Monday, June 30, 2025 6/30/2025

Center for Lung Biology and Disease

Award Number: P20GM130555
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/02/2019
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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Center for Lung Biology and Disease - SUMMARY The Center for Lung Biology and Disease was established through a Phase I Centers of Biomedical Research Excellence (COBRE) award. Our Phase I proposal, aimed at providing Promising Junior Investigators (PJIs) an environment that maximizes their potential to contribute to advances in pulmonary disease research, launched 6 new scientists in independent research careers funded through 11 R-, 1F- and 1K-series NIH grants. This Phase II proposal will expand the tremendously successful programs established in Phase I, with an overarching goal of promoting research to unravel life- threatening respiratory diseases. Its thematic focus encompasses mechanistic studies of host responses to infectious and non-infectious stimuli. The leadership and mentoring teams are highly interactive and our four new PJIs are a dynamic group. In aim 1 of our strategy to launch these PJIs as independent researchers, we will maintain and expand an administrative structure that supports and fosters PJI progress toward scientific independence. This will be accomplished by coordinating activities of the individual projects and cores and fostering their collaborative engagement. We will also provide career and professional resources that together with a team of mentors with strong experience in NIH-funded lung biology, will foster PJI growth toward independent funding. In aim 2, we will enhance the research infrastructure at the LSU School of Veterinary Medicine and provide cutting-edge technologies for enhancing the competitiveness of our PJIs. Through partial funding from our Phase I award, we renovated and expanded our Animal Biosafety Level-2 (ABSL-2) footprint, and in this proposal, we will use institutional support to renovate and increase the footprint of our ABSL-3 facility 2-3-fold. Given the landscape of junior investigator research within our LSU Vet Med environment, where lung biology research emphasizes diseases induced by both infectious diseases and inhalation exposures, we have realized the need for providing one new resource – the Inhalation and Infection Core. The new core will assist investigators with animal infection and delivery of inhaled pollutants and/or therapeutic agents to support their mechanistic studies of respiratory diseases induced through both infectious and non-infectious stimuli. Finally, in aim 3, we will navigate pathways for sustained Center funding supported through the NIH P01 grant program, with the ultimate goal of positioning our growing depth of lung biology expertise to develop a Center of Excellence. The team assembled here has exceptional expertise in lung biology, outstanding leadership and mentoring experience, and a demonstrated history of productive collaboration. This COBRE program will provide novel insights into the pathogenesis of devastating lung diseases to guide improved strategies for treating and preventing these diseases in human populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	001	6	1/27/2025	COMPETING CONTINUATION	$577,719
2025	2023	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	000	5	1/27/2025	NON-COMPETING CONTINUATION	-$577,719
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $2,178,191 )
2024	2024	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	002	6	6/13/2024	COMPETING CONTINUATION	$2,178,191
2024	2024	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	003	6	9/19/2024	COMPETING CONTINUATION	$0
2024	2023	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	000	5	3/26/2024	NON-COMPETING CONTINUATION	$0
2024	2023	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	001	5	6/12/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,178,191

Issue Date FY: 2023 ( Subtotal = $2,235,991 )
2023	2023	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	002	5	2/15/2023	NON-COMPETING CONTINUATION	$223,599
2023	2023	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	001	5	1/18/2023	NON-COMPETING CONTINUATION	$2,012,392
2023	2023	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	003	5	5/5/2023	NON-COMPETING CONTINUATION	$0
2023	2022	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	000	4	10/18/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,235,991

Issue Date FY: 2022 ( Subtotal = $1,886,626 )
2022	2022	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	003	4	9/23/2022	NON-COMPETING CONTINUATION	$499,503
2022	2022	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	001	4	3/8/2022	NON-COMPETING CONTINUATION	$1,163,631
2022	2022	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	002	4	7/6/2022	NON-COMPETING CONTINUATION	$223,492
2022	2021	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	000	3	11/30/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,886,626

Issue Date FY: 2021 ( Subtotal = $2,246,019 )
2021	2021	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	000	3	2/4/2021	NON-COMPETING CONTINUATION	$2,246,019
2021	2021	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	001	3	6/24/2021	NON-COMPETING CONTINUATION	$0
2021	2021	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	002	3	9/2/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,246,019

Issue Date FY: 2020 ( Subtotal = $2,251,189 )
2020	2020	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	002	2	8/1/2020	NON-COMPETING CONTINUATION	$0
2020	2020	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	001	2	2/21/2020	NON-COMPETING CONTINUATION	$225,119
2020	2020	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	000	2	12/31/2019	NON-COMPETING CONTINUATION	$2,026,070
														Subtotal = $2,251,189

Issue Date FY: 2019 ( Subtotal = $2,562,231 )
2019	2019	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	001	1	9/17/2019	NEW	$0
2019	2019	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Biomedical Research and Research Training	000	1	1/2/2019	NEW	$2,562,231
														Subtotal = $2,562,231

Grand Total All Awards = $13,360,247

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Center for Lung Biology and Disease

Award Number: P20GM130555

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/02/2019

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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