Monday, June 30, 2025 6/30/2025

Center for Musculoskeletal Disease Research (CMDR)

Award Number: P20GM125503
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/16/2018
PERIOD OF PERFORMANCE END DATE: 01/31/2028

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Center for Musculoskeletal Disease Research (CMDR) - PROJECT SUMMARY/ABSTRACT - OVERALL Conditions such as osteoporosis and osteoarthritis, and malignancies such as breast cancer, negatively affect the musculoskeletal system, leading to substantial disability and health care costs. Thus, there is an ongoing need to better understand the causes of these conditions and to support development of more effective and well-tolerated therapies. The Center for Musculoskeletal Disease Research (CMDR) was established at the University of Arkansas for Medical Sciences (UAMS) during Phase 1 to meet this need. The scientific theme of the CMDR is that identification of molecular contributors to musculoskeletal dysfunction and disease will guide development of effective therapies. To study these conditions, we have assembled teams of junior and established investigators and supported development of junior investigators to the point of achieving independent R01-level funding. We also utilize state-of-the-art technologies to analyze gene expression, genetically manipulate animals, and analyze the skeleton. These complementary approaches, together with access to clinical investigators and patient samples, have synergized to create a unique and productive research environment. A key to the continued success of the Center will be to increase the number of investigators whose research is aligned with our scientific theme via development of more junior investigators and recruitment of new and established investigators. To accomplish this, in Phase 2 we propose to support the development of 3 Project Leaders by providing structured mentoring, financial resources, and collaboration with other CMDR investigators (Aim 1). We will also continue to strengthen the biomedical research infrastructure at UAMS by increasing the capabilities and utilization of 4 research cores that provide access to rapid, high-quality services and that develop new approaches, such as CRISPR interference for in vivo loss-of-function studies (Aim 2). To continue building a critical mass of musculoskeletal investigators and teams, the Center will utilize a Pilot Project Program, targeted recruitment of investigators with complementary expertise, and incorporation of new and established center investigators into synergistic and productive research teams (Aim 3). Successful implementation of this Organization and Management Plan will, in the long-term, lead to a self-sustaining Center of Biomedical Research Excellence that will generate novel and important results leading to more effective therapies for the numerous conditions that involve the musculoskeletal system.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,295,000 )
2025	2025	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	8	6/19/2025	NON-COMPETING CONTINUATION	$2,295,000
														Subtotal = $2,295,000

Issue Date FY: 2024 ( Subtotal = $2,545,000 )
2024	2024	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	005	7	7/16/2024	NON-COMPETING CONTINUATION	$229,499
2024	2024	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	006	7	7/22/2024	SUPPLEMENT FOR EXPANSION	$250,000
2024	2024	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	003	7	2/23/2024	NON-COMPETING CONTINUATION	$2,065,501
2024	2024	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	004	7	3/5/2024	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	002	6	2/6/2024	COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	6	1/11/2024	COMPETING CONTINUATION	$435,014
2024	2022	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	5	1/11/2024	NON-COMPETING CONTINUATION	-$435,014
														Subtotal = $2,545,000

Issue Date FY: 2023 ( Subtotal = $2,295,000 )
2023	2023	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	6	3/24/2023	COMPETING CONTINUATION	$2,295,000
2023	2023	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	003	6	6/8/2023	COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	002	5	3/30/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	5	1/12/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,295,000

Issue Date FY: 2022 ( Subtotal = $2,274,413 )
2022	2022	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	004	5	8/4/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	003	5	5/6/2022	NON-COMPETING CONTINUATION	$227,444
2022	2022	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	002	5	2/15/2022	NON-COMPETING CONTINUATION	$0
2022	2022	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	5	2/9/2022	NON-COMPETING CONTINUATION	$2,046,969
2022	2021	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	4	2/8/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,274,413

Issue Date FY: 2021 ( Subtotal = $2,274,413 )
2021	2021	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	4	2/22/2021	NON-COMPETING CONTINUATION	$2,274,413
2021	2021	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	002	4	9/21/2021	NON-COMPETING CONTINUATION	$0
2021	2020	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	3	1/26/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,274,413

Issue Date FY: 2020 ( Subtotal = $2,268,208 )
2020	2020	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	3	3/2/2020	NON-COMPETING CONTINUATION	$2,268,208
2020	2020	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	002	3	9/24/2020	NON-COMPETING CONTINUATION	$0
2020	2019	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	2	11/7/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,268,208

Issue Date FY: 2019 ( Subtotal = $2,253,315 )
2019	2019	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	003	2	8/16/2019	NON-COMPETING CONTINUATION	$0
2019	2019	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	2	2/13/2019	NON-COMPETING CONTINUATION	$2,253,315
2019	2019	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	2	3/6/2019	NON-COMPETING CONTINUATION	$0
2019	2019	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	004	2	9/10/2019	NON-COMPETING CONTINUATION	$0
2019	2019	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	002	2	7/8/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,253,315

Issue Date FY: 2018 ( Subtotal = $2,238,422 )
2018	2018	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	1	2/16/2018	NEW	$2,238,422
														Subtotal = $2,238,422

Grand Total All Awards = $18,443,771

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Center for Musculoskeletal Disease Research (CMDR)

Award Number: P20GM125503

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/16/2018

PERIOD OF PERFORMANCE END DATE: 01/31/2028

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