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Center of Biomedical Research Excellence in Acute Care Research and Rural Disparities

Award Number: P20GM139745
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/10/2021
PERIOD OF PERFORMANCE END DATE: 01/31/2026

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Center of Biomedical Research Excellence in Acute Care Research and Rural Disparities - Acute care research can be defined as investigations into preventive, curative, rehabilitative, or palliative actions that depend on time-sensitive and urgent intervention. Thus, acute care encompasses multiple medical specialties, including critical care services, emergency and urgent care, trauma and acute care surgery, and neurocritical care. In rural states, the need for improvements in acute care and acute care research are pressing, as medical advances have increased the disparities between urban and rural areas. These disparities are due in large part to imbalances in access to specialty-trained clinicians, resources and facilities, as well as clinical research. We propose a new inter-departmental Center for Biomedical Research Excellence (COBRE) at Maine Medical Center, a tertiary care center located in the largest population center (Portland) in the state of Maine. Serving as the hub of activities, this program will mentor cohorts of acute care researchers in significant clinical/translational areas of need while providing a foundation for these studies to impact communities and patients in all regions of our state. This COBRE is led by Douglas Sawyer MD, PhD, an established leader in clinical care services, mentorship, and translational research. The aims of this program are: 1) Provide the leadership, governance, and advisory network to establish a COBRE in Acute Care Research and Rural Disparities at Maine Medical Center; 2) Provide project and mentorship support to launch the careers of promising clinician-scientists within this scientific program, and help ensure their long-term scientific success as independent researchers; 3) Enhance the capabilities of Maine Medical Center's core facilities and research infrastructure to support human subject research of both our COBRE investigators and other institutional and external researchers, and to stimulate innovative research methodologies and new collaborations, and 4) Enhance our existing COBRE- and CTR-supported pilot project programs to focus on translational and clinical opportunities related to acute care and rural health disparities. In Phase I, we have initially selected 4 clinical/translational project leaders with clinical research areas of primary need. These include: Teresa May DO, a critical care physician-researcher developing a standardized statewide system of cardiac arrest post-resuscitation care, David Gagnon PharmD, a pharmacist-researcher testing the benefits of prophylactic antibiotics in cardiac arrest survivors, David Seder MD, a critical care physician-researcher expanding his clinical research program to include translational molecular signaling studies of inflammation in cardiac arrest, and Alexa Craig MD, a pediatric neurologist engaged in research utilizing telemedicine to improve survival and neurological outcomes for newborns born at risk for encephalopathy. These researchers will be supported by a robust mentorship and advisory network and a Community Engagement, Bioethics, and Outreach Core that will develop state-wide health professional and community partnerships in a learning healthcare system to enhance understanding of and increase inclusion in human subjects research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,579,993 )
2025	2025	MAINEHEALTH	110 FREE ST	PORTLAND	ME	04101	CUMBERLAND	USA	Biomedical Research and Research Training	001	5	5/28/2025	NON-COMPETING CONTINUATION	$2,579,993
2025	2024	MAINEHEALTH	110 FREE ST	PORTLAND	ME	04101	CUMBERLAND	USA	Biomedical Research and Research Training	000	4	10/30/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,579,993

Issue Date FY: 2024 ( Subtotal = $3,104,129 )
2024	2024	MAINEHEALTH	110 FREE ST	PORTLAND	ME	04101	CUMBERLAND	USA	Biomedical Research and Research Training	005	4	8/1/2024	NON-COMPETING CONTINUATION	$0
2024	2024	MAINEHEALTH	110 FREE ST	PORTLAND	ME	04101	CUMBERLAND	USA	Biomedical Research and Research Training	003	4	5/23/2024	NON-COMPETING CONTINUATION	$257,999
2024	2024	MAINEHEALTH	110 FREE ST	PORTLAND	ME	04101	CUMBERLAND	USA	Biomedical Research and Research Training	001	4	2/7/2024	NON-COMPETING CONTINUATION	$2,321,994
2024	2024	MAINEHEALTH	110 FREE ST	PORTLAND	ME	04101	CUMBERLAND	USA	Biomedical Research and Research Training	006	4	9/11/2024	SUPPLEMENT FOR EXPANSION	$426,281
2024	2024	MAINEHEALTH	110 FREE ST	PORTLAND	ME	04101	CUMBERLAND	USA	Biomedical Research and Research Training	002	4	3/14/2024	NON-COMPETING CONTINUATION	$0
2024	2024	MAINEHEALTH	110 FREE ST	PORTLAND	ME	04101	CUMBERLAND	USA	Biomedical Research and Research Training	004	4	5/23/2024	SUPPLEMENT FOR EXPANSION	$97,855
2024	2023	MAINEHEALTH	110 FREE ST	PORTLAND	ME	04101	CUMBERLAND	USA	Biomedical Research and Research Training	000	3	1/8/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $3,104,129

Issue Date FY: 2023 ( Subtotal = $3,082,380 )
2023	2023	MAINEHEALTH	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	002	3	8/28/2023	SUPPLEMENT FOR EXPANSION	$526,550
2023	2023	MAINEHEALTH	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	001	3	2/15/2023	NON-COMPETING CONTINUATION	$2,555,830
2023	2022	MAINEHEALTH	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	000	2	10/20/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,082,380

Issue Date FY: 2022 ( Subtotal = $2,555,861 )
2022	2022	MAINEHEALTH	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	000	2	1/31/2022	NON-COMPETING CONTINUATION	$2,300,274
2022	2022	MAINEHEALTH	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	001	2	5/20/2022	NON-COMPETING CONTINUATION	$255,587
														Subtotal = $2,555,861

Issue Date FY: 2021 ( Subtotal = $2,596,949 )
2021	2021	MAINEHEALTH	22 BRAMHALL ST	PORTLAND	ME	04102	CUMBERLAND	USA	Biomedical Research and Research Training	000	1	2/10/2021	NEW	$2,596,949
														Subtotal = $2,596,949

Grand Total All Awards = $13,919,312

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Center of Biomedical Research Excellence in Acute Care Research and Rural Disparities

Award Number: P20GM139745

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/10/2021

PERIOD OF PERFORMANCE END DATE: 01/31/2026

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