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COBRE: Eukaryotic Pathogens Innovation Center (EPIC)

Award Number: P20GM146584
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2022
PERIOD OF PERFORMANCE END DATE: 05/31/2027

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COBRE: Eukaryotic Pathogens Innovation Center (EPIC) - PROJECT SUMMARY/ABSTRACT Eukaryotic pathogens are the causative agents of some of the most devastating and intractable diseases of humans, including malaria, amebic dysentery, African sleeping sickness, Chagas disease, trichomoniasis, aspergillosis, cryptococcal fungal meningitis, toxoplasmosis and primary amebic meningoencephalitis (PAM). The global impact of these diseases is immense. It is noteworthy that many of these pathogens are the causative agents of neglected tropical diseases (NTDs), neglected diseases of poverty (NDPs) and/or are classified as bioterrorism agents. Importantly, infections caused by eukaryotic pathogens are increasing in the US due to globalization. The primary goal of this COBRE proposal is to increase the number of NIH-funded scientists in the state of South Carolina by supporting a world-class research center, the Eukaryotic Pathogens Innovation Center (EPIC), at Clemson University (CU). The scientific focus of EPIC is a multidisciplinary study of important global eukaryotic pathogens. EPIC is the first-and-only in the state with a focus on infectious diseases, and the first- and-only in the country with a focus on eukaryotic pathogens. Four projects from target junior investigators will be supported. Their projects are 1) Regulation mechanisms of Trypanosome brucei axonemal dynein, 2) Functional roles of ncRNA, afu-182, in azole response and pathobiology of Aspergillus fumigatus, 3) Investigating the function of macrophages in the efficacy of anti-fungal drugs in larval zebrafish, and 4) Evaluating anti-parasitic diazacyclobutenes. These investigators will be matched with external and internal mentors who are established NIH-funded researchers. The projects will be supported by a well-organized Administrative Core and two state-of-the-art Scientific Cores in Genomics, and Imaging/Cell Sorting. The center also has a substantial infrastructure base and significant institutional support. For example, CU will recruit two additional faculty members and two post-doctoral fellows to expand activities of this center over the course of the project period. Pledges of graduate assistantships, equipment, and space further exemplify the institutional commitment. The continuation of this COBRE-funded center will significantly expand research in South Carolina and will facilitate recruitment, training, and retention of a critical mass of investigators with cross-disciplinary skills in this important research area.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $2,183,539 )
2026	2026	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	001	5	7/24/2026	NON-COMPETING CONTINUATION	$2,183,539
2026	2025	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	000	4	6/26/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,183,539

Issue Date FY: 2025 ( Subtotal = $2,194,290 )
2025	2025	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	001	4	7/30/2025	NON-COMPETING CONTINUATION	$2,194,290
2025	2024	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	000	3	1/15/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,194,290

Issue Date FY: 2024 ( Subtotal = $2,204,524 )
2024	2024	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	002	3	7/17/2024	NON-COMPETING CONTINUATION	$0
2024	2024	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	001	3	6/17/2024	NON-COMPETING CONTINUATION	$2,204,524
2024	2023	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	000	2	2/13/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,204,524

Issue Date FY: 2023 ( Subtotal = $2,510,379 )
2023	2023	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	001	2	7/13/2023	NON-COMPETING CONTINUATION	$2,214,268
2023	2023	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	002	2	9/12/2023	SUPPLEMENT FOR EXPANSION	$296,111
2023	2022	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	000	1	1/30/2023	NEW	$0
														Subtotal = $2,510,379

Issue Date FY: 2022 ( Subtotal = $2,209,541 )
2022	2022	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	000	1	7/15/2022	NEW	$2,209,541
														Subtotal = $2,209,541

Grand Total All Awards = $11,302,273

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COBRE: Eukaryotic Pathogens Innovation Center (EPIC)

Award Number: P20GM146584

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2022

PERIOD OF PERFORMANCE END DATE: 05/31/2027

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