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Integrated Epithelial and Muscosal Biology

Award Number: P30DK034854
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/1997
PERIOD OF PERFORMANCE END DATE: 03/31/2027

Group Awards By:

View Award Description

Integrated Epithelial and Muscosal Biology - Project Summary The Harvard Digestive Disease Center (HDDC) is a community of 66 Principal (Full) Members with over $39M annual funding for research directly related to the digestive diseases (this is our Research Base, 31% NIDDK). Center members focus on understanding the cell, tissue, and developmental biology of the mucosal surfaces lining the alimentary tract: this is the Center’s Theme. We address the fundamental mechanisms that underlie normal digestive tract function and the pathogenesis of digestive diseases. Center members work in 4 major Research Areas that address the basis for most diseases of the alimentary tract: n Cell, Developmental, and Stem Cell Biology of the Alimentary Tract; n Innate and Adaptive Mucosal Immunology and Microbial Pathogenesis; n Gut Microbiology and Metabolism; and n Clinical and Translational Human Studies. The Center also includes 55 Affiliate Members (not included in Research Base), who participate in Center activities, use our Cores, but who conduct research that falls outside the theme of the HDDC. Our Members’ resources are amplified through services, equipment and training in 3 Biomedical Cores that provide: (Core B) high-resolution microscopy & histopathology, (Core C) diverse technologies to study epithelial cell function & mucosal immunology, and (Core D) technologies in gnotobiotic mice, microbiological and metabolic analyses. Our Cores helped produce 424 original papers. The HDDC Clinical Component supports clinical and translational GI research through subsidized biostatistical and bio-repository services. The Center fosters scientific collaborations through an Enrichment Program reflecting our theme, including an annual symposium, a biennial regional conference Frontiers in Mucosal Immunology , and monthly seminars and workshops focused on young investigators. The HDDC also promotes careers of young scientists through a competitive Pilot-Feasibility Grant Program that has supported 62 investigators since 2006: 92% were awarded major independent funding within 5 years of their award, and all, but one, remain active in digestive diseases-related research. Center Director Wayne Lencer (PI) and Associate Director Richard Blumberg (Co-PI) are highly accomplished physician-scientists, currently Division Chiefs of Pediatric and Adult GI at two major Harvard teaching hospitals, and both are Directors of NIH-funded T32 training programs in Gastroenterology. They are assisted in HDDC leadership by an Executive Committee that includes all Core Directors and Research Area (Affinity-group) Directors, and guided by an External Advisory Board who are all highly accomplished scientists and leaders in GI-related research. The HDDC’s overarching mission is to foster and expand basic and translational science in digestive diseases by n connecting people, n creating opportunity, and n extending resources.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	40	1/7/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $1,248,678 )
2025	2025	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	40	5/29/2025	NON-COMPETING CONTINUATION	$1,248,678
														Subtotal = $1,248,678

Issue Date FY: 2024 ( Subtotal = $1,248,678 )
2024	2024	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	39	5/10/2024	NON-COMPETING CONTINUATION	$1,248,678
														Subtotal = $1,248,678

Issue Date FY: 2023 ( Subtotal = $1,248,678 )
2023	2023	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	38	4/4/2023	NON-COMPETING CONTINUATION	$1,248,678
														Subtotal = $1,248,678

Issue Date FY: 2022 ( Subtotal = $1,248,678 )
2022	2022	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	37	5/23/2022	NON-COMPETING CONTINUATION	$1,248,678
														Subtotal = $1,248,678

Issue Date FY: 2021 ( Subtotal = $1,604,162 )
2021	2021	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	36	3/26/2021	COMPETING CONTINUATION	$1,325,678
2021	2021	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	004	36	9/25/2021	COMPETING CONTINUATION	$621,813
2021	2021	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	36	6/4/2021	SUPPLEMENT FOR EXPANSION	$278,484
2021	2020	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	35	3/18/2021	NON-COMPETING CONTINUATION	$0
2021	2020	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	35	9/25/2021	NON-COMPETING CONTINUATION	-$621,813
														Subtotal = $1,604,162

