Wednesday, February 5, 2025 2/5/2025

Cancer Center Support Grant

Award Number: P30CA016086
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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ABSTRACT Over the past 5 years, the Center sustained its upward trajectory in cancer research excellence and service to its catchment area, the State of North Carolina. With Dr Sharpless’s appointment to NCI Director, in consultation with University leadership and the Center’s Scientific Advisors, Dr Earp was re-appointed UNC Lineberger Comprehensive Cancer Center (LCCC) Director for an additional term. The LCCC continued its exceptional performance of the past decade with respect to all important metrics including state service. Direct cost cancer research funding in 2019 increased to $161M of which over $54M comes from NCI; Center research space under the Director’s authority increased by ~10,000nsf; participation in interventional trials was over 11,000 accruals for the 5 year period; 36% of the more than 6,000 cancer related publication were collaborative; construction of a GMP facility was begun and a CAR T program was initiated with multiple INDs and 8 trials opened; and the Office of Community Outreach Engagement expanded LCCC’s traditional strength in community-based participatory research and implementation . The Center’s 324 members span the basic, clinical and population sciences organized into 9 programs with substantial inter- and intra-programmatic productivity. Faculty additions in the physical and pharmaceutical sciences created new opportunities in drug discovery, delivery, imaging and early detection. Substantial investment in faculty, technology and bioinformatics dramatically expanded cancer genetics research including leadership in the TCGA and expanded use of sequencing in clinical trials. LCCC population scientists initiated significant new efforts in cancer outcomes with recruitment and infrastructure for analyzing all cancer cases in our catchment area, as well as new endeavors in cancer communication, health access, survivorship and molecular epidemiology. Groundbreaking observations in breast cancer minority disparity research emerged from Center programs. Our basic programs continue to publish high-impact observations that are being translated into human therapeutics. A trans-Center Global Oncology effort received grants in each of the NCI’s new competitions. The Center’s continued expansion is driven by remarkable institutional support including direct support for cancer research from the state legislature. The UNC Lineberger requests continued funding for: 9 scientific programs; 13 shared resources; Clinical Protocol and Data Management; Protocol Review and Monitoring System, Developmental Funds, Planning, Leadership and Evaluation and Cancer Research and Career Enhancement The CCSG budget supports technological and operational expansion for a talented faculty integrated through cancer center mechanisms towards making advancements in the prevention, early detection, and treatment of cancer in North Carolina and the nation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $7,402,429 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	49	12/5/2024	NON-COMPETING CONTINUATION	$7,044,854
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	001	49	12/9/2024	SUPPLEMENT FOR EXPANSION	$357,575
2025	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	002	48	1/20/2025	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $7,402,429

Issue Date FY: 2024 ( Subtotal = $8,179,039 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	002	48	1/24/2024	SUPPLEMENT FOR EXPANSION	$21,059
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	001	48	12/6/2023	SUPPLEMENT FOR EXPANSION	$189,538
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	004	48	8/27/2024	SUPPLEMENT FOR EXPANSION	$140,827
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	48	12/4/2023	NON-COMPETING CONTINUATION	$7,044,854
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	003	48	4/17/2024	NON-COMPETING CONTINUATION	$782,761
														Subtotal = $8,179,039

Issue Date FY: 2023 ( Subtotal = $8,046,820 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	001	47	1/30/2023	SUPPLEMENT FOR EXPANSION	$219,205
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	47	1/24/2023	NON-COMPETING CONTINUATION	$7,827,615
														Subtotal = $8,046,820

Issue Date FY: 2022 ( Subtotal = $8,268,851 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	002	46	12/23/2021	SUPPLEMENT FOR EXPANSION	$121,038
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	001	46	12/8/2021	SUPPLEMENT FOR EXPANSION	$250,000
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	46	12/2/2021	NON-COMPETING CONTINUATION	$7,827,615
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	003	46	8/23/2022	SUPPLEMENT FOR EXPANSION	$70,198
														Subtotal = $8,268,851

Issue Date FY: 2021 ( Subtotal = $8,465,833 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	007	45	9/10/2021	SUPPLEMENT FOR EXPANSION	$104,166
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	008	45	9/21/2021	SUPPLEMENT FOR EXPANSION	$138,311
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	001	45	5/19/2021	COMPETING CONTINUATION	$454,752
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	45	12/21/2020	COMPETING CONTINUATION	$7,827,615
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	005	45	7/13/2021	SUPPLEMENT FOR EXPANSION	$145,834
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	006	45	7/26/2021	SUPPLEMENT FOR EXPANSION	$249,907
2021	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	003	44	5/19/2021	SUPPLEMENT FOR EXPANSION	-$148,751
2021	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	002	44	5/19/2021	SUPPLEMENT FOR EXPANSION	-$115,316
2021	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	004	44	5/19/2021	SUPPLEMENT FOR EXPANSION	-$190,685
														Subtotal = $8,465,833

Issue Date FY: 2020 ( Subtotal = $8,104,247 )
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	005	44	9/17/2020	SUPPLEMENT FOR EXPANSION	$190,685
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	004	44	8/28/2020	SUPPLEMENT FOR EXPANSION	$148,751
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	001	44	3/24/2020	SUPPLEMENT FOR EXPANSION	$250,000
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	003	44	8/24/2020	SUPPLEMENT FOR EXPANSION	$128,939
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	44	12/24/2019	NON-COMPETING CONTINUATION	$7,252,540
2020	2020	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	002	44	3/25/2020	SUPPLEMENT FOR EXPANSION	$133,332
														Subtotal = $8,104,247

Issue Date FY: 2019 ( Subtotal = $7,721,839 )
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	003	43	9/13/2019	SUPPLEMENT FOR EXPANSION	$104,166
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	001	43	12/19/2018	SUPPLEMENT FOR EXPANSION	$187,497
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	002	43	2/19/2019	SUPPLEMENT FOR EXPANSION	$110,970
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	004	43	9/17/2019	SUPPLEMENT FOR EXPANSION	$66,666
2019	2019	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	43	12/10/2018	NON-COMPETING CONTINUATION	$7,252,540
														Subtotal = $7,721,839

Issue Date FY: 2018 ( Subtotal = $7,789,374 ) (Continued on the next page)
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	007	42	9/12/2018	SUPPLEMENT FOR EXPANSION	$41,000
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	003	42	4/11/2018	SUPPLEMENT FOR EXPANSION	$63,060
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	000	42	12/15/2017	NON-COMPETING CONTINUATION	$6,527,287
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	008	42	9/17/2018	SUPPLEMENT FOR EXPANSION	$89,030
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	006	42	5/25/2018	SUPPLEMENT FOR EXPANSION	$24,999
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	001	42	2/23/2018	SUPPLEMENT FOR EXPANSION	$84,375
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Cancer Centers Support Grants	005	42	5/24/2018	SUPPLEMENT FOR EXPANSION	$9,375
2018	2018	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	21st Century Cures Act - Beau Biden Cancer Moonshot	002	42	2/26/2018	SUPPLEMENT FOR EXPANSION	$224,995
Grand Total All Awards = $188,293,778

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Cancer Center Support Grant

Award Number: P30CA016086

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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