUATION	-$170,397
														Subtotal = $1,326,518

Issue Date FY: 2022 ( Subtotal = $1,192,500 )
2022	2022	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	16	7/29/2022	COMPETING CONTINUATION	$0
2022	2022	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	16	5/11/2022	COMPETING CONTINUATION	$1,192,500
														Subtotal = $1,192,500

Issue Date FY: 2021 ( Subtotal = $1,192,500 )
2021	2021	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	15	5/19/2021	NON-COMPETING CONTINUATION	$1,192,500
														Subtotal = $1,192,500

Issue Date FY: 2020 ( Subtotal = $1,156,726 )
2020	2020	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	14	4/16/2020	NON-COMPETING CONTINUATION	$1,156,726
														Subtotal = $1,156,726

Issue Date FY: 2019 ( Subtotal = $1,192,500 )
2019	2019	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	13	6/11/2019	NON-COMPETING CONTINUATION	$1,168,650
2019	2019	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	13	8/27/2019	NON-COMPETING CONTINUATION	$23,850
														Subtotal = $1,192,500

Issue Date FY: 2018 ( Subtotal = $1,184,391 )
2018	2018	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	12	6/4/2018	NON-COMPETING CONTINUATION	$1,161,891
2018	2017	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	11	1/19/2018	COMPETING CONTINUATION	$22,500
														Subtotal = $1,184,391

Issue Date FY: 2017 ( Subtotal = $1,170,000 )
2017	2017	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	11	7/27/2017	COMPETING CONTINUATION	$1,170,000
2017	2017	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	11	9/25/2017	COMPETING CONTINUATION	$113,899
2017	2016	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	10	11/17/2016	EXTENSION WITH OR WITHOUT FUNDS	$128,533
2017	2016	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	10	9/25/2017	EXTENSION WITH OR WITHOUT FUNDS	-$113,899
2017	2015	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	9	11/17/2016	NON-COMPETING CONTINUATION	-$128,533
														Subtotal = $1,170,000

Issue Date FY: 2016 ( Subtotal = $1,079,350 )
2016	2016	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	10	6/2/2016	EXTENSION WITH OR WITHOUT FUNDS	$1,079,350
														Subtotal = $1,079,350

Issue Date FY: 2015 ( Subtotal = $1,079,350 )
2015	2015	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	9	5/19/2015	NON-COMPETING CONTINUATION	$1,079,350
														Subtotal = $1,079,350

Issue Date FY: 2014 ( Subtotal = $1,079,350 )
2014	2014	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	8	7/18/2014	NON-COMPETING CONTINUATION	$1,079,350
														Subtotal = $1,079,350

Issue Date FY: 2013 ( Subtotal = $1,027,075 )
2013	2013	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	7	5/24/2013	NON-COMPETING CONTINUATION	$1,027,075
														Subtotal = $1,027,075

Issue Date FY: 2012 ( Subtotal = $1,099,498 )
2012	2012	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	6	4/30/2012	COMPETING CONTINUATION	$1,099,498
														Subtotal = $1,099,498

Issue Date FY: 2011 ( Subtotal = $1,106,775 )
2011	2011	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	6/14/2011	NON-COMPETING CONTINUATION	$1,106,775
														Subtotal = $1,106,775

Issue Date FY: 2010 ( Subtotal = $1,213,220 )
2010	2010	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	5/17/2010	NON-COMPETING CONTINUATION	$1,125,000
2010	2010	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	9/20/2010	SUPPLEMENT FOR EXPANSION	$88,220
														Subtotal = $1,213,220

Issue Date FY: 2009 ( Subtotal = $1,358,994 )
2009	2009	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Trans-NIH Recovery Act Research Support	001	3	7/16/2009	SUPPLEMENT FOR EXPANSION	$294,200
2009	2009	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	6/10/2009	NON-COMPETING CONTINUATION	$1,064,794
														Subtotal = $1,358,994

Issue Date FY: 2008 ( Subtotal = $1,067,337 )
2008	2008	CHILDREN`S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Digestive Diseases and Nutrition Research	000	2	5/28/2008	NON-COMPETING CONTINUATION	$1,067,337
														Subtotal = $1,067,337

Issue Date FY: 2007 ( Subtotal = $1,087,250 )
2007	2007	CHILDREN'S HOSPITAL MEDICAL CENTER	3333 BURNET AVENUE	CINCINNATI	OH	45229	HAMILTON	USA	Digestive Diseases and Nutrition Research	000	1	7/27/2007	NEW	$1,087,250
														Subtotal = $1,087,250

Grand Total All Awards = $21,998,334

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Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease

Award Number: P30DK078392

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2007

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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