Wednesday, July 30, 2025 7/30/2025

Delaware Center for Musculoskeletal Research

Award Number: P20GM139760
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/15/2021
PERIOD OF PERFORMANCE END DATE: 01/31/2026

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Delaware Center for Musculoskeletal Research - PROJECT SUMMARY/ABSTRACT The musculoskeletal system has both mechanical and biological functions—it generates, transmits, and supports forces, and it regulates organ-level homeostasis and whole-body metabolism. The mechanics and biology of the musculoskeletal system are inextricably intertwined and long-ranging, where mechanical cues, molecular signals, and cell interactions affect each other across multiple scales, from the body, to organ, tissue, cell, and molecule levels. Progress in musculoskeletal research depends on addressing the mechanics and biology of adjacent organs, and evaluating the effects of injury as well as aging. Identifying the mechanisms underlying musculoskeletal health and musculoskeletal disorders (e.g., osteoarthritis, osteoporosis, muscle wasting, post-traumatic repair, degeneration) therefore requires a research paradigm that addresses the synergies within the musculoskeletal system and combines both mechanical and biological approaches across multiple scales. The Delaware Center for Musculoskeletal Research (DCMR) will support basic and preclinical research on the central theme of musculoskeletal health—from the level of the entire body to the actions of key cells and molecules—with emphasis on understanding the mechanisms by which physical and biological cues influence tissue structure and normal function and dysfunction, and identifying potential therapeutic interventions. The proposed DCMR will: Aim 1: Accelerate fundamental musculoskeletal research by supporting synergistic and multidisciplinary Research Projects. Aim 2: Galvanize capabilities for musculoskeletal research by establishing a Multiscale Assessments Research Core. Aim 3: Amplify the impact of musculoskeletal research through faculty mentoring, expansion, and retention. Completion of this 5-year Phase I COBRE will build cross-cutting and synergistic research collaborations across multi-scale and multidisciplinary Research Projects and establish a state-of-the-art Research Core. The DCMR, which will focus on fundamental discovery and preclinical research, will complement the outstanding translational and clinical musculoskeletal research programs at Delaware, creating a comprehensive basic-to- clinical research pipeline at UD. Through fostering cross-cutting and convergent research partnerships, the DCMR aims to substantially reduce the burden of musculoskeletal disorders and improve musculoskeletal health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,397,368 )
2025	2025	UNIVERSITY OF DELAWARE	550 S COLLEGE AVE	NEWARK	DE	19713	NEW CASTLE	USA	Biomedical Research and Research Training	000	5	5/21/2025	NON-COMPETING CONTINUATION	$2,397,368
														Subtotal = $2,397,368

Issue Date FY: 2024 ( Subtotal = $3,461,759 )
2024	2024	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	004	4	8/26/2024	NON-COMPETING CONTINUATION	$0
2024	2024	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	005	4	9/11/2024	SUPPLEMENT FOR EXPANSION	$311,051
2024	2024	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	001	4	4/29/2024	SUPPLEMENT FOR EXPANSION	$250,000
2024	2024	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	003	4	6/17/2024	SUPPLEMENT FOR EXPANSION	$502,654
2024	2024	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	002	4	5/20/2024	NON-COMPETING CONTINUATION	$239,804
2024	2024	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	4	2/5/2024	NON-COMPETING CONTINUATION	$2,158,250
														Subtotal = $3,461,759

Issue Date FY: 2023 ( Subtotal = $3,525,889 )
2023	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	003	3	3/30/2023	NON-COMPETING CONTINUATION	$0
2023	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	004	3	5/22/2023	SUPPLEMENT FOR EXPANSION	$306,774
2023	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	001	3	1/24/2023	NON-COMPETING CONTINUATION	$2,116,893
2023	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	006	3	9/14/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	005	3	9/8/2023	SUPPLEMENT FOR EXPANSION	$867,011
2023	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	002	3	2/16/2023	NON-COMPETING CONTINUATION	$235,211
2023	2022	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	2	11/7/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,525,889

Issue Date FY: 2022 ( Subtotal = $2,611,948 )
2022	2022	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	002	2	5/10/2022	NON-COMPETING CONTINUATION	$236,277
2022	2022	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	003	2	6/20/2022	SUPPLEMENT FOR EXPANSION	$249,183
2022	2022	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	001	2	2/9/2022	NON-COMPETING CONTINUATION	$2,126,488
2022	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	1	11/16/2021	NEW	$0
														Subtotal = $2,611,948

Issue Date FY: 2021 ( Subtotal = $2,350,090 )
2021	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	1	2/14/2021	NEW	$2,350,090
														Subtotal = $2,350,090

Grand Total All Awards = $14,347,054

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Delaware Center for Musculoskeletal Research

Award Number: P20GM139760

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/15/2021

PERIOD OF PERFORMANCE END DATE: 01/31/2026

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