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Wyoming Sensory Biology COBRE

Award Number: P20GM121310
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2017
PERIOD OF PERFORMANCE END DATE: 07/31/2023

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Wyoming Sensory Biology COBRE - The objective of this administrative supplement is to enhance our research capabilities in the transcriptomic characterization of the nervous system, and forge a more synergistic interaction among SBC investigators by promoting transcriptomic research and collaborations. These funds will be used to acquire a NextSeq550 Sequencing System (Illumina) that will significantly enhance SBC’s access to transcriptomic research, and strengthen the services provided by the Molecular Analysis Unit (MAU) of the Integrated Microscopy Core (IMCore). Over the past 4-year funding period, the IMCore has made significant advances towards assisting SBC project leaders with their research involving transcriptomics. Currently, there have already been single cell RNAseq and Chipseq experiments that have been conducted in the core, as evidenced in our recent publications. However, these experiments were only able to be carried out through shipping out samples to multiple third- party service centers and core facilities (e.g., Genewiz.com 10x genomics and Harvard Bauer Core Facilities). Although this approach has “sufficed”, several major issues hinder its application among SBC researchers: 1) the shipped samples require -80 degree Fahrenheit/Celsius storage, and transporting them in dry ice adds unnecessary variability to the sample qualities; 2) the quality controls of library preparations are highly variable as they are conducted by different commercial vendors that use different protocols; 3) lack of hands-on technical support inhibits application by new project leaders. Therefore, the purchase of the NextSeq550 will be a game changer for transcriptomic research at the University of Wyoming. We anticipate that the number of projects using single cell RNAseq or the Chipseq approach will increase significantly given the availability of the NextSeq550. The purchase of NextSeq550 is fully justifiable, reasonable, and allocable to grant projects – we currently have four new research projects that outline utilizing this instrument. Project 1: to identify state- dependent changes in neuronal transcription at the level of individual cells. Project 2: single-nucleus RNA-seq will be used to explore transcriptional heterogeneity in the medial prefrontal cortex with differential projections during stress-induced depression. Project 3: to investigate gene expression within reward-specific ensembles – defined as a discrete number of neurons that become synchronously activated – and how that differs in neurons that become activated during the seeking of different types of rewards. Project 4: to answer the following questions: (1) which genes are activated/repressed after injury and during regeneration, and (2) are the transcriptional profiles generated different based on injury mechanism and/or cell type. We anticipate that this administrative supplement will significantly help increase our access to transcriptomic research and collaboration, increase the number of projects that would utilize this instrument during the remainder of the funding period, and help build a strong foundation for Phase II applications.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$518 )
2025	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	002	5	1/13/2025	SUPPLEMENT FOR EXPANSION	-$51
2025	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	000	5	1/13/2025	NON-COMPETING CONTINUATION	-$359
2025	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	003	5	1/13/2025	SUPPLEMENT FOR EXPANSION	-$45
2025	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	001	5	1/13/2025	SUPPLEMENT FOR EXPANSION	-$63
														Subtotal = -$518

Issue Date FY: 2024 ( Subtotal = $2,730,469 )
2024	2024	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	005	8	8/8/2024	SUPPLEMENT FOR EXPANSION	$250,000
2024	2024	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	004	8	8/7/2024	NON-COMPETING CONTINUATION	$2,480,469
2024	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	001	7	1/19/2024	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	000	7	10/31/2023	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	003	7	3/22/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	002	7	3/5/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,730,469

Issue Date FY: 2023 ( Subtotal = $3,994,875 )
2023	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	011	7	9/11/2023	NON-COMPETING CONTINUATION	$0
2023	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	008	7	7/6/2023	NON-COMPETING CONTINUATION	$2,124,041
2023	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	010	7	8/29/2023	SUPPLEMENT FOR EXPANSION	$356,428
2023	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	012	7	9/15/2023	SUPPLEMENT FOR EXPANSION	$356,545
2023	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	009	7	7/10/2023	SUPPLEMENT FOR EXPANSION	$249,981
2023	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	013	7	9/20/2023	SUPPLEMENT FOR EXPANSION	$907,880
2023	2022	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	001	6	2/16/2023	COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	007	6	6/28/2023	COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	000	6	11/11/2022	COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	006	6	6/9/2023	COMPETING CONTINUATION	$223,295
2023	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	004	5	6/9/2023	SUPPLEMENT FOR EXPANSION	-$22,187
2023	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	005	5	6/9/2023	SUPPLEMENT FOR EXPANSION	-$19,300
2023	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	002	5	6/9/2023	NON-COMPETING CONTINUATION	-$154,718
2023	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	003	5	6/9/2023	SUPPLEMENT FOR EXPANSION	-$27,089
														Subtotal = $3,994,875

Issue Date FY: 2022 ( Subtotal = $2,006,157 )
2022	2022	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	002	6	9/1/2022	COMPETING CONTINUATION	$2,006,157
2022	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	001	5	8/31/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	000	5	6/24/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,006,157

Issue Date FY: 2021 ( Subtotal = $2,892,364 )
2021	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	001	5	7/19/2021	NON-COMPETING CONTINUATION	$2,004,078
2021	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	004	5	9/1/2021	SUPPLEMENT FOR EXPANSION	$250,000
2021	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	002	5	7/21/2021	SUPPLEMENT FOR EXPANSION	$350,893
2021	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	003	5	8/20/2021	SUPPLEMENT FOR EXPANSION	$287,393
2021	2020	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	000	4	4/23/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,892,364

Issue Date FY: 2020 ( Subtotal = $2,767,154 )
2020	2020	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	002	4	7/29/2020	SUPPLEMENT FOR EXPANSION	$144,500
2020	2020	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	001	4	7/14/2020	NON-COMPETING CONTINUATION	$2,030,998
2020	2020	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	004	4	7/31/2020	SUPPLEMENT FOR EXPANSION	$269,107
2020	2020	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	003	4	7/30/2020	SUPPLEMENT FOR EXPANSION	$322,549
2020	2019	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	000	3	2/1/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,767,154

Issue Date FY: 2019 ( Subtotal = $2,067,103 )
2019	2019	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	001	3	7/30/2019	NON-COMPETING CONTINUATION	$2,067,103
2019	2018	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	000	2	3/21/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,067,103

Issue Date FY: 2018 ( Subtotal = $2,400,084 )
2018	2018	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	001	2	9/13/2018	SUPPLEMENT FOR EXPANSION	$299,573
2018	2018	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	000	2	7/20/2018	NON-COMPETING CONTINUATION	$2,100,511
														Subtotal = $2,400,084

Issue Date FY: 2017 ( Subtotal = $1,941,052 ) (Continued on the next page)
Grand Total All Awards = $20,798,740

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Wyoming Sensory Biology COBRE

Award Number: P20GM121310

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2017

PERIOD OF PERFORMANCE END DATE: 07/31/2023

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