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Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID)

Award Number: P30DK042086
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/01/1996
PERIOD OF PERFORMANCE END DATE: 11/30/2025

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Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID) - PROJECT SUMMARY/ABSTRACT The main goal of the University of Chicago (UChicago) Digestive Diseases Research Core Center (DDRCC) for Interdisciplinary Study of Inflammatory Intestinal Disorders (C-IID) is to foster and facilitate interdisciplinary and innovative, patient-oriented, research in the field of complex inflammatory digestive diseases (DD), to understand and therapeutically exploit discoveries to improve the health of patients with DD. The UChicago C-IID is now in its 29th year, and, despite being a highly focused research program, has a multidisciplinary research base, with 46 full and 25 associate member investigators, and a total annual direct funding for DD that has increased by more than 40% since the last funding cycle, with $21.1 million of direct cost (not including funding from associate members). The ongoing CENTRAL HYPOTHESIS is that advances in care of patients with complex inflammatory diseases of the bowel requires a structure that empowers interdisciplinary clinical and discovery research investigating the mechanisms disrupting intestinal homeostasis and driving inflammation to identify therapeutic targets and foster translation of basic discoveries to development of new preventive and curative treatments. Taking-into-account the evolving scientific and technology advances and trends, and the interests of our members, we have re-aligned members around four C-IID cores that embrace four major interrelated research themes: Microbiome & Metabolism, Genetics, Genomics & Computation, Immune & Tissue response, and Translational & Clinical. Our OVERALL SPECIFIC AIMS are to: (i) build a highly collaborative, multidisciplinary team, (ii) identify and foster young investigators working in DD-related research, (iii) build a fully integrated translational research infrastructure with state-of-the-art core facilities and cutting-edge, high quality, and cost-effective services and resources, (iv) support a robust enrichment program, (v) promote interactions between the C-IID and other UChicago NIDDK centers and existing C-IID (especially with the Midwest DDRCC alliance). The C-IID has received tremendous institutional support as 1 of 5 priority areas designated for development by the Biological Sciences Division. The C-IID has successfully supported new investigators, but also drawn in talented scientists outside of the field of DD (8 now full members since 2015). Over the past two funding cycles, the P&F program has resulted in over $20.1M in extramural funds, or a 20 to 1 return- on-investment. Furthermore, 43% of the 322 publications acknowledging the C-IID for its support were coauthored by two or more C-IID members, indicating a high level of collaborative science. There was a 5-fold increase in the number of co-authored high impact papers (Impact factor>15) compared to the previous funding cycle. Thus, the C-IID has successfully met its goals of advancing the science and translation of discovery in inflammatory DD. The C-IID as a whole is greater than the sum of its parts. It provides strategic vision, cutting-edge, high quality, and cost-effective services and resources, and gives opportunity to current and next generation scientists to flourish in a highly collaborative and productive environment.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,107,000 )
2025	2025	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	35	12/3/2024	NON-COMPETING CONTINUATION	$1,107,000
														Subtotal = $1,107,000

Issue Date FY: 2024 ( Subtotal = $1,230,000 )
2024	2024	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	34	2/6/2024	NON-COMPETING CONTINUATION	$1,107,000
2024	2024	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	34	5/17/2024	NON-COMPETING CONTINUATION	$123,000
														Subtotal = $1,230,000

Issue Date FY: 2023 ( Subtotal = $1,230,000 )
2023	2023	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	33	3/29/2023	NON-COMPETING CONTINUATION	$1,230,000
														Subtotal = $1,230,000

Issue Date FY: 2022 ( Subtotal = $1,229,707 )
2022	2022	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	32	1/10/2022	NON-COMPETING CONTINUATION	$1,107,000
2022	2022	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	32	3/30/2022	NON-COMPETING CONTINUATION	$123,000
2022	2021	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	31	7/22/2022	COMPETING CONTINUATION	$9,606
2022	2020	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	30	7/22/2022	NON-COMPETING CONTINUATION	-$9,606
2022	2020	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	30	9/29/2022	NON-COMPETING CONTINUATION	-$293
														Subtotal = $1,229,707