Issue Date FY: 2020 ( Subtotal = $1,245,411 )
2020	2020	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	35	2/20/2020	NON-COMPETING CONTINUATION	$77,839
2020	2020	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	35	12/4/2019	NON-COMPETING CONTINUATION	$1,167,572
														Subtotal = $1,245,411

Issue Date FY: 2019 ( Subtotal = $1,284,330 )
2019	2019	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	34	8/27/2019	NON-COMPETING CONTINUATION	$12,973
2019	2019	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	34	1/14/2019	NON-COMPETING CONTINUATION	$1,271,357
														Subtotal = $1,284,330

Issue Date FY: 2018 ( Subtotal = $1,261,366 )
2018	2018	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	33	9/21/2018	NON-COMPETING CONTINUATION	$84,755
2018	2018	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	33	11/27/2017	NON-COMPETING CONTINUATION	$1,176,611
														Subtotal = $1,261,366

Issue Date FY: 2017 ( Subtotal = $1,307,347 )
2017	2017	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	32	2/28/2017	NON-COMPETING CONTINUATION	$1,176,611
2017	2017	CHILDREN'S HOSPITAL CORPORATION, THE	300 LONGWOOD AVE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	32	6/15/2017	NON-COMPETING CONTINUATION	$130,736
														Subtotal = $1,307,347

Issue Date FY: 2016 ( Subtotal = $1,384,348 )
2016	2016	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	31	3/22/2016	COMPETING CONTINUATION	$1,384,348
														Subtotal = $1,384,348

Issue Date FY: 2015 ( Subtotal = $1,310,877 )
2015	2015	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	30	12/3/2014	NON-COMPETING CONTINUATION	$1,179,788
2015	2015	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	30	3/9/2015	NON-COMPETING CONTINUATION	$131,089
														Subtotal = $1,310,877

Issue Date FY: 2014 ( Subtotal = $1,310,877 )
2014	2014	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	29	9/3/2014	NON-COMPETING CONTINUATION	$178,839
2014	2014	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	29	12/16/2013	NON-COMPETING CONTINUATION	$1,052,028
2014	2014	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	29	3/17/2014	NON-COMPETING CONTINUATION	$80,010
														Subtotal = $1,310,877

Issue Date FY: 2013 ( Subtotal = $1,104,626 )
2013	2013	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	28	5/21/2013	NON-COMPETING CONTINUATION	$52,598
2013	2013	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	28	11/5/2012	NON-COMPETING CONTINUATION	$1,052,028
														Subtotal = $1,104,626

Issue Date FY: 2012 ( Subtotal = $1,196,252 )
2012	2012	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	27	9/26/2012	NON-COMPETING CONTINUATION	$17,000
2012	2012	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	27	2/28/2012	NON-COMPETING CONTINUATION	$1,179,252
														Subtotal = $1,196,252

Issue Date FY: 2011 ( Subtotal = $1,263,398 )
2011	2011	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	26	3/7/2011	COMPETING CONTINUATION	$1,192,995
2011	2011	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	26	6/7/2011	COMPETING CONTINUATION	$70,403
2011	2010	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	25	3/3/2011	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,263,398

Issue Date FY: 2010 ( Subtotal = $1,258,766 )
2010	2010	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	25	5/21/2010	NON-COMPETING CONTINUATION	$0
2010	2010	CHILDREN'S HOSPITAL CORPORATION	300 LONGWOOD AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	25	4/6/2010	NON-COMPETING CONTINUATION	$1,258,766
														Subtotal = $1,258,766

Grand Total All Awards = $31,419,247

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Integrated Epithelial and Muscosal Biology

Award Number: P30DK034854

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/1997

PERIOD OF PERFORMANCE END DATE: 03/31/2027

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