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Center for Molecular Interactions in Cancer (CMIC)

Award Number: P20GM152281
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/05/2024
PERIOD OF PERFORMANCE END DATE: 12/31/2028

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Center for Molecular Interactions in Cancer (CMIC) - Summary Cancer affects the health of millions of Americans. Studying molecular mechanisms that endow cells with malignant properties is an essential component of advancing pre-clinical studies and a key part of efforts to improve patient outcomes. The purpose of this COBRE submission is to establish the Center for Molecular Interactions in Cancer (CMIC) at the University of Arkansas for Medical Sciences (UAMS). The mission of the CMIC is to study molecular features and functional properties of biomolecules that drive cancer. The unifying theme of research among Center members is the coupling of structural biology and high-resolution imaging with precise, quantitative analysis of biochemical and cellular processes to understand how molecular interactions govern the initiation, progression and treatment of cancer. In Phase 1 of this COBRE, we will pursue the following aims: (Aim 1) establish the CMICcreating an organizational framework that ensures the success of junior investigators as independent scientists and strengthens the research infrastructure at UAMS and its affiliate institutions, (Aim 2) build a thematic, multidisciplinary COBRE center with unique collaborative opportunities and strong research programs focused on understanding the molecular basis of cancer, and (Aim 3) implement a plan for long-term sustainability of the CMIC. The organization of the CMIC will include 5 Research Projects, an Administrative Core, and 2 new research coresthe Structural Biology Core and the Biomolecular Interactions Core. The Administrative Core will oversee operation of the Center, including a Pilot Project Program to fuel the pipeline of replacement Research Project Leaders (RPLs) and a formalized Faculty Development Plan that includes individualized mentoring. The Structural Biology Core will help RPLs plan and execute structure-function studies by ensuring high-quality sample preparation and providing access to world-class instrumentation and computational resources required for high-resolution structural studies. The Biomolecular Interactions Core will enable researchers to perform quantitative analysis of macromolecular interactions and dynamics down to the level of single-molecules. Both research cores will assist users in experimental design, data analysis and interpretation of results, while also providing training and educational outreach. The CMIC will address an institutional priority at UAMS and contribute to the mission of the Winthrop P. Rockefeller Cancer Institute by creating a critical mass of investigators who are able to gain molecular-level insights into mechanisms that are crucial for a deep understanding of cancer biology. Our long-term goal is to leverage faculty mentoring, strategic recruitment, and cutting-edge core resources to develop a critical mass of investigators that will support a self- sustaining center in which research advances our knowledge of cancer through precise and comprehensive analyses of molecular events that impact malignant pathogenesis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,065,501 )
2025	2025	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	2	12/20/2024	NON-COMPETING CONTINUATION	$2,065,501
2025	2024	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	1	12/11/2024	NEW	$0
														Subtotal = $2,065,501

Issue Date FY: 2024 ( Subtotal = $2,295,000 )
2024	2024	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	002	1	8/21/2024	NEW	-$133,875
2024	2024	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	1	8/19/2024	NEW	$133,875
2024	2024	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	1	3/5/2024	NEW	$2,295,000
														Subtotal = $2,295,000

Grand Total All Awards = $4,360,501

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Center for Molecular Interactions in Cancer (CMIC)

Award Number: P20GM152281

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/05/2024

PERIOD OF PERFORMANCE END DATE: 12/31/2028

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