Issue Date FY: 2021 ( Subtotal = $1,230,000 )
2021	2021	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	31	8/8/2021	COMPETING CONTINUATION	$62,901
2021	2021	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	31	6/2/2021	COMPETING CONTINUATION	$15,000
2021	2021	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	31	3/18/2021	COMPETING CONTINUATION	$1,215,000
2021	2020	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	30	8/8/2021	NON-COMPETING CONTINUATION	-$62,901
														Subtotal = $1,230,000

Issue Date FY: 2020 ( Subtotal = $1,149,450 )
2020	2020	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	30	4/3/2020	NON-COMPETING CONTINUATION	$1,149,450
														Subtotal = $1,149,450

Issue Date FY: 2019 ( Subtotal = $1,173,150 )
2019	2019	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	29	8/27/2019	NON-COMPETING CONTINUATION	$11,850
2019	2019	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	29	12/13/2018	NON-COMPETING CONTINUATION	$1,161,300
2019	2018	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	28	11/2/2018	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,173,150

Issue Date FY: 2018 ( Subtotal = $1,206,544 )
2018	2018	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	28	6/7/2018	NON-COMPETING CONTINUATION	$88,042
2018	2018	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	28	8/3/2018	SUPPLEMENT FOR EXPANSION	$52,002
2018	2018	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	28	12/20/2017	NON-COMPETING CONTINUATION	$1,066,500
														Subtotal = $1,206,544

Issue Date FY: 2017 ( Subtotal = $1,185,000 )
2017	2017	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	27	6/14/2017	NON-COMPETING CONTINUATION	$118,500
2017	2017	UNIVERSITY OF CHICAGO, THE	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	27	12/6/2016	NON-COMPETING CONTINUATION	$1,066,500
														Subtotal = $1,185,000

Issue Date FY: 2016 ( Subtotal = $1,185,000 )
2016	2016	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	26	3/11/2016	COMPETING CONTINUATION	$1,185,000
														Subtotal = $1,185,000

Issue Date FY: 2015 ( Subtotal = $1,170,000 )
2015	2015	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	25	12/5/2014	NON-COMPETING CONTINUATION	$1,053,000
2015	2015	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	25	3/6/2015	NON-COMPETING CONTINUATION	$117,000
														Subtotal = $1,170,000

Issue Date FY: 2014 ( Subtotal = $1,170,000 )
2014	2014	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	24	8/7/2014	NON-COMPETING CONTINUATION	$41,685
2014	2014	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	24	3/14/2014	NON-COMPETING CONTINUATION	$92,163
2014	2014	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	24	12/5/2013	NON-COMPETING CONTINUATION	$1,036,152
														Subtotal = $1,170,000

Issue Date FY: 2013 ( Subtotal = $1,089,108 )
2013	2013	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	23	10/29/2012	NON-COMPETING CONTINUATION	$1,036,152
2013	2013	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	23	5/17/2013	NON-COMPETING CONTINUATION	$52,956
														Subtotal = $1,089,108

Issue Date FY: 2012 ( Subtotal = $1,170,000 )
2012	2012	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	22	9/17/2012	NON-COMPETING CONTINUATION	$18,722
2012	2012	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	22	11/18/2011	NON-COMPETING CONTINUATION	$1,036,151
2012	2012	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	22	2/13/2012	NON-COMPETING CONTINUATION	$115,127
														Subtotal = $1,170,000

Issue Date FY: 2011 ( Subtotal = $1,151,280 )
2011	2011	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	21	6/6/2011	COMPETING CONTINUATION	$60,183
2011	2011	UNIVERSITY OF CHICAGO	1225 EAST 60TH ST	CHICAGO	IL	60637	COOK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	21	2/21/2011	COMPETING CONTINUATION	$1,091,097
														Subtotal = $1,151,280

Grand Total All Awards = $31,597,282

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Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID)

Award Number: P30DK042086

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/01/1996

PERIOD OF PERFORMANCE END DATE: 11/30/2025

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