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Comparative Bioenergetics of Aging

Award Number: P30AG050886
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2015
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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Comparative Bioenergetics of Aging - Comparative Bioenergetics of Aging (Overall) Project Summary Aging and energetics are inextricably intertwined. That simple, inescapable fact has been clear since the earliest discoveries that long-lived mammal species typically expend cellular energy at a slower rate than short-lived species, that the longevity of poikilothermic animals was inversely related to environmental temperature, hence metabolic rate, that reduced food intake extended life and health in numerous species, and that physical activity was health- and longevity-promoting. Knowledge about the intricate relation between energy flux and aging continues to accumulate. At the organismal level in recent years, for instance, it was discovered that patterns of primate longevity are linked to 24 hour metabolism, that human fat-free mass-adjusted energy expenditure remains constant between ages 20 and 60, and that we had been seriously underestimating the energetic cost of mammalian reproduction, which alters our understanding of the evolution of health and longevity. At a cellular level, we are gaining greater appreciation for the heterogeneity of mitochondrial function, depending on metabolic demand, spatial location in the cell, and cell type among other things. Cellular processes also must be integrated and coordinated across organ systems in response to environmental conditions to ultimately determine how energetics affect health, diseases, and longevity which is the theme of this Nathan Shock Center (NSC). The UAB NSC has taken advantage of its unique strengths in comparative biology of aging, world-class expertise in cellular and tissue bioenergetics, similar expertise in the dissection of whole animal energetics, an exceptionally innovative and adept data analytics core to offer the most comprehensive, integrated energetic assessment and analysis available anywhere from the level of cells to organisms and across species from the size of worms to rats. In this renewal application, the scientific goals of the Center remain to (a) assist emerging scholars in further exploring the complex quantitative links between cellular and organismal energetics, health, and longevity and generalize their findings by model species comparisons, and (b) provide expertise, state-of-the-art instrumentation, and methodologies in comparative energetics analysis to investigators inside and outside of UAB. To achieve these goals, the Center will undertake these specific aims: (1) provide an integrated Center for research, training, and outreach in comparative energetics of geroscience, specifically to facilitate the study of the relationship between energetics from cells to organisms and later life health and longevity. Our three Research Cores are synergistically organized to offer the most comprehensive assessment and analysis of energetics from cells to organisms available anywhere; (2) provide a rich intellectual environment focused on comparative energetics, health, and aging that will foster productive interactions and collaborations among both internal and external investigators from basic aging biology and allied health- and disease-related sub-disciplines; (3) offer assistance, resources, training, and support for new and emerging investigators from allied health- and disease- related sub-disciplines interested in participating in the exciting field of geroscience.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,161,687 )
2025	2025	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	11	6/16/2025	COMPETING CONTINUATION	$1,161,687
2025	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	10	10/23/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,161,687

Issue Date FY: 2024 ( Subtotal = $992,456 )
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	002	10	5/23/2024	NON-COMPETING CONTINUATION	$892,690
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	9	10/26/2023	SUPPLEMENT FOR EXPANSION	$36,756
2024	2024	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH STREET	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	003	10	5/24/2024	SUPPLEMENT FOR EXPANSION	$63,010
2024	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	9	10/25/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $992,456

Issue Date FY: 2023 ( Subtotal = $995,620 )
2023	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	9	5/24/2023	NON-COMPETING CONTINUATION	$892,692
2023	2023	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	002	9	6/16/2023	SUPPLEMENT FOR EXPANSION	$102,928
2023	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	8	11/21/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $995,620

Issue Date FY: 2022 ( Subtotal = $1,272,589 )
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	003	8	6/6/2022	SUPPLEMENT FOR EXPANSION	$371,250
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	002	8	6/2/2022	NON-COMPETING CONTINUATION	$892,690
2022	2022	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	004	8	6/14/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	7	10/21/2021	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	7	11/9/2021	NON-COMPETING CONTINUATION	$0
2022	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	005	5	9/23/2022	NON-COMPETING CONTINUATION	$8,649
														Subtotal = $1,272,589

Issue Date FY: 2021 ( Subtotal = $956,357 )
2021	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	6	2/6/2021	SUPPLEMENT FOR EXPANSION	$21,221
2021	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	005	7	8/5/2021	SUPPLEMENT FOR EXPANSION	$42,445
2021	2021	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	004	7	8/4/2021	NON-COMPETING CONTINUATION	$892,691
2021	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	002	6	2/20/2021	COMPETING CONTINUATION	$79,773
2021	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	003	6	3/12/2021	COMPETING CONTINUATION	$0
2021	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	5	2/20/2021	NON-COMPETING CONTINUATION	-$79,773
														Subtotal = $956,357

Issue Date FY: 2020 ( Subtotal = $892,692 )
2020	2020	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	002	6	9/10/2020	COMPETING CONTINUATION	$892,692
2020	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	5	9/2/2020	NON-COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	5	12/20/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $892,692

Issue Date FY: 2019 ( Subtotal = $506,896 )
2019	2019	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	5	6/25/2019	NON-COMPETING CONTINUATION	$506,896
2019	2018	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	4	11/2/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $506,896

Issue Date FY: 2018 ( Subtotal = $566,719 )
2018	2018	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	4	6/28/2018	NON-COMPETING CONTINUATION	$566,719
														Subtotal = $566,719

Issue Date FY: 2017 ( Subtotal = $568,946 )
2017	2017	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	3	9/18/2017	SUPPLEMENT FOR EXPANSION	$62,050
2017	2017	UNIVERSITY OF ALABAMA AT BIRMINGHAM	701 S 20TH ST	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	3	7/4/2017	NON-COMPETING CONTINUATION	$506,896
														Subtotal = $568,946

Issue Date FY: 2016 ( Subtotal = $606,800 )
2016	2016	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	2	7/15/2016	NON-COMPETING CONTINUATION	$506,896
2016	2016	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	001	2	9/9/2016	SUPPLEMENT FOR EXPANSION	$99,904
														Subtotal = $606,800

Issue Date FY: 2015 ( Subtotal = $506,896 )
2015	2015	UNIVERSITY OF ALABAMA AT BIRMINGHAM	1530 3rd Avenue South, AB 1170	BIRMINGHAM	AL	35294	JEFFERSON	USA	Aging Research	000	1	7/14/2015	NEW	$506,896
														Subtotal = $506,896

Grand Total All Awards = $9,027,658

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Comparative Bioenergetics of Aging

Award Number: P30AG050886

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2015

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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