Thursday, October 30, 2025 10/30/2025

Center for Redox Biology and Cardiovascular Disease

Award Number: P20GM121307
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2018
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Center for Redox Biology and Cardiovascular Disease - PROJECT ABSTRACT Cardiovascular disease is the leading cause of death and disability in the United States with a disproportional effect on southern regions of the country. Louisiana is substantially affected by cardiovascular disease with nearly one quarter of deaths in the state attributed to it. While advances in cardiovascular treatments have been realized, many disease mechanisms remain poorly understood. It has become increasingly clear that changes in heart and vascular oxidant stress and antioxidant defenses, the so called ‘redox balance’, plays critical roles in disease initiation and propagation. However, specific disease mechanisms controlled by redox biology pathways remains poorly defined, which requires further study and research in this area. The Center for Redox Biology and Cardiovascular Disease (CRBCD) Phase 1 CoBRE at LSU Health Shreveport brought together numerous junior investigators with state-of-the-art knowledge and expertise across different departments to address redox biology molecular mechanisms contributing to cardiovascular pathophysiology. The intent of this Phase 2 proposal is to continue growth of the CRBCD CoBRE and continue recruitment of junior faculty to the program and institution to increase competitiveness of major research grant programs. Individual junior faculty primary projects have been chosen based on their relevance to the research theme, novelty of the research topic regarding redox biology and cardiovascular disease, and their potential ability to achieve independent major research funding. Cutting edge research core facilities have begun and will continue to grow to serve the needs of the CoBRE program, institution, and others across the nation. The CRBCD CoBRE has also greatly benefitted from a world class advisory committee that remains committed to continue providing input and advise throughout the Phase 2 program. Together, the proposed projects will provide advanced understanding of redox biology pathophysiology mechanisms during cardiovascular disease with support from advanced, state of the art animal models and redox molecular pathology research core facilities. Research and professional development programs are also proposed that will provide continued growth and leadership for all associated participants and trainees.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,172,749 )
2025	2025	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	001	8	9/23/2025	NON-COMPETING CONTINUATION	$0
2025	2025	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	000	8	7/17/2025	NON-COMPETING CONTINUATION	$2,172,749
														Subtotal = $2,172,749

Issue Date FY: 2024 ( Subtotal = $2,134,374 )
2024	2024	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	004	7	7/23/2024	NON-COMPETING CONTINUATION	$2,134,374
2024	2024	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	006	7	9/18/2024	NON-COMPETING CONTINUATION	$0
2024	2024	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	005	7	8/6/2024	NON-COMPETING CONTINUATION	$0
2024	2023	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	003	6	3/13/2024	COMPETING CONTINUATION	$246,001
2024	2023	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	000	6	12/6/2023	COMPETING CONTINUATION	$0
2024	2022	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	001	5	3/13/2024	NON-COMPETING CONTINUATION	-$182,261
2024	2022	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	002	5	3/13/2024	SUPPLEMENT FOR EXPANSION	-$63,740
														Subtotal = $2,134,374

Issue Date FY: 2023 ( Subtotal = $2,141,476 )
2023	2023	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	003	6	6/30/2023	COMPETING CONTINUATION	$2,141,476
2023	2022	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	001	5	6/29/2023	NON-COMPETING CONTINUATION	$0
2023	2022	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	002	5	6/29/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2022	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	000	5	10/13/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,141,476

Issue Date FY: 2022 ( Subtotal = $2,817,399 )
2022	2022	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	002	5	6/14/2022	SUPPLEMENT FOR EXPANSION	$730,000
2022	2022	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	000	5	2/4/2022	NON-COMPETING CONTINUATION	$1,878,658
2022	2022	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	001	5	5/17/2022	NON-COMPETING CONTINUATION	$208,741
														Subtotal = $2,817,399

Issue Date FY: 2021 ( Subtotal = $2,799,349 )
2021	2021	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	003	4	9/6/2021	NON-COMPETING CONTINUATION	$0
2021	2021	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	000	4	1/22/2021	NON-COMPETING CONTINUATION	$1,862,413
2021	2021	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	004	4	9/16/2021	NON-COMPETING CONTINUATION	$0
2021	2021	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	001	4	2/12/2021	NON-COMPETING CONTINUATION	$206,936
2021	2021	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	002	4	5/28/2021	SUPPLEMENT FOR EXPANSION	$730,000
														Subtotal = $2,799,349

Issue Date FY: 2020 ( Subtotal = $2,281,524 )
2020	2020	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	000	3	1/20/2020	NON-COMPETING CONTINUATION	$1,881,437
2020	2020	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	002	3	7/9/2020	NON-COMPETING CONTINUATION	$0
2020	2020	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	001	3	2/21/2020	NON-COMPETING CONTINUATION	$209,049
2020	2020	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	003	3	9/3/2020	SUPPLEMENT FOR EXPANSION	$191,038
														Subtotal = $2,281,524

Issue Date FY: 2019 ( Subtotal = $2,425,048 )
2019	2019	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	002	2	5/10/2019	NON-COMPETING CONTINUATION	$0
2019	2019	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	003	2	8/14/2019	SUPPLEMENT FOR EXPANSION	$330,928
2019	2019	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	001	2	2/13/2019	NON-COMPETING CONTINUATION	$0
2019	2019	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	000	2	1/23/2019	NON-COMPETING CONTINUATION	$2,094,120
														Subtotal = $2,425,048

Issue Date FY: 2018 ( Subtotal = $2,502,231 )
2018	2018	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	000	1	1/26/2018	NEW	$2,238,822
2018	2018	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	002	1	9/20/2018	SUPPLEMENT FOR EXPANSION	$0
2018	2018	LOUISIANA STATE UNIVERSITY	1501 KINGS HWY	SHREVEPORT	LA	71103	CADDO	USA	Biomedical Research and Research Training	001	1	9/13/2018	SUPPLEMENT FOR EXPANSION	$263,409
														Subtotal = $2,502,231

Grand Total All Awards = $19,274,150

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Center for Redox Biology and Cardiovascular Disease

Award Number: P20GM121307

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2018

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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