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The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP)

Award Number: P20GM121312
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2017
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) - PROJECT SUMMARY: Overall Mood and Anxiety Disorders are the most prevalent and disabling mental health conditions worldwide, yet there are limited explanatory and predictive disease models available for these conditions. The theme of the Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) CoBRE is based on the premise that experimental designs that use transdiagnostic approaches (i.e., processes that cut across disease categories) with multiple levels of analyses (symptoms & behavior, circuits & physiology, cells & molecules) can identify disease modifying processes that can become targets of interventions. Phase I of NeuroMAP recruited 8 RPLs and 8 PPIs. As of 6/2022, they applied for 99 extramural grants, received 8 federal grants, and published 130 papers linked to the P20. Two underrepresented minority investigators using NeuroMAP Core data received prestigious Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) K99/R00 awards. Prior to the NeuroMAP CoBRE (funded 9/15/2017) the annual NIH funding for LIBR was $662,104 (NIH Reporter accessed 6/17/2022), for 2021/22 the annual funding is $7,555,510 ($5,368,214 without the CoBRE), which is a 11.4 (8.1)-fold increase. The goal for Phase II of the NeuroMAP is to maintain and expand the infrastructure for RPLs. The Specific Aims of NeuroMAP are: (1) To expand the critical mass of investigators that are focused on Neuroscience-based Mental Health Assessment and Prediction approaches to mood and anxiety disorders. (2) To provide an operational infrastructure that provides the tools necessary to conduct research projects, standardize assessments, and provide a data repository for future pilot projects. (3) To provide a mentoring and career development infrastructure to junior investigators to conduct studies focused on targetable, disease modifying processes in mood or anxiety disorders. NeuroMAP will consists of: (a) an Administrative Core (Paulus); a Recruitment and Assessment Core (Aupperle & Khalsa), a Circuit and Molecules Core (Rohan & Savitz), and a Data Management and Statistics Core (Kuplicki & Thompson). There are three proposed projects: (1) Transcranial Direct Current Stimulation: Threat Sensitivity target (Ironside) - External Mentor: Monique Ernst, NIMH; Internal Mentor: Robin Aupperle, LIBR. (2) The effects of aversive interoceptive states on the computations and associated neural basis of avoidance behavior (Smith) - External Mentor: Philip Corlett, Yale University; Internal Mentor: Jennifer Stewart, LIBR. (3) Modulating repetitive negative thinking related brain networks in young adults with depression (Tsuchiyagaito) - External Mentor: Kate Fitzgerald, University of Michigan; Internal Mentor: Jonathan Savitz, LIBR. The goal of Phase II is to expand research in mood and anxiety disorders, build a bigger base of funded investigators, and to attract more young talent to delineate the processes that contribute to individuals developing, recovering from, and relapsing to mood and anxiety disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $2,479,732 )
2024	2024	LAUREATE INSTITUTE FOR BRAIN RESEARCH, LLC	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Biomedical Research and Research Training	002	7	7/26/2024	NON-COMPETING CONTINUATION	$2,479,732
2024	2023	LAUREATE INSTITUTE FOR BRAIN RESEARCH, LLC	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Biomedical Research and Research Training	001	6	4/1/2024	COMPETING CONTINUATION	$30
2024	2021	LAUREATE INSTITUTE FOR BRAIN RESEARCH, LLC	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Biomedical Research and Research Training	000	5	4/1/2024	NON-COMPETING CONTINUATION	-$30
														Subtotal = $2,479,732

Issue Date FY: 2023 ( Subtotal = $2,512,335 )
2023	2023	LAUREATE INSTITUTE FOR BRAIN RESEARCH	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Biomedical Research and Research Training	000	6	7/27/2023	COMPETING CONTINUATION	$2,512,335
														Subtotal = $2,512,335

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	LAUREATE INSTITUTE FOR BRAIN RESEARCH, INC.	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Biomedical Research and Research Training	000	5	6/13/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $2,187,296 )
2021	2021	LAUREATE INSTITUTE FOR BRAIN RESEARCH, INC.	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Biomedical Research and Research Training	004	5	7/8/2021	NON-COMPETING CONTINUATION	$2,187,296
2021	2020	LAUREATE INSTITUTE FOR BRAIN RESEARCH, INC.	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Biomedical Research and Research Training	002	4	5/10/2021	NON-COMPETING CONTINUATION	$0
2021	2020	LAUREATE INSTITUTE FOR BRAIN RESEARCH, INC.	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Biomedical Research and Research Training	000	4	11/6/2020	NON-COMPETING CONTINUATION	$0
2021	2020	LAUREATE INSTITUTE FOR BRAIN RESEARCH, INC.	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Biomedical Research and Research Training	001	4	4/9/2021	NON-COMPETING CONTINUATION	$0
2021	2020	LAUREATE INSTITUTE FOR BRAIN RESEARCH, INC.	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Biomedical Research and Research Training	003	4	6/22/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,187,296

Issue Date FY: 2020 ( Subtotal = $2,220,447 )
2020	2020	LAUREATE INSTITUTE FOR BRAIN RESEARCH, INC.	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Biomedical Research and Research Training	002	4	8/24/2020	NON-COMPETING CONTINUATION	$2,220,447
2020	2019	LAUREATE INSTITUTE FOR BRAIN RESEARCH, INC.	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Biomedical Research and Research Training	000	3	11/11/2019	NON-COMPETING CONTINUATION	$0
2020	2018	LAUREATE INSTITUTE FOR BRAIN RESEARCH, INC.	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Biomedical Research and Research Training	001	2	11/20/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,220,447

Issue Date FY: 2019 ( Subtotal = $2,270,739 )
2019	2019	LAUREATE INSTITUTE FOR BRAIN RESEARCH, INC.	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Biomedical Research and Research Training	003	3	8/26/2019	NON-COMPETING CONTINUATION	$2,270,739
2019	2018	LAUREATE INSTITUTE FOR BRAIN RESEARCH, INC.	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Biomedical Research and Research Training	000	2	12/31/2018	NON-COMPETING CONTINUATION	$0
2019	2018	LAUREATE INSTITUTE FOR BRAIN RESEARCH, INC.	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Biomedical Research and Research Training	001	2	5/20/2019	NON-COMPETING CONTINUATION	$0
2019	2018	LAUREATE INSTITUTE FOR BRAIN RESEARCH, INC.	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Biomedical Research and Research Training	002	2	6/6/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,270,739

Issue Date FY: 2018 ( Subtotal = $2,308,176 )
2018	2018	LAUREATE INSTITUTE FOR BRAIN RESEARCH, INC.	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Biomedical Research and Research Training	000	2	6/29/2018	NON-COMPETING CONTINUATION	$2,308,176
														Subtotal = $2,308,176

Issue Date FY: 2017 ( Subtotal = $2,397,841 )
2017	2017	LAUREATE INSTITUTE FOR BRAIN RESEARCH, INC.	6655 S YALE AVE	TULSA	OK	74136	TULSA	USA	Biomedical Research and Research Training	000	1	9/15/2017	NEW	$2,397,841
														Subtotal = $2,397,841

Grand Total All Awards = $16,376,566

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The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP)

Award Number: P20GM121312

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2017

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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