Thursday, November 21, 2024 11/21/2024

Multimodal Federated Learning for Pan-Cancer Detection of Cachexia and Early Detection of Pancreatic Cancer

Award Number: P30CA076292
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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View Award Abstract

Cancer-associated cachexia and pancreatic ductal adenocarcinoma (PDAC) represent two significant challenges in oncology. Cachexia, a severe syndrome characterized by weight loss and muscle atrophy, dramatically worsens patient outcomes across various cancers. Early detection of cachexia is essential for improving quality of life and survival rates. Concurrently, PDAC is one of the deadliest forms of cancer, often arising from intraductal papillary mucinous neoplasms (IPMNs), which are pancreatic cysts with malignant potential. Accurate risk stratification of IPMNs is crucial for early intervention. Both conditions necessitate advanced predictive models that leverage diverse data sources while ensuring patient privacy. The overarching goal of this proposal is to develop and validate privacy-preserving multimodal machine/deep learning (ML/DL) models for the early detection of cachexia across multiple cancer types and risk stratification of PDAC from IPMNs using clinical, imaging, genetic mutational, and social determinants of health (SDOH) data. To access large-scale representative data while respecting the privacy and the security of sensitive patient data, this proposal leverages Federated Learning (FL). This advanced ML paradigm enables the development of robust predictive models across multiple institutions without centralizing data. FL allows each participating institution to train models locally on their own datasets, sharing only model parameters (e.g., weights and gradients) with a central server. This approach maintains data confidentiality and complies with privacy regulations such as HIPAA and GDPR. By aggregating model updates from multiple sites, FL enhances the diversity and generalizability of the models, reducing biases and improving performance across different populations. Aim 1: Develop a multimodal artificial intelligence (AI) model for the early detection of cachexia in cancer patients using clinical data, imaging biomarkers from abdominal computed tomography (CT) scans, and SDOH for pancreatic, colorectal, gastrointestinal, and ovarian cancers. Aim 2: Develop a multimodal predictive model for risk stratification of IPMNs to identify those most likely to progress to invasive pancreatic malignancy using imaging, clinical, patient-specific risk factors, SDOH, histopathology, and genetic mutational data. The federated model’s performance will be benchmarked between sites and the centralized model using F1 score, AUROC, and accuracy metrics. The successful completion of these aims will enhance the early detection of cachexia and risk stratification for PDAC, ultimately leading to better patient outcomes. We are fully prepared to comply with all the administrative requirements outlined in the FOA. Our team has deployed NVIDIA-FLARE and OpenFL with PyTorch and NumPy on Moffitt’s AI cluster and is conducting FL studies. Our NVIDIA-FLARE environment will support FL model training as client and server.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$14,698 )
2025	2021	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 USF MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	000	23	10/1/2024	SUPPLEMENT FOR EXPANSION	-$14,698
														Subtotal = -$14,698

Issue Date FY: 2024 ( Subtotal = $4,517,876 )
2024	2024	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 USF MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	001	26	1/29/2024	SUPPLEMENT FOR EXPANSION	$137,979
2024	2024	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 USF MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	000	26	1/26/2024	NON-COMPETING CONTINUATION	$3,794,807
2024	2024	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 USF MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	006	26	9/6/2024	SUPPLEMENT FOR EXPANSION	$202,200
2024	2024	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 USF MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	003	26	3/8/2024	NON-COMPETING CONTINUATION	-$145,467
2024	2024	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 USF MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	002	26	1/30/2024	SUPPLEMENT FOR EXPANSION	$122,875
2024	2024	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 USF MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	004	26	4/17/2024	NON-COMPETING CONTINUATION	$356,291
2024	2024	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 USF MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	005	26	5/20/2024	NON-COMPETING CONTINUATION	$49,191
														Subtotal = $4,517,876

