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An Accurate Machine Learning Framework for Childhood Acute Myeloid Leukemia Subtype Identification by Integrating Bulk and Single-Cell Multi-Omics Data Within and Beyond the CCDI Ecosystem

Award Number: P30CA036727
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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An Accurate Machine Learning Framework for Childhood Acute Myeloid Leukemia Subtype Identification by Integrating Bulk and Single-Cell Multi-Omics Data Within and Beyond the CCDI Ecosystem - PROJECT SUMMARY The Fred & Pamela Buffett Cancer Center (Buffett Cancer Center or BCC), an NCI-designated Cancer Center since 1984, is committed to basic, translational, clinical and population science research, comprehensive educational programs, and outreach to underserved communities in our catchment area (Nebraska). The new BCC integrated cancer research and care facility increased Cancer Center-controlled research space 1.7-fold (total 400,000 sq ft), creating an environment which fosters scientific innovation and transdisciplinary collaborations. The Cancer Center is fully integrated into the university and its affiliated healthcare network, Nebraska Medicine (NM), with the Director reporting directly to the UNMC Chancellor and CEO NM and appointed BCC Physician-in-Chief. Two Cancer Center leadership positions were established since the last review, Deputy Director and Associate Director for Community Outreach and Engagement (COE), with the latter leading efforts to reduce cancer burden and disparities in diverse communities across Nebraska. The BCC also appointed four new senior leaders and eliminated dual leadership roles to promote clinical and translational research. The centralization, expansion and reorganization of the BCC Clinical Trials Office was completed and a new CTMS (OnCore) installed, culminating in a 1.8-fold increase in accrual to interventional clinical trials. Research infrastructure was enhanced by the addition of a new Preclinical Imaging Shared Resource as well as several new resources (e.g., Metabolomics, Organoids, Patient-Derived Models, Tissue Microarrays, Synthetic and Medicinal Chemistry, and Computational Chemistry). The BCC has three Research Programs: Cancer Biology Program (CBP); Targets, Modulators and Delivery Program (TMDP); and GI Cancer Program (GICP). Two programs, CBP and TMDP, changed names, reflecting the strategic realignment of their missions, themes and memberships. With 28 Members recruited during the current funding period, the BCC has a robust track record of clinical and translational research supported by 14 multidisciplinary awards (P01, P50, P20s, U awards; 6 from NCI) and 16 new MPI awards (11 from NCI). Cancer-relevant peer-reviewed research funding in the BCC increased 1.4-fold to $25.3M (Annual Direct Costs) and NCI funding increased 1.3-fold to $12.5 M (Annual Direct Costs) since our last review.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $2,893,786 )
2024	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	009	38	9/13/2024	SUPPLEMENT FOR EXPANSION	$200,000
2024	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	007	38	9/11/2024	SUPPLEMENT FOR EXPANSION	$191,875
2024	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	006	38	8/13/2024	NON-COMPETING CONTINUATION	$2,401,911
2024	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	008	38	9/12/2024	SUPPLEMENT FOR EXPANSION	$100,000
2024	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	002	37	4/23/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	003	37	4/23/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	000	37	4/23/2024	NON-COMPETING CONTINUATION	$0
2024	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	010	37	9/25/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	004	37	4/23/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	001	37	4/23/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	005	37	4/23/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,893,786

Issue Date FY: 2023 ( Subtotal = $3,517,901 )
2023	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	003	37	9/11/2023	NON-COMPETING CONTINUATION	$2,401,911
2023	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	007	37	9/20/2023	SUPPLEMENT FOR EXPANSION	$200,000
2023	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	005	37	9/13/2023	SUPPLEMENT FOR EXPANSION	$125,000
2023	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	006	37	9/19/2023	SUPPLEMENT FOR EXPANSION	$100,000
2023	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	008	37	9/26/2023	SUPPLEMENT FOR EXPANSION	$500,000
2023	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	004	37	9/12/2023	SUPPLEMENT FOR EXPANSION	$191,875
2023	2021	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	002	35	4/11/2023	COMPETING CONTINUATION	-$45,608
2023	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Detection and Diagnosis Research	000	33	10/11/2022	SUPPLEMENT FOR EXPANSION	-$885
2023	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	001	34	4/11/2023	NON-COMPETING CONTINUATION	$45,608
														Subtotal = $3,517,901

