Friday, November 22, 2024 11/22/2024

Wyoming Sensory Biology COBRE

Award Number: P20GM121310
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract The primary mission of the Sensory Biology COBRE (SBC) is to foster and conduct high-quality scientific research that advances our understanding of human sensory systems and disorders related to them. A major role of the Center is to support and mentor the development of junior investigators to pursue research in sensory system function and dysfunction. During Phase I, the SBC spearheaded transformative changes in the landscape of Sensory Biology Research. In addition to basic research related to the fundamental mechanisms of sensory processing and the role of the sensory system in social and cognitive behaviors, SBC labs also focused on translational research in mental health and psychiatric disorders. For the Phase II period, the SBC will continue to tackle the most critical public health issues relevant to the State of Wyoming for the 21st century, including aging and chronic diseases and conditions such as Alzheimer’s disease and related dementias (AD/RD), amyotrophic lateral sclerosis (ALS), developmental disorders that affect communication and behavior in children (autism spectrum disorders, ASD), and recovery from spinal cord injury (SCI). The Phase II Center will support four initial project leaders who will study the key roles of novel circuits in neurological disorders: the role of the lateral parabrachial nucleus in sundowning associated with AD/RD; the role of the medial prefrontal cortex in ALS and AD/RD; the role of oxytocin neurons in the parvocellular nucleus in pro-social behavior and disruptions of social behavior in ASD; and the role of electrical signaling that drives inflammation and glia bridging in the recovery from SCI. SBC will enhance the research quality and output of the junior investigators by providing mentoring, collaboration, and training and by sharing resources and animal models. The successful execution of SBC’s Phase II goal will help propel the SBC into Phase III where SBC will become an independent, thriving, and sustainable Center of Excellence, comprised of over fifteen independently funded labs and a multi-disciplinary biomedical research program. To achieve this goal, we propose the following four specific aims for the Phase II period: Aim 1. Expand the research scope to tackle important health issues relevant to the State of Wyoming. Aim 2. Advance the Phase II center by providing more effective administrative oversight of the research, finance, mentoring, and evaluation activities. Aim 3. Enhance the operational efficiency and the long-term self-sustainability of the Core. Aim 4. Bolster the growth achieved during Phase I by leveraging Phase II financial resources to recruit new junior investigators and increase their integration into thematic programs. Support of Phase II is crucial to our efforts in building a sustainable research center in the State of Wyoming. The support of Phase II will garner the institutional support needed for the long-term self-sustainability of the Center post-IDeA funding.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $2,730,469 )
2024	2024	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	004	8	8/7/2024	NON-COMPETING CONTINUATION	$2,480,469
2024	2024	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	005	8	8/8/2024	SUPPLEMENT FOR EXPANSION	$250,000
2024	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	003	7	3/22/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	000	7	10/31/2023	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	002	7	3/5/2024	NON-COMPETING CONTINUATION	$0
2024	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	001	7	1/19/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,730,469

Issue Date FY: 2023 ( Subtotal = $3,994,875 )
2023	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	012	7	9/15/2023	SUPPLEMENT FOR EXPANSION	$356,545
2023	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	008	7	7/6/2023	NON-COMPETING CONTINUATION	$2,124,041
2023	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	009	7	7/10/2023	SUPPLEMENT FOR EXPANSION	$249,981
2023	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	010	7	8/29/2023	SUPPLEMENT FOR EXPANSION	$356,428
2023	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	011	7	9/11/2023	NON-COMPETING CONTINUATION	$0
2023	2023	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	013	7	9/20/2023	SUPPLEMENT FOR EXPANSION	$907,880
2023	2022	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	001	6	2/16/2023	COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	007	6	6/28/2023	COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	006	6	6/9/2023	COMPETING CONTINUATION	$223,295
2023	2022	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	000	6	11/11/2022	COMPETING CONTINUATION	$0
2023	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	003	5	6/9/2023	SUPPLEMENT FOR EXPANSION	-$27,089
2023	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	005	5	6/9/2023	SUPPLEMENT FOR EXPANSION	-$19,300
2023	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	004	5	6/9/2023	SUPPLEMENT FOR EXPANSION	-$22,187
2023	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	002	5	6/9/2023	NON-COMPETING CONTINUATION	-$154,718
														Subtotal = $3,994,875

Issue Date FY: 2022 ( Subtotal = $2,006,157 )
2022	2022	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	002	6	9/1/2022	COMPETING CONTINUATION	$2,006,157
2022	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	001	5	8/31/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	000	5	6/24/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,006,157

Issue Date FY: 2021 ( Subtotal = $2,892,364 )
2021	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	004	5	9/1/2021	SUPPLEMENT FOR EXPANSION	$250,000
2021	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	003	5	8/20/2021	SUPPLEMENT FOR EXPANSION	$287,393
2021	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	001	5	7/19/2021	NON-COMPETING CONTINUATION	$2,004,078
2021	2021	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	002	5	7/21/2021	SUPPLEMENT FOR EXPANSION	$350,893
2021	2020	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	000	4	4/23/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,892,364

Issue Date FY: 2020 ( Subtotal = $2,767,154 )
2020	2020	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	003	4	7/30/2020	SUPPLEMENT FOR EXPANSION	$322,549
2020	2020	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	004	4	7/31/2020	SUPPLEMENT FOR EXPANSION	$269,107
2020	2020	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	001	4	7/14/2020	NON-COMPETING CONTINUATION	$2,030,998
2020	2020	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	002	4	7/29/2020	SUPPLEMENT FOR EXPANSION	$144,500
2020	2019	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	000	3	2/1/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,767,154

Issue Date FY: 2019 ( Subtotal = $2,067,103 )
2019	2019	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	001	3	7/30/2019	NON-COMPETING CONTINUATION	$2,067,103
2019	2018	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	000	2	3/21/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,067,103

Issue Date FY: 2018 ( Subtotal = $2,400,084 )
2018	2018	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	001	2	9/13/2018	SUPPLEMENT FOR EXPANSION	$299,573
2018	2018	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	000	2	7/20/2018	NON-COMPETING CONTINUATION	$2,100,511
														Subtotal = $2,400,084

Issue Date FY: 2017 ( Subtotal = $1,941,052 )
2017	2017	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE DEPARTMENT 3434	LARAMIE	WY	82071	ALBANY	USA	Biomedical Research and Research Training	000	1	8/30/2017	NEW	$1,941,052
														Subtotal = $1,941,052

Grand Total All Awards = $20,799,258

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Wyoming Sensory Biology COBRE

Award Number: P20GM121310

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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