Issue Date FY: 2023 ( Subtotal = $5,011,366 )
2023	2023	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	004	25	2/14/2023	SUPPLEMENT FOR EXPANSION	$169,651
2023	2023	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	002	25	2/10/2023	NON-COMPETING CONTINUATION	$4,054,822
2023	2023	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	006	25	9/7/2023	SUPPLEMENT FOR EXPANSION	$299,999
2023	2023	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	005	25	8/16/2023	SUPPLEMENT FOR EXPANSION	$249,906
2023	2023	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	003	25	2/13/2023	SUPPLEMENT FOR EXPANSION	$236,988
2023	2022	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	001	24	12/7/2022	SUPPLEMENT FOR EXPANSION	$0
2023	2022	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	000	24	10/19/2022	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $5,011,366

Issue Date FY: 2022 ( Subtotal = $4,850,082 )
2022	2022	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	009	24	9/1/2022	SUPPLEMENT FOR EXPANSION	$18,513
2022	2022	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	011	24	9/22/2022	SUPPLEMENT FOR EXPANSION	$104,167
2022	2022	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	001	24	5/3/2022	SUPPLEMENT FOR EXPANSION	$57,009
2022	2022	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	010	24	9/21/2022	SUPPLEMENT FOR EXPANSION	$100,561
2022	2022	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	002	24	5/12/2022	SUPPLEMENT FOR EXPANSION	$250,000
2022	2022	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	012	24	9/23/2022	SUPPLEMENT FOR EXPANSION	$149,999
2022	2022	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	008	24	7/5/2022	COMPETING CONTINUATION	$252,149
2022	2022	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	003	24	5/13/2022	SUPPLEMENT FOR EXPANSION	$115,000
2022	2022	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	000	24	1/31/2022	COMPETING CONTINUATION	$4,054,833
2022	2021	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	007	23	7/5/2022	SUPPLEMENT FOR EXPANSION	-$22,569
2022	2021	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	006	23	7/5/2022	SUPPLEMENT FOR EXPANSION	-$60,000
2022	2021	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	004	23	7/5/2022	SUPPLEMENT FOR EXPANSION	-$104,770
2022	2021	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	005	23	7/5/2022	SUPPLEMENT FOR EXPANSION	-$64,810
														Subtotal = $4,850,082

Issue Date FY: 2021 ( Subtotal = $3,573,809 )
2021	2021	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	009	23	9/13/2021	SUPPLEMENT FOR EXPANSION	$22,569
2021	2021	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	004	23	5/19/2021	SUPPLEMENT FOR EXPANSION	$250,000
2021	2021	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	007	23	5/24/2021	SUPPLEMENT FOR EXPANSION	$60,000
2021	2021	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	006	23	5/21/2021	SUPPLEMENT FOR EXPANSION	$64,810
2021	2021	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	002	23	5/3/2021	NON-COMPETING CONTINUATION	$2,990,966
2021	2021	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Treatment Research	003	23	5/18/2021	SUPPLEMENT FOR EXPANSION	$57,500
2021	2021	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	008	23	6/10/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2021	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	005	23	5/20/2021	SUPPLEMENT FOR EXPANSION	$127,964
2021	2020	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	001	22	12/11/2020	SUPPLEMENT FOR EXPANSION	$0
2021	2020	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	000	22	12/11/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $3,573,809

Issue Date FY: 2020 ( Subtotal = $3,584,392 ) (Continued on the next page)
2020	2020	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	007	22	3/19/2020	SUPPLEMENT FOR EXPANSION	$125,000
2020	2020	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	009	22	9/21/2020	SUPPLEMENT FOR EXPANSION	$149,981
2020	2020	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	005	22	2/27/2020	NON-COMPETING CONTINUATION	$2,990,966
2020	2020	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	010	22	9/22/2020	SUPPLEMENT FOR EXPANSION	$99,999
2020	2020	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	Cancer Centers Support Grants	008	22	8/26/2020	SUPPLEMENT FOR EXPANSION	$103,446
2020	2020	H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE HOSPITAL, INC.	12902 MAGNOLIA DR	TAMPA	FL	33612	HILLSBOROUGH	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	006	22	3/18/2020	SUPPLEMENT FOR EXPANSION	$115,000
Grand Total All Awards = $83,841,572

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Multimodal Federated Learning for Pan-Cancer Detection of Cachexia and Early Detection of Pancreatic Cancer

Award Number: P30CA076292

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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