Issue Date FY: 2022 ( Subtotal = $2,783,161 )
2022	2022	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	003	36	9/1/2022	NON-COMPETING CONTINUATION	$2,401,911
2022	2022	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Detection and Diagnosis Research	002	33	7/5/2022	SUPPLEMENT FOR EXPANSION	$381,250
2022	2021	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	001	35	1/12/2022	COMPETING CONTINUATION	$45,608
2022	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	000	34	1/12/2022	NON-COMPETING CONTINUATION	-$45,608
														Subtotal = $2,783,161

Issue Date FY: 2021 ( Subtotal = $2,015,027 )
2021	2021	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	002	35	9/21/2021	COMPETING CONTINUATION	$2,395,392
2021	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Detection and Diagnosis Research	001	33	4/7/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Detection and Diagnosis Research	000	33	3/10/2021	SUPPLEMENT FOR EXPANSION	-$380,365
														Subtotal = $2,015,027

Issue Date FY: 2020 ( Subtotal = $2,488,250 )
2020	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Detection and Diagnosis Research	000	33	6/30/2020	SUPPLEMENT FOR EXPANSION	$381,250
2020	2020	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	001	34	7/31/2020	NON-COMPETING CONTINUATION	$2,107,000
														Subtotal = $2,488,250

Issue Date FY: 2019 ( Subtotal = $2,107,000 )
2019	2019	UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	000	33	7/22/2019	NON-COMPETING CONTINUATION	$2,107,000
														Subtotal = $2,107,000

Issue Date FY: 2018 ( Subtotal = $2,075,035 )
2018	2018	UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	000	32	8/2/2018	NON-COMPETING CONTINUATION	$2,075,035
														Subtotal = $2,075,035

Issue Date FY: 2017 ( Subtotal = $2,107,000 )
2017	2017	UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	003	31	7/31/2017	NON-COMPETING CONTINUATION	$2,107,000
2017	2016	UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	002	30	1/31/2017	COMPETING CONTINUATION	$140,348
2017	2015	UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	001	29	1/31/2017	SUPPLEMENT FOR EXPANSION	-$89,185
2017	2015	UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	000	29	1/31/2017	NON-COMPETING CONTINUATION	-$51,163
														Subtotal = $2,107,000

Issue Date FY: 2016 ( Subtotal = $2,221,625 )
2016	2016	UNIVERSITY OF NEBRASKA MEDICAL CENTER	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	001	30	8/5/2016	SUPPLEMENT FOR EXPANSION	$50,000
2016	2016	UNIVERSITY OF NEBRASKA MEDICAL CENTER	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	002	30	9/13/2016	SUPPLEMENT FOR EXPANSION	$64,625
2016	2016	UNIVERSITY OF NEBRASKA MEDICAL CENTER	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	000	30	7/25/2016	COMPETING CONTINUATION	$2,107,000
														Subtotal = $2,221,625

Issue Date FY: 2015 ( Subtotal = $1,574,185 )
2015	2015	UNIVERSITY OF NEBRASKA MEDICAL CENTER	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	001	29	8/17/2015	SUPPLEMENT FOR EXPANSION	$89,185
2015	2015	UNIVERSITY OF NEBRASKA MEDICAL CENTER	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Cancer Centers Support Grants	000	29	8/14/2015	NON-COMPETING CONTINUATION	$1,485,000
														Subtotal = $1,574,185

Grand Total All Awards = $48,992,293

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An Accurate Machine Learning Framework for Childhood Acute Myeloid Leukemia Subtype Identification by Integrating Bulk and Single-Cell Multi-Omics Data Within and Beyond the CCDI Ecosystem

Award Number: P30CA036727

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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