Tuesday, February 4, 2025 2/4/2025

Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR)

Award Number: P30AI036219
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY– RUSTBELT CFAR UGANDA CORE C Revision Overall The RUSTBELT CFAR is the only CFAR to have a robust international core, the Uganda Core C, which runs advanced virology and immunology laboratories at the Joint Clinical Research Centre (JCRC) in Kampala, Uganda, and has long been the centerpiece of the CFAR. We have expanded Uganda's highly productive and unique CFAR activities to include technology transfer of advanced drug resistance, HIV cure, somatic mutation and DNA methylation assays, and advanced clinical virology tools developed by Pitt. The “RUSTBELT CFAR Ugandan Faculty Development Program” will be an intensive two-year experience providing start-up funds, pilot grant awards, salary support, and intensive mentoring in Uganda and through exchange visits to RUSTBELT CFAR laboratories and Cores. We anticipate sponsoring 3 translational investigators or clinical investigators during the current iteration of the Rustbelt CFAR, which is funded until 04/30/2027. Participants’ career development will be fostered by dual mentorship between Ugandan and Rustbelt CFAR mentors, opportunities for hands-on experiences in clinical studies, and coaching and collaboration in preparing competitive NIH grant proposals. Support for faculty development in Uganda will not simply be restricted to Core C activities in Uganda since the entire CFAR clinical and laboratory infrastructure will be used to support technology transfer and promote research with our Ugandan colleagues. We have included annual working visits to the US to promote technology transfer, advanced training, and expansion of collaborative activities. The Clinical Services Core D will provide insights into the maintenance of highly curated clinical specimens and rigorous sample acquisition for translational studies. Our laboratory-based cores, Viral Pathogenesis & Persistence Core E and Systems Biology & Biostatistics Core F, draw on research strengths from both institutions and offer access to cutting-edge emerging technologies for transcriptome and reservoir analyses. Expertise in HIV prevention (SWG2) and sex-based differences in HIV pathogenesis and cure (SWG1) will add new dimensions to Core C’s clinical research opportunities in Uganda. USTBELT CFAR investigators have greatly benefited from attracting talented young investigators from Uganda for advanced training and research in our laboratories. In addition to exposing us to different perspectives on the challenges of the AIDS epidemic from people living and working at one of its epicenters, we benefit from their skills and dedication to research. This new initiative will substantially ameliorate the chronic underrepresentation of translational and clinical researchers from low- and middle-income countries and enhance the diversity of investigators focusing on HIV- focused clinical and translational studies throughout the CFAR.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $4,323,009 )
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	005	28	9/11/2024	SUPPLEMENT FOR EXPANSION	$959,560
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	003	28	5/21/2024	SUPPLEMENT FOR EXPANSION	$238,501
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	002	28	5/20/2024	SUPPLEMENT FOR EXPANSION	$238,013
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	004	28	9/10/2024	SUPPLEMENT FOR EXPANSION	$395,644
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	000	28	5/16/2024	NON-COMPETING CONTINUATION	$2,250,000
2024	2024	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	001	28	5/17/2024	SUPPLEMENT FOR EXPANSION	$241,291
														Subtotal = $4,323,009

Issue Date FY: 2023 ( Subtotal = $3,115,418 )
2023	2023	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	004	27	9/6/2023	SUPPLEMENT FOR EXPANSION	$241,291
2023	2023	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	003	27	8/31/2023	NON-COMPETING CONTINUATION	$161,000
2023	2023	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	006	27	9/8/2023	SUPPLEMENT FOR EXPANSION	$240,018
2023	2023	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	005	27	9/7/2023	SUPPLEMENT FOR EXPANSION	$223,109
2023	2023	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	002	27	6/26/2023	NON-COMPETING CONTINUATION	$2,250,000
2023	2022	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	001	26	6/6/2023	COMPETING CONTINUATION	$116,847
2023	2020	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	000	25	6/6/2023	SUPPLEMENT FOR EXPANSION	-$116,847
														Subtotal = $3,115,418

Issue Date FY: 2022 ( Subtotal = $2,411,000 )
2022	2022	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	001	26	9/8/2022	COMPETING CONTINUATION	$281,600
2022	2022	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	000	26	4/29/2022	COMPETING CONTINUATION	$2,129,400
														Subtotal = $2,411,000

