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Center for Quantitative Biology: A focus on "omics", from organisms to single cells

Award Number: P20GM130454
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2019
PERIOD OF PERFORMANCE END DATE: 06/30/2029

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Center for Quantitative Biology: A focus on "omics", from organisms to single cells - Center for Quantitative Biology: A focus on omics , from organisms to single cells PROJECT SUMMARY High-throughput single-cell, spatial, and immune-cell -omic profiling technologies provide a wealth of data to interrogate basic biological processes, changes in cellular processes, and the molecular basis of disease. When combined with genomic data science, these fields are opening new frontiers in biology. Phase 1 established the Center for Quantitative Biology (CQB) with the goal to support and enhance NIH-funded quantitative biological research at Dartmouth and to facilitate integration of single-cell -omic technologies with cutting-edge computational methods. The success of the CQB in Phase 1 is highlighted by the graduation of four Research Project Leaders (RPLs), the onboarding of four new RPLs, and the hiring of seven new tenure-track faculty in CQB focus areas. The IDeA program investment in CQB RPLs and research cores returned >$60 million in total external funding, leveraging NIH funds 5:1. Phase 2 will build on the successes of Phase 1 by mentoring the next generation of CQB COBRE RPLs, continuing growth of research cores, and enabling scientists to engage in cutting-edge scientific inquiry. The CQB will continue to draw upon faculty from Dartmouth’s Geisel School of Medicine, the Thayer School of Engineering, Arts & Sciences, and Dartmouth Health. Through its emphasis on next-generation data, the CQB will synergize genomic data science with ongoing experimental genomic initiatives across campus, a goal accomplished via four specific areas: 1) Enhance the research competitiveness of junior faculty in genomic data science and experimental genomics by providing a research environment that supports and enhances their projects. 2) Expand the breadth and impact of research from NIH-funded quantitative biologists at Dartmouth by: (a) continuing to recruit talented quantitative biology faculty; (b) mentoring junior quantitative biologists; and (c) providing systems for translating single-cell dynamics to applications in human disease. 3) Develop, maintain, and leverage key shared resources to support faculty in the CQB, at Dartmouth, and in the IDeA community by growing the Single-Cell Genomics and Genomic Data Science Cores. 4) Create synergistic interactions between the dry-lab computational scientist and traditional experimental scientist to promote cross-talk, collaboration, and integrative analyses between the disciplines. Dartmouth continues to make a substantial institutional commitment to the success and long-term sustainability of the CQB, including the commitment to hiring five new tenure-track faculty. Institutional program enrichment funds will support research infrastructure, scientific exchange, and a pilot project program to foster a vibrant intellectual community, recruit new project leaders, and enhance the impact and funding competitiveness of all CQB members. With experienced leadership, efficient administrative structures, and a compelling vision, CQB has demonstrated a paradigm that interweaves computational and experimental early-stage translational research, allowing the CQB to grow its portfolio of extramurally-funded investigators and thrive as a nationally- recognized Center of Biomedical Research Excellence.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	004	6	1/23/2025	COMPETING CONTINUATION	$0
2025	2024	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	001	6	11/21/2024	COMPETING CONTINUATION	$946,470
2025	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	002	5	11/21/2024	SUPPLEMENT FOR EXPANSION	-$319,479
2025	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	000	5	11/21/2024	NON-COMPETING CONTINUATION	-$476,601
2025	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	003	5	11/21/2024	SUPPLEMENT FOR EXPANSION	-$150,390
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $3,871,999 )
2024	2024	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	004	6	7/23/2024	SUPPLEMENT FOR EXPANSION	$328,000
2024	2024	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	002	6	6/6/2024	COMPETING CONTINUATION	$2,461,600
2024	2024	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	003	6	7/19/2024	SUPPLEMENT FOR EXPANSION	$1,082,397
2024	2024	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	005	6	8/21/2024	COMPETING CONTINUATION	$0
2024	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	000	5	11/14/2023	NON-COMPETING CONTINUATION	$0
2024	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	001	5	1/11/2024	NON-COMPETING CONTINUATION	$2
														Subtotal = $3,871,999

Issue Date FY: 2023 ( Subtotal = $4,853,929 )
2023	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	003	5	8/23/2023	NON-COMPETING CONTINUATION	$2,444,226
2023	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	006	5	9/11/2023	SUPPLEMENT FOR EXPANSION	$245,250
2023	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	004	5	8/29/2023	NON-COMPETING CONTINUATION	$0
2023	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	007	5	9/18/2023	SUPPLEMENT FOR EXPANSION	$1,393,183
2023	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	005	5	8/29/2023	SUPPLEMENT FOR EXPANSION	$771,270
2023	2022	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	000	4	12/16/2022	NON-COMPETING CONTINUATION	$0
2023	2022	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	002	4	7/19/2023	NON-COMPETING CONTINUATION	$0
2023	2022	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	001	4	1/19/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,853,929

Issue Date FY: 2022 ( Subtotal = $2,694,226 )
2022	2022	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	004	4	8/8/2022	SUPPLEMENT FOR EXPANSION	$250,000
2022	2022	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	006	4	9/21/2022	NON-COMPETING CONTINUATION	$0
2022	2022	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	003	4	7/11/2022	NON-COMPETING CONTINUATION	$2,444,226
2022	2022	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	005	4	8/30/2022	NON-COMPETING CONTINUATION	$0
2022	2021	TRUSTEES OF DARTMOUTH COLLEGE	6001 PARKHURST HALL STE 207	HANOVER	NH	03755	GRAFTON	USA	Cancer Treatment Research	001	3	1/19/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	TRUSTEES OF DARTMOUTH COLLEGE	6001 PARKHURST HALL STE 207	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	000	3	11/1/2021	NON-COMPETING CONTINUATION	$0
2022	2021	TRUSTEES OF DARTMOUTH COLLEGE	6001 PARKHURST HALL STE 207	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	002	3	4/26/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,694,226

Issue Date FY: 2021 ( Subtotal = $3,256,808 )
2021	2021	TRUSTEES OF DARTMOUTH COLLEGE	6001 PARKHURST HALL STE 207	HANOVER	NH	03755	GRAFTON	USA	Cancer Treatment Research	003	3	6/28/2021	SUPPLEMENT FOR EXPANSION	$812,582
2021	2021	TRUSTEES OF DARTMOUTH COLLEGE	6001 PARKHURST HALL STE 207	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	002	3	6/17/2021	NON-COMPETING CONTINUATION	$2,444,226
2021	2021	TRUSTEES OF DARTMOUTH COLLEGE	6001 PARKHURST HALL STE 207	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	004	3	7/22/2021	NON-COMPETING CONTINUATION	$0
2021	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	001	2	3/29/2021	NON-COMPETING CONTINUATION	$0
2021	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	000	2	12/15/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,256,808

Issue Date FY: 2020 ( Subtotal = $2,444,226 )
2020	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	001	2	7/7/2020	NON-COMPETING CONTINUATION	$2,444,226
2020	2019	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	000	1	12/10/2019	NEW	$0
														Subtotal = $2,444,226

Issue Date FY: 2019 ( Subtotal = $2,760,226 )
2019	2019	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	000	1	7/30/2019	NEW	$2,760,226
														Subtotal = $2,760,226

Grand Total All Awards = $19,881,414

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Center for Quantitative Biology: A focus on "omics", from organisms to single cells

Award Number: P20GM130454

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2019

PERIOD OF PERFORMANCE END DATE: 06/30/2029

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