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Center of Biomedical Research Excellence in CNS Metabolism

Award Number: P20GM148326
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2023
PERIOD OF PERFORMANCE END DATE: 02/29/2028

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Center of Biomedical Research Excellence in CNS Metabolism - Central nervous system (CNS) metabolism and neuronal excitability are interdependent, and so CNS metabolism is the biochemical basis of cognition, memory, and behavior. Dysregulation of CNS is implicated in numerous disorders, including Alzheimer’s Disease, epilepsy, Parkinson’s disease, and brain injury, but the mechanistic connections between CNS metabolism and disease are poorly understood. The University of Kentucky (UK) College of Medicine has made significant investments over the last few years in investigators with metabolic and metabolomics expertise and instrumentation to support their research efforts, which has enhanced existing strengths in neuroscience, cancer, cardiovascular, and diabetes and obesity research. Thus, UK proposes to establish a unique multidisciplinary Center of Biomedical Research Excellence (COBRE) on CNS Metabolism (CNS-Met) as a strategically designed, sustainable framework that promotes leading-edge research focused on the role of metabolic mediators of brain function and disease. The proposed interdisciplinary center leverages highly specialized expertise in glucose biology, neuronal signaling, mitochondrial metabolism, systems neuroscience, and data sciences as well as the presence of advanced metabolomics and imaging capabilities to create an integrated research framework focused on CNS metabolism. The overarching goals are to strengthen UK’s neuroscience research enterprise by providing a thematically focused and sustainable multidisciplinary infrastructure dedicated to defining the contribution of metabolism to CNS function and neurological diseases and to use this novel platform to develop promising and highly-skilled, early-stage investigators in an exciting and impactful area of CNS research. To accomplish these goals, we will meet four specific aims: (1) Develop a critical mass of funded investigators with research programs directly related to the COBRE’s unifying theme; (2) provide strong team-based mentoring combining basic and clinical expertise; (3) recruit new investigators to the COBRE in multidisciplinary areas of neurologic dysfunction through pilot project grant and recruitment of junior Research Project Leaders; and (4) create synergy among research projects via critical links to strong research centers and core facilities at UK, including existing COBREs. Emerging synergies will be developed through three research projects, an Administrative Core, a critical research core in Metabolomics, all linked by strong biostatistics/bioinformatics support, all of which are critical to the proposed studies and will contribute to the development of institutional resources. The scientific focus of the three research projects are brain metabolism interactions with neurological disease, spanning basic and translational perspectives. This concentration of multidisciplinary expertise focused on widely recognized yet understudied metabolic mechanisms of neurological diseases promises significant new understandings of CNS metabolism overall. The CNS-Met will create a critical mass of skilled scientists who are well equipped to lead a sustainable research center focused on CNS metabolism into the future.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $2,102,000 )
2026	2026	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	Biomedical Research and Research Training	000	4	2/27/2026	NON-COMPETING CONTINUATION	$2,102,000
														Subtotal = $2,102,000

Issue Date FY: 2025 ( Subtotal = $2,122,307 )
2025	2025	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	Biomedical Research and Research Training	001	3	5/7/2025	NON-COMPETING CONTINUATION	$2,122,307
2025	2024	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	Biomedical Research and Research Training	000	2	12/12/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,122,307

Issue Date FY: 2024 ( Subtotal = $2,130,945 )
2024	2024	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	Biomedical Research and Research Training	000	2	4/22/2024	NON-COMPETING CONTINUATION	$1,917,850
2024	2024	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	Biomedical Research and Research Training	001	2	6/19/2024	NON-COMPETING CONTINUATION	$213,095
														Subtotal = $2,130,945

Issue Date FY: 2023 ( Subtotal = $2,159,837 )
2023	2023	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Biomedical Research and Research Training	000	1	5/15/2023	NEW	$2,159,837
														Subtotal = $2,159,837

Grand Total All Awards = $8,515,089

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Center of Biomedical Research Excellence in CNS Metabolism

Award Number: P20GM148326

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2023

PERIOD OF PERFORMANCE END DATE: 02/29/2028

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