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Center for Translational Research on Aging

Award Number: P20GM125526
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/2019
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Center for Translational Research on Aging - ABSTRACT Kuakini Medical Center (Kuakini) proposes to develop a multidisciplinary Hawai'i-based Center of Biomedical Research Excellence (COBRE) for translational research on aging. This Center will draw on the most promising junior investigators from across the state with cross-institutional and interdisciplinary collaborative efforts between Kuakini, the University of Hawaii John A. Burns School of Medicine (JABSOM), and major academic research centers and medical centers. It will cross institutional borders to promote research aimed at improving human healthy lifespan (healthspan) and ameliorating major age-related diseases, including cardiovascular diseases, cancer and dementia, in people of Hawaii, the U.S. mainland and around the world. The Center will build upon the strengths of Kuakini's five-decade track record of NIH-funded research, its 420,000-specimen biorepository, and its existing strengths in aging research, notably, the 51-year long Kuakini Honolulu Heart Program (Kuakini HHP) and Kuakini Honolulu-Asia Aging Study (Kuakini HAAS), and Kuakini HHP Offspring Study. This will advance translational aging research and foster meaningful solutions toward the disease and disability associated with the aging process. We will pursue this long-term goal via the following specific aims:  Specific Aim 1: Create a world class, innovative, interdisciplinary Center for Translational Research on Aging (CTRA) by building on the existing rare and valuable Kuakini Honolulu Heart Program (Kuakini HHP) and its related studies, existing Kuakini HHP Offspring Study, and research infrastructure.  Specific Aim 2 - Advance the genomic, biological and clinical science of aging, and enhance the world class character of our proposed Center, by enlisting accomplished senior scientists to mentor promising Hawaii-based junior investigators in interdisciplinary research and career development.  Specific Aim 3 - Elevate the capacity of our Center by: i) creating a state-of-the-art Clinical and Translational Core, and ii) collaborating with other Centers of Biomedical Research Excellence. The Clinical and Translational Core will expand upon the strong epidemiologic, genomic and clinical work of Kuakini HHP and related studies and the Kuakini HHP Offspring Study; benefit investigators in the State of Hawaii and abroad, and foster translation of basic science and clinical findings into novel applications and therapeutics for healthy aging. COBRE funding will be leveraged with institutional commitments to accelerate the development of research excellence. The Center will collaborate with three other Hawaii-based COBREs, the COBRE Mouse Phenotyping Core, and the INBRE-funded Bioinformatics and Biostatistics Core at the University of Hawaii.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	KUAKINI MEDICAL CENTER	347 N KUAKINI ST	HONOLULU	HI	96817	HONOLULU	USA	Biomedical Research and Research Training	000	5	2/15/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $2,333,167 )
2023	2023	KUAKINI MEDICAL CENTER	347 N KUAKINI ST	HONOLULU	HI	96817	HONOLULU	USA	Biomedical Research and Research Training	002	5	9/20/2023	NON-COMPETING CONTINUATION	$2,333,167
2023	2022	KUAKINI MEDICAL CENTER	347 N KUAKINI ST	HONOLULU	HI	96817	HONOLULU	USA	Biomedical Research and Research Training	001	4	9/20/2023	NON-COMPETING CONTINUATION	$0
2023	2022	KUAKINI MEDICAL CENTER	347 N KUAKINI ST	HONOLULU	HI	96817	HONOLULU	USA	Biomedical Research and Research Training	000	4	7/13/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,333,167

Issue Date FY: 2022 ( Subtotal = $2,337,602 )
2022	2022	KUAKINI MEDICAL CENTER	347 N KUAKINI ST	HONOLULU	HI	96817	HONOLULU	USA	Biomedical Research and Research Training	001	4	8/25/2022	NON-COMPETING CONTINUATION	$2,337,602
2022	2021	KUAKINI MEDICAL CENTER	347 N KUAKINI ST	HONOLULU	HI	96817	HONOLULU	USA	Biomedical Research and Research Training	000	3	1/21/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,337,602

Issue Date FY: 2021 ( Subtotal = $2,369,627 )
2021	2021	KUAKINI MEDICAL CENTER	347 N KUAKINI ST	HONOLULU	HI	96817	HONOLULU	USA	Biomedical Research and Research Training	000	3	9/23/2021	NON-COMPETING CONTINUATION	$2,369,627
														Subtotal = $2,369,627

Issue Date FY: 2020 ( Subtotal = $2,418,505 )
2020	2020	KUAKINI MEDICAL CENTER	347 N KUAKINI ST	HONOLULU	HI	96817	HONOLULU	USA	Biomedical Research and Research Training	000	2	9/15/2020	NON-COMPETING CONTINUATION	$2,418,505
														Subtotal = $2,418,505

Issue Date FY: 2019 ( Subtotal = $2,500,977 )
2019	2019	KUAKINI MEDICAL CENTER	347 N KUAKINI ST	HONOLULU	HI	96817	HONOLULU	USA	Biomedical Research and Research Training	000	1	9/10/2019	NEW	$2,500,977
														Subtotal = $2,500,977

Grand Total All Awards = $11,959,878

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Center for Translational Research on Aging

Award Number: P20GM125526

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/2019

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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