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UCSD Shiley-Marcos Alzheimer's Disease Research Center P30

Award Number: P30AG062429
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2019
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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UCSD Shiley-Marcos Alzheimer's Disease Research Center P30 - Alzheimer’s disease and related dementias (ADRD) are a growing public health issue with tremendous cost and unfathomable aggregate suffering. Unless the diseases can be effectively treated or prevented, increasing prevalence in an aging population will escalate costs that the country will struggle to bear. With new diagnostics and therapies emerging, there has never been a greater need or opportunity to pursue groundbreaking ADRD research. This application for renewed funding of the UCSD Shiley-Marcos Alzheimer’s Disease Research Center (ADRC) explicitly aligns with the National Alzheimer’s Planning Act (NAPA) and builds on the Center’s 40-year legacy of dynamic research and engagement excellence. The Center’s exceptionally rich academic and community environment, and its commitment to team-science and inclusion, position it to work effectively as a member of the ADRC network toward achievement of national priorities. The Center’s theme and foci are to explore markers, mechanisms, and models to better understand the clinical and pathologic features and heterogeneity of ADRD, and to apply this new knowledge for a diverse, aging population. In particular, we aspire to bring world-class translational neurosciences to the study of heterogeneity and diversity in ADRD. We will develop and apply new markers and models, tailor community- engagement approaches to foster greater participation of diverse populations, and advance culturally sensitive practices in ADRD science relevant to Latinos – a growing demographic group in our region and in the U.S. This work includes innovative human cell model work fostered by its iPSC Core and state-of-the-art approaches in diversity science of its Latino Core that influences and spans Center activities. Integration across all Cores is bolstered by strong institutional commitment to the Center’s continued success and to cutting-edge, disruptive, transdisciplinary team-science. We propose the following overarching aims that reflect and unify our activities in research, education, engagement, and sharing and synergizing with the ADRC network. The Center will: 1) Support integrated, interactive Cores that conduct innovative, interdisciplinary, inclusive team-science research to benefit the diversity of individuals affected by ADRD; 2) Educate, train, and improve preparedness of a more diverse workforce; 3) Serve as a hub for scientific and community exchange and support, applying synergistic Core efforts to engage, inform, and empower patient, caregiver, and research communities; and, 4) Engage deeply in collaborative research across ADRCs and with other NIH-supported initiatives, with special emphasis on applying Center strengths to complement those within the ADRC network and extend its impact.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $4,584,783 )
2026	2026	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Aging Research	001	8	4/28/2026	NON-COMPETING CONTINUATION	$4,584,783
2026	2025	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Aging Research	000	7	1/31/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,584,783

Issue Date FY: 2025 ( Subtotal = $4,616,522 )
2025	2025	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Aging Research	001	7	7/22/2025	NON-COMPETING CONTINUATION	$4,616,522
2025	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Aging Research	000	5	2/11/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,616,522

Issue Date FY: 2024 ( Subtotal = $4,667,513 )
2024	2024	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Aging Research	000	6	6/12/2024	COMPETING CONTINUATION	$4,667,513
														Subtotal = $4,667,513

Issue Date FY: 2023 ( Subtotal = $3,357,075 )
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Aging Research	001	5	5/11/2023	SUPPLEMENT FOR EXPANSION	$306,316
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Aging Research	000	5	5/10/2023	NON-COMPETING CONTINUATION	$3,050,759
														Subtotal = $3,357,075

Issue Date FY: 2022 ( Subtotal = $3,070,424 )
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Aging Research	001	4	5/4/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Aging Research	000	4	4/28/2022	NON-COMPETING CONTINUATION	$3,070,424
														Subtotal = $3,070,424

Issue Date FY: 2021 ( Subtotal = $3,248,425 )
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Aging Research	001	3	5/20/2021	NON-COMPETING CONTINUATION	$3,248,425
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Aging Research	002	3	6/22/2021	NON-COMPETING CONTINUATION	$0
2021	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Aging Research	000	2	10/21/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,248,425

Issue Date FY: 2020 ( Subtotal = $3,653,633 )
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Aging Research	002	2	8/26/2020	SUPPLEMENT FOR EXPANSION	$392,459
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Aging Research	000	2	3/20/2020	NON-COMPETING CONTINUATION	$3,101,316
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Aging Research	003	2	9/1/2020	SUPPLEMENT FOR EXPANSION	$0
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Aging Research	001	2	5/15/2020	SUPPLEMENT FOR EXPANSION	$159,858
														Subtotal = $3,653,633

Issue Date FY: 2019 ( Subtotal = $3,147,902 )
2019	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Aging Research	000	1	5/1/2019	NEW	$3,147,902
														Subtotal = $3,147,902

Grand Total All Awards = $30,346,277

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UCSD Shiley-Marcos Alzheimer's Disease Research Center P30

Award Number: P30AG062429

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2019

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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