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SC COBRE for TranslationalResearch Improving MusculoskeletalHealth (SC-TRIMH)

Award Number: P20GM121342
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2018
PERIOD OF PERFORMANCE END DATE: 07/31/2028

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SC COBRE for TranslationalResearch Improving MusculoskeletalHealth (SC-TRIMH) - SUMMARY The overall goal of the South Carolina COBRE for Translational Research Improving Musculoskeletal Health (SC-TRIMH) is to advance our understanding of musculoskeletal diseases and their management by enhancing and expanding the biomedical research capacity at Clemson University. Phase I SC-TRIMH successfully established and implemented the new scientific paradigm of Virtual Human Trials (VTH) for translational research. Virtual Human Trials consists of powerful computational modeling combined with quantitative functional validation and in vivo assessment to expedite the development of new therapeutics, interventions, and devices for musculoskeletal health. The overarching SC-TRIMH Phase II approach is to continue promoting outstanding multidisciplinary and collaborative research to improve patient care using this new paradigm. SC- TRIMH is a multidisciplinary and interactive center promoting translational research for musculoskeletal health which supports junior investigators and enhances their research competitiveness. The specific aims are to: 1) expand the critical mass of funded investigators conducting musculoskeletal research by implementing the concept of VHT for the development of new devices, interventions, and therapeutics for musculoskeletal disorders; 2) strengthen innovative scientific cores that support and advance musculoskeletal research to provide SC-TRIMH researchers with the best support to move their research forward to patient care; and 3) advance the ongoing development of an independent, sustainable, multidisciplinary thematic program by promoting the planning of program project and center grants at the institution level by building teams of PIs in niche areas, establishing a platform for technology transfer and commercialization through collaborations with Clemson University Research Foundation and the South Carolina Research Authority for academic startups, and develop a strategy for administrative infrastructure and financial recovery for SC-TRIMH resources. The Center is led by a leadership team with multidisciplinary expertise coalescing resources and disciplines from Clemson University School of Health Research (CUSHR) and its clinical partner, PRISMA Health System (PHS). The scientific cores include: 1) Multi-scale Computational Modeling Core providing cluster computing, bioengineering, bioinformatics, and systems biology expertise to model patient/specimen specific musculoskeletal system at body, tissue, and cellular levels for the development of novel technology; 2) Advanced Fabrication and Testing Core to generate, refine, and optimize the function and performance of technology using the advanced micro and macro fabrication technologies; and, 3) Preclinical Assessment Core to provide animal testing and human cadaver analysis to assess the in vivo function of novel devices, interventions, and therapeutics. These cores will support Phase II Research Project Leaders (RPLs) to advance musculoskeletal health and facilitate their competitiveness for national research awards. Extensive institutional support including flexible funds and three new tenure-track faculty positions will contribute to the Center's long-term success and viability.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,217,769 )
2025	2025	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	000	8	9/10/2025	NON-COMPETING CONTINUATION	$2,217,769
														Subtotal = $2,217,769

Issue Date FY: 2024 ( Subtotal = $2,480,379 )
2024	2024	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	005	7	8/26/2024	SUPPLEMENT FOR EXPANSION	$249,632
2024	2024	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	004	7	8/23/2024	NON-COMPETING CONTINUATION	$2,230,747
2024	2023	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	003	6	2/22/2024	COMPETING CONTINUATION	$539,825
2024	2022	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	002	5	2/22/2024	SUPPLEMENT FOR EXPANSION	-$125,554
2024	2022	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	000	5	2/22/2024	NON-COMPETING CONTINUATION	-$372,920
2024	2022	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	001	5	2/22/2024	SUPPLEMENT FOR EXPANSION	-$41,352
														Subtotal = $2,480,379

Issue Date FY: 2023 ( Subtotal = $2,600,749 )
2023	2023	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	000	6	8/23/2023	COMPETING CONTINUATION	$2,255,229
2023	2023	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	002	6	9/15/2023	SUPPLEMENT FOR EXPANSION	$345,520
2023	2022	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	001	5	9/1/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,600,749

Issue Date FY: 2022 ( Subtotal = $3,156,457 )
2022	2022	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	002	5	8/24/2022	NON-COMPETING CONTINUATION	$2,853,488
2022	2022	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	004	5	8/27/2022	SUPPLEMENT FOR EXPANSION	$672,958
2022	2022	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	001	4	7/15/2022	SUPPLEMENT FOR EXPANSION	$61,179
2022	2022	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	005	5	8/30/2022	SUPPLEMENT FOR EXPANSION	$241,790
2022	2022	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	003	5	8/26/2022	NON-COMPETING CONTINUATION	-$672,958
2022	2021	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	000	4	4/5/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,156,457

Issue Date FY: 2021 ( Subtotal = $3,187,550 )
2021	2021	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	002	4	9/16/2021	NON-COMPETING CONTINUATION	$2,814,356
2021	2021	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	001	3	6/7/2021	SUPPLEMENT FOR EXPANSION	$124,952
2021	2021	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	003	4	9/17/2021	SUPPLEMENT FOR EXPANSION	$248,242
2021	2020	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	000	3	3/18/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,187,550

Issue Date FY: 2020 ( Subtotal = $2,199,695 )
2020	2020	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	002	3	8/21/2020	NON-COMPETING CONTINUATION	$2,199,695
2020	2019	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	000	2	2/21/2020	NON-COMPETING CONTINUATION	$0
2020	2019	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	001	2	3/3/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,199,695

Issue Date FY: 2019 ( Subtotal = $2,203,367 )
2019	2019	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	000	2	9/4/2019	NON-COMPETING CONTINUATION	$2,203,367
														Subtotal = $2,203,367

Issue Date FY: 2018 ( Subtotal = $2,223,903 )
2018	2018	CLEMSON UNIVERSITY	201 SIKES HALL	CLEMSON	SC	29634	PICKENS	USA	Biomedical Research and Research Training	000	1	9/15/2018	NEW	$2,223,903
														Subtotal = $2,223,903

Grand Total All Awards = $20,269,869

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SC COBRE for TranslationalResearch Improving MusculoskeletalHealth (SC-TRIMH)

Award Number: P20GM121342

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2018

PERIOD OF PERFORMANCE END DATE: 07/31/2028

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