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Regulation of Cellular Behavior in Response to Extracellular Cues

Award Number: P20GM144265
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/05/2023
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Regulation of Cellular Behavior in Response to Extracellular Cues - OVERALL ABSTRACT The long-term goal of this Center for Biomedical Research Excellence (COBRE) is to help grow the burgeoning biomedical research industry in Maine by positioning the University of Maine (UMaine) as a biomedical research and training hub that supports and recruits outstanding junior faculty while strengthening our unique statewide graduate program. This COBRE is focused on Regulation of Cellular Behavior in Response to Extracellular Cues. All cells interpret and respond to their environment, yet the mechanisms by which cells process signaling inputs and parse them into discrete cell behaviors are not fully understood. How does G protein coupled receptor signaling regulate polarity in different cell types? How does the extracellular environment regulate muscle cell behaviors such as migration and regeneration? How do viruses modify cells to cause disease? Five research projects led by early career investigators from UMaine and Mount Desert Island Biological Laboratory (MDIBL) will address cell-microenvironmental signaling across three contexts : mechanisms of viral infection in cultured cells and zebrafish; gradient tracking in yeast, and mechanisms of muscle homeostasis in zebrafish. The five research projects are: Cellular reprogramming in Persistent versus Lytic JC Viral Infections (Maginnis); Motility and Guidance Signals Control Migration of Muscle Precursors (Talbot); Mechanisms of GPCR-induced Autophagy (Kelley); Apelin Signaling in Muscle Regeneration (Madeleine), and Innate Immune Function in Influenza-Associated Myopathy (King). Each project leverages the unique expertise of research project leaders while advancing the theme of extracellular impacts on cell behavior. Projects exploit existing IDeA resources and the proposed new core facility in Microscopy and Image Analysis. This COBRE further enhances partnerships among biomedical research institutions in Maine. As director of a state-wide graduate program with 54 graduate students and >150 faculty, Dr. Henry has the leadership experience to guide this COBRE. This COBRE will accelerate the careers of our Junior Investigators by adding: external senior scientists as mentors, state-of-the art live imaging, image analytics, and an expanded zebrafish facility to strengthen the biomedical research infrastructure. UMaine is the only institution in the state that grants doctoral degrees in biomedical science and biomedical engineering. This COBRE, which will be UMaine’s first, will transform UMaine’s ability to serve as the academic leader for biomedical research in Maine and feed the growing biomedical research industry in Maine. This research will elucidate basic biological mechanisms underlying cell behavior, and also has the potential to inform future treatment of infectious diseases, neuromuscular disorders, and muscle aging and regeneration.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,166,759 )
2025	2025	UNIVERSITY OF MAINE SYSTEM	5717 CORBETT HALL	ORONO	ME	04469	PENOBSCOT	USA	Biomedical Research and Research Training	001	3	5/26/2025	NON-COMPETING CONTINUATION	$2,166,759
2025	2024	UNIVERSITY OF MAINE SYSTEM	5717 CORBETT HALL	ORONO	ME	04469	PENOBSCOT	USA	Biomedical Research and Research Training	000	2	11/26/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,166,759

Issue Date FY: 2024 ( Subtotal = $2,169,489 )
2024	2024	UNIVERSITY OF MAINE SYSTEM	5717 CORBETT HALL	ORONO	ME	04469	PENOBSCOT	USA	Biomedical Research and Research Training	000	2	4/26/2024	NON-COMPETING CONTINUATION	$2,169,489
														Subtotal = $2,169,489

Issue Date FY: 2023 ( Subtotal = $3,049,123 )
2023	2023	UNIVERSITY OF MAINE SYSTEM	5717 CORBETT HALL RM 422	ORONO	ME	04469	PENOBSCOT	USA	Biomedical Research and Research Training	000	1	4/5/2023	NEW	$2,461,149
2023	2023	UNIVERSITY OF MAINE SYSTEM	5717 CORBETT HALL RM 422	ORONO	ME	04469	PENOBSCOT	USA	Biomedical Research and Research Training	001	1	9/8/2023	SUPPLEMENT FOR EXPANSION	$587,974
														Subtotal = $3,049,123

Grand Total All Awards = $7,385,371

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Regulation of Cellular Behavior in Response to Extracellular Cues

Award Number: P20GM144265

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/05/2023

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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