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Center for Addiction and Disease Risk Exacerbation

Award Number: P20GM130414
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2019
PERIOD OF PERFORMANCE END DATE: 07/31/2029

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Center for Addiction and Disease Risk Exacerbation - Substance use (SU) negatively affects the risk, management, progression, and outcomes of chronic disease and contributes to socioeconomic and racial/ethnic health disparities. Although linkages between SU and chronic disease are well documented, biopsychosocial mechanisms underlying these linkages are poorly understood. Prospective, longitudinal studies that investigate links between SU and chronic disease are needed to inform the development of targeted prevention and intervention efforts. In Phase I, the Center for Addiction and Disease Risk Exacerbation (CADRE) made considerable progress toward establishing a multidisciplinary research center of excellence. With support from our Administrative and Clinical Laboratory Cores, we provided 11 early-stage investigators (ESI) with research funding and career development to support their transition to research independence. Our CADRE team published 612 peer-reviewed articles, 147 of which were directly CADRE-supported, and 4 (of 6) of our initial cohort of Project Leaders (PL) obtained R01s. In Phase II of the CADRE, we propose to continue to support ESIs leading thematically and technically linked studies. Our three initial Phase II PLs will (1) examine effects of alternative nicotine delivery products on smoking, obesity, and relevant clinical outcomes among people with obesity who smoke (Murphy); (2) investigate how sleep and negative affect may mediate the short-and long-term relationship between cannabis use and depression in young adults (Sokolovsky); and (3) investigate the intergenerational effects of parental alcohol use on child externalizing disorders, a predictor of health problems over the life course (Micalizzi). CADRE PLs and Pilot Project Leaders (PPLs) will benefit from mentorship by faculty mentors who will provide guidance on research, publication, and grant writing. The Administrative Core will continue to provide organizational structure and state-of-the-art mentoring; administer the Pilot Projects Program; and lead evaluation of all RPs and center components. The Clinical Laboratory Core will continue to provide research infrastructure and resources to the PLs and PPLs, thereby enhancing investigator productivity and promoting research rigor and reproducibility. Our Recruitment, Engagement, and Community Health (REACH) Core will provide direct support for local, face-to-face and digital recruitment, to help CADRE ESIs meet their enrollment and inclusion goals. Through innovative and interdisciplinary research, the CADRE will contribute new knowledge and continue to serve as the nexus and path toward independence for the next generation of scientists.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,327,721 )
2025	2025	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	005	7	8/13/2025	NON-COMPETING CONTINUATION	$2,327,721
2025	2024	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	6	10/28/2024	COMPETING CONTINUATION	$0
2025	2024	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	002	6	12/13/2024	COMPETING CONTINUATION	$0
2025	2024	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	001	6	11/8/2024	SUPPLEMENT FOR EXPANSION	$0
2025	2024	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	004	6	1/2/2025	COMPETING CONTINUATION	$1,324,489
2025	2023	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	003	5	1/2/2025	NON-COMPETING CONTINUATION	-$1,324,489
														Subtotal = $2,327,721

Issue Date FY: 2024 ( Subtotal = $3,257,595 )
2024	2024	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	003	6	9/4/2024	SUPPLEMENT FOR EXPANSION	$865,095
2024	2024	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	002	6	8/29/2024	COMPETING CONTINUATION	$2,392,500
2024	2023	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	5	5/31/2024	NON-COMPETING CONTINUATION	$0
2024	2023	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	001	5	8/29/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,257,595

Issue Date FY: 2023 ( Subtotal = $2,232,943 )
2023	2023	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	002	5	8/25/2023	NON-COMPETING CONTINUATION	$2,232,943
2023	2022	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	001	4	6/7/2023	NON-COMPETING CONTINUATION	$0
2023	2022	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	4	4/6/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,232,943

Issue Date FY: 2022 ( Subtotal = $2,430,344 )
2022	2022	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	001	4	7/15/2022	NON-COMPETING CONTINUATION	$1,897,868
2022	2022	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	003	4	9/23/2022	NON-COMPETING CONTINUATION	$203,469
2022	2022	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	002	4	7/26/2022	SUPPLEMENT FOR EXPANSION	$329,007
2022	2021	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	3	6/1/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,430,344

Issue Date FY: 2021 ( Subtotal = $2,239,343 )
2021	2021	BROWN UNIVERSITY	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	001	3	9/15/2021	NON-COMPETING CONTINUATION	$2,239,343
2021	2020	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	2	1/29/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,239,343

Issue Date FY: 2020 ( Subtotal = $2,311,495 )
2020	2020	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	001	2	9/9/2020	NON-COMPETING CONTINUATION	$2,311,495
2020	2019	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	1	12/23/2019	NEW	$0
														Subtotal = $2,311,495

Issue Date FY: 2019 ( Subtotal = $2,711,586 )
2019	2019	BROWN UNIVERSITY IN PROVIDENCE IN THE STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS	1 PROSPECT ST	PROVIDENCE	RI	02912	PROVIDENCE	USA	Biomedical Research and Research Training	000	1	7/26/2019	NEW	$2,711,586
														Subtotal = $2,711,586

Grand Total All Awards = $17,511,027

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Center for Addiction and Disease Risk Exacerbation

Award Number: P20GM130414

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2019

PERIOD OF PERFORMANCE END DATE: 07/31/2029

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