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2019	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	000	25	4/7/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $820,137 )
2020	2020	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	001	25	5/5/2020	SUPPLEMENT FOR EXPANSION	$820,137
2020	2019	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	000	25	5/4/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $820,137

Issue Date FY: 2019 ( Subtotal = $1,799,475 )
2019	2019	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	001	25	8/27/2019	NON-COMPETING CONTINUATION	$159,200
2019	2019	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	000	25	5/2/2019	NON-COMPETING CONTINUATION	$1,640,275
														Subtotal = $1,799,475

Issue Date FY: 2018 ( Subtotal = $1,742,394 )
2018	2018	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	002	24	8/10/2018	NON-COMPETING CONTINUATION	$0
2018	2018	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	000	24	4/25/2018	NON-COMPETING CONTINUATION	$1,640,275
2018	2018	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	001	24	8/9/2018	NON-COMPETING CONTINUATION	$102,119
														Subtotal = $1,742,394

Issue Date FY: 2017 ( Subtotal = $1,818,041 )
2017	2017	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	000	23	4/7/2017	NON-COMPETING CONTINUATION	$1,505,971
2017	2017	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	002	23	8/3/2017	NON-COMPETING CONTINUATION	$177,766
2017	2017	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	003	23	8/24/2017	NON-COMPETING CONTINUATION	$0
2017	2017	CASE WESTERN RESERVE UNIVERSITY	10900 EUCLID AVE	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	001	23	7/25/2017	NON-COMPETING CONTINUATION	$134,304
														Subtotal = $1,818,041

Issue Date FY: 2016 ( Subtotal = $1,644,237 )
2016	2016	CASE WESTERN RESERVE UNIVERSITY	2040 ADELBERT ROAD	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	000	21	3/10/2016	SUPPLEMENT FOR EXPANSION	$3,963
2016	2016	CASE WESTERN RESERVE UNIVERSITY	2040 ADELBERT ROAD	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	001	22	4/22/2016	NON-COMPETING CONTINUATION	$1,640,274
														Subtotal = $1,644,237

Issue Date FY: 2015 ( Subtotal = $1,797,834 )
2015	2015	CASE WESTERN RESERVE UNIVERSITY	2040 ADELBERT ROAD	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	000	21	4/15/2015	COMPETING CONTINUATION	$1,271,480
2015	2015	CASE WESTERN RESERVE UNIVERSITY	2040 ADELBERT ROAD	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	001	21	8/14/2015	COMPETING CONTINUATION	$526,354
														Subtotal = $1,797,834

Issue Date FY: 2014 ( Subtotal = $1,684,814 )
2014	2014	CASE WESTERN RESERVE UNIVERSITY	2040 ADELBERT ROAD	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	000	20	4/23/2014	NON-COMPETING CONTINUATION	$1,684,814
														Subtotal = $1,684,814

Issue Date FY: 2013 ( Subtotal = $1,769,678 )
2013	2013	CASE WESTERN RESERVE UNIVERSITY	2040 ADELBERT ROAD	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	000	19	3/25/2013	NON-COMPETING CONTINUATION	$1,516,331
2013	2013	CASE WESTERN RESERVE UNIVERSITY	2040 ADELBERT ROAD	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	003	19	8/28/2013	NON-COMPETING CONTINUATION	$124,076
2013	2013	CASE WESTERN RESERVE UNIVERSITY	2040 ADELBERT ROAD	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	002	19	8/9/2013	NON-COMPETING CONTINUATION	$61,875
2013	2013	CASE WESTERN RESERVE UNIVERSITY	2040 ADELBERT ROAD	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	001	19	5/30/2013	NON-COMPETING CONTINUATION	$67,396
														Subtotal = $1,769,678

Issue Date FY: 2012 ( Subtotal = $1,841,815 ) (Continued on the next page)
2012	2012	CASE WESTERN RESERVE UNIVERSITY	2040 ADELBERT ROAD	CLEVELAND	OH	44106	CUYAHOGA	USA	Allergy and Infectious Diseases Research	001	18	8/9/2012	NON-COMPETING CONTINUATION	$157,000
Grand Total All Awards = $44,027,248

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Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR)

Award Number: P30AI036219

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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