Thursday, April 24, 2025
4/24/2025
Center for Applied Immunology and Pathological Processes - PROJECT SUMMARY/ABSTRACT A properly functioning and effective immune system is needed to control infection by bacterial, viral and other pathogen invaders, growth of aberrant cells, as well as for proper embryonic development, wound healing, bone remodeling, and other normal homeostatic processes. Thus, understanding the innate and adaptive immune responses and how abnormalities affect human health in chronic inflammatory conditions, during neonatal development and how infectious diseases and cancers subvert or alter these responses is critical to improving our health, not only in the United States, but globally. Closer to home, this unfortunately remains especially true in the state of Louisiana, which ranks near the bottom in many national health studies. For example, human immunodeficiency virus (HIV) age adjusted deaths in the state are more than double the national average, while the state ranks in the top 5 in infections with the sexually transmitted diseases, Syphilis, Gonorrhea and Chlamydia. In addition, as is documented for many states in the south, Louisiana has some of the highest rates of arthritis (affecting ~1 in 4 adults in the state), heart disease and cardiovascular deaths (ranked 46/50 and 48/50 respectively), and cancer-related mortality rates (15-20% higher than the national average) in the nation. These glaring statistics support the need for additional understanding of the pathogenesis of these diseases and new options for therapeutic interventions. One common theme among these different diseases is an aberrant immune response and resulting immunopathologies. Thus, we propose a better understanding of how aberrations in the immune system result in disease is needed. We propose that a targeted growth of an immunology-centric center on our campus at LSUHSC-S will positively influence the health of our citizens. This is especially true as new research shows targeted modifications of the immune response or immunotherapy holds great promise as an effective treatment option to control and eradicate various tumors, for the treatment and mitigation of antibiotic or antiviral resistant infectious diseases, and for the prevention of chronic inflammatory diseases, etc. Diverse research into aspects of immunology, host pathogen interactions, and the immunopathology associated with an abnormal immune response is an important priority at LSU Health Sciences Center Shreveport (LSUHSC-S) within multiple centers and departments. Immunology as a discipline can effectively bridge many centers and departments currently on campus and thus serve as a nucleus for collaborative and synergistic research across diverse disciplines. Immunology as a discipline is now at the forefront of novel therapies to control bacterial infections, viral infections, to treat cancer; thus an expansion and growth of this area at LSUHSC-S will advance the mission of the school to grow basic science that has strong translational potential. The objective of this new COBRE Center for Applied Immunology and Pathological Processes (CAIPP) to establish an independent internationally recognized research and training program at LSUHSC-S. We propose to first mentor and develop federally funded junior faculty research and to develop new infrastructure to support the growth and continued hiring in this important area of biomedical science. Because Dr. Yurochko has 35 years of experience in immunology research, has been a junior PI in a COBRE center, Project Mentor for successful projects and part of a COBRE leadership team, he can draw on a wealth of experiences, along with those of the experienced leadership team, to drive the success of the CAIPP. Second, we propose long term to retain these immunology researchers as they become more senior through promotion, to become an international recognized research hub and to elevate the CAIPP within LSUHSC-S by becoming a state recognized Center. We shall take advantage of the strengths currently on campus and thr
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