Tuesday, July 1, 2025 7/1/2025

BioSystems Networks and Translational Research - Insights into Inflammation (BioSNTR-II)

Award Number: P20GM135008
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/20/2022
PERIOD OF PERFORMANCE END DATE: 01/31/2027

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BioSystems Networks and Translational Research - Insights into Inflammation (BioSNTR-II) - PROJECT SUMMARY – OVERALL The goal of this proposal is a coordinated, synergized, and integrated COBRE research program, called the “BioSystems Networks and Translational Research – Insights into Inflammation (BioSNTR-II),” at South Dakota State University (SDSU), Brookings, SD. Our research objective is to improve human health by advancing the understanding of molecular, cellular and tissue-level mechanisms of inflammation research via multi-disciplinary approaches. The overarching hypothesis is that intracellular regulatory events are governed by cell-cell communication across the macrophage, stromal and lymphatic axes during the inflammatory response and its resolution. Junior research project leaders, mentored by senior faculty, define the three research projects of BioSNTR-II in the areas of: macrophage cell biology in inflammation, the role or primary cilia in regulating lymphangiogenesis in inflammation and regulation of tumor necrosis factor signaling and cell death pathways. These projects will be supported by two cutting-edge research cores in (1) transcriptome sequencing, analysis and model development (Transcriptome and Network Analyses Core) and (2) CRISPR- based gene editing and Integrated Microscopy and Gene Evaluation (CRISPR-IMAGE). In addition, an Administrative Core is proposed to support the fiscal and personnel management, implementation, oversight and evaluation of both the research projects and the cores. The synergy and integration of these components has been carefully planned to maximize impact while supporting training, professional development, and the career potential of a cadre of bright, promising basic researchers. The Center will achieve success through the following aims: (1) Develop and manage a thriving environment for inflammation research at SDSU, (2) Establish new Research Cores to expand and enhance biomedical research at SDSU, and (3) Guide center performance and sustainability with assessment and advisory board input.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,966,320 )
2025	2025	SOUTH DAKOTA STATE UNIVERSITY	940 ADMINISTRATION LN	BROOKINGS	SD	57007	BROOKINGS	USA	Biomedical Research and Research Training	000	4	6/16/2025	NON-COMPETING CONTINUATION	$1,966,320
														Subtotal = $1,966,320

Issue Date FY: 2024 ( Subtotal = $2,217,288 )
2024	2024	SOUTH DAKOTA STATE UNIVERSITY	940 ADMINISTRATION LN	BROOKINGS	SD	57007	BROOKINGS	USA	Biomedical Research and Research Training	000	3	2/14/2024	NON-COMPETING CONTINUATION	$1,995,559
2024	2024	SOUTH DAKOTA STATE UNIVERSITY	940 ADMINISTRATION LN	BROOKINGS	SD	57007	BROOKINGS	USA	Biomedical Research and Research Training	001	3	7/16/2024	NON-COMPETING CONTINUATION	$221,729
														Subtotal = $2,217,288

Issue Date FY: 2023 ( Subtotal = $2,384,430 )
2023	2023	SOUTH DAKOTA STATE UNIVERSITY	940 ADMINISTRATION LN	BROOKINGS	SD	57007	BROOKINGS	USA	Biomedical Research and Research Training	003	2	9/7/2023	SUPPLEMENT FOR EXPANSION	$199,811
2023	2023	SOUTH DAKOTA STATE UNIVERSITY	2201 ADMINISTRATION LANE	BROOKINGS	SD	57007	BROOKINGS	USA	Biomedical Research and Research Training	002	2	6/26/2023	NON-COMPETING CONTINUATION	$0
2023	2023	SOUTH DAKOTA STATE UNIVERSITY	2201 ADMINISTRATION LANE	BROOKINGS	SD	57007	BROOKINGS	USA	Biomedical Research and Research Training	000	2	1/31/2023	NON-COMPETING CONTINUATION	$1,966,159
2023	2023	SOUTH DAKOTA STATE UNIVERSITY	2201 ADMINISTRATION LANE	BROOKINGS	SD	57007	BROOKINGS	USA	Biomedical Research and Research Training	001	2	2/15/2023	NON-COMPETING CONTINUATION	$218,460
														Subtotal = $2,384,430

Issue Date FY: 2022 ( Subtotal = $2,459,352 )
2022	2022	SOUTH DAKOTA STATE UNIVERSITY	2201 ADMINISTRATION LANE	BROOKINGS	SD	57007	BROOKINGS	USA	Biomedical Research and Research Training	000	1	3/16/2022	NEW	$2,459,352
														Subtotal = $2,459,352

Grand Total All Awards = $9,027,390

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BioSystems Networks and Translational Research - Insights into Inflammation (BioSNTR-II)

Award Number: P20GM135008

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/20/2022

PERIOD OF PERFORMANCE END DATE: 01/31/2027

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