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Center for Translational Pediatric Research

Award Number: P20GM121293
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/11/2017
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Center for Translational Pediatric Research - Summary In July of 2017, we launched Phase I of the COBRE Center for Translational Pediatric Research at Arkansas Children’s Research Institute in Little Rock, Arkansas. The mission of the center is to use proteogenomic approaches to identify epigenomic mechanisms and therapeutic targets in diseases, including cancer, impacting or translatable to the pediatric population. The unifying theme of research among center members is utilizing systems biology approaches and sophisticated bioinformatics for studying disease mechanism. The goal of Phase I was to establish the foundation of the center, expand the pool of successful investigators with a Faculty Development Plan, and support systems-level core resources. Towards this goal, the center was created with a nucleus of 4 Research Project Leaders and 2 research cores, Proteomics Core and Genomics & Bioinformatics Core. Through use of a mentored Faculty Development Program overseen by the Administrative Core, the junior investigators from Phase I received 9 RPG-level grants, including an U01-award. Additionally, we were able to “graduate” both Phase I research cores to self-sustainability. Collectively, during the past 4 years of Phase I, we have made substantial progress towards establishing a multi-disciplinary, thematic research center through expansion of our center members, transitioning core resources to independence, and extramural funding – demonstrating how the center is moving in the direction of long-term sustainability beyond COBRE support. Building on the momentum of Phase I, our goals in Phase II are to further enhance our institutional research infrastructure by developing our multi-disciplinary, thematic research center through strategic expansion of the critical mass of investigators, investing into research infrastructure, and implementing a plan for long-term center sustainability beyond COBRE support. We will provide structured mentoring and support to an initial group of 5 Research Project Leaders in Phase II. Furthermore, we will expand the pool of investigators in the center through institutional commitments to recruit 4 Assistant and 1 Associate or Full Professor to the center. To support needs of the expanding critical mass of investigators, we will develop a new Proteogenomics Core that is essential for the evolving research mission of the center. This unique core will provide Research Project Leaders and other center members access to experienced personnel for non-standard proteomic, genomic, and epigenomic applications, and access to highly skilled bioinformaticians for cutting-edge data analysis and integration. To support the expansion of investigators and a new research core, the Administrative Core will provide a Faculty Development Plan, Pilot Project Program, operational oversight, and leadership as the center prepares to transition to long-term sustainability. Upon completion of Phase II, we anticipate having a critical mass of junior, mid-career, and senior investigators in the center who have access to world-class systems biology cores, which will enable center members to successfully compete for individual, multi-investigator, and program-level grants to support transition of the center to long-term sustainability beyond COBRE support.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $2,303,000 )
2024	2024	ARKANSAS CHILDREN'S RESEARCH INSTITUTE	13 CHILDREN'S WAY	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	000	8	8/16/2024	NON-COMPETING CONTINUATION	$2,303,000
														Subtotal = $2,303,000

Issue Date FY: 2023 ( Subtotal = $3,258,666 )
2023	2023	ARKANSAS CHILDREN'S RESEARCH INSTITUTE	13 CHILDREN'S WAY	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	005	7	7/6/2023	NON-COMPETING CONTINUATION	$2,303,000
2023	2023	ARKANSAS CHILDREN'S RESEARCH INSTITUTE	13 CHILDREN'S WAY	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	006	7	9/15/2023	SUPPLEMENT FOR EXPANSION	$955,666
2023	2022	ARKANSAS CHILDREN'S RESEARCH INSTITUTE	13 CHILDREN'S WAY	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	004	6	4/13/2023	COMPETING CONTINUATION	$1,507,163
2023	2022	ARKANSAS CHILDREN'S RESEARCH INSTITUTE	13 CHILDREN'S WAY	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	001	6	2/15/2023	COMPETING CONTINUATION	$0
2023	2022	ARKANSAS CHILDREN'S RESEARCH INSTITUTE	13 CHILDREN'S WAY	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	000	6	11/11/2022	COMPETING CONTINUATION	$0
2023	2021	ARKANSAS CHILDREN'S RESEARCH INSTITUTE	13 CHILDREN'S WAY	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	003	5	4/13/2023	SUPPLEMENT FOR EXPANSION	-$378,635
2023	2021	ARKANSAS CHILDREN'S RESEARCH INSTITUTE	13 CHILDREN'S WAY	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	002	5	4/13/2023	NON-COMPETING CONTINUATION	-$1,128,529
														Subtotal = $3,258,666

Issue Date FY: 2022 ( Subtotal = $3,100,000 )
2022	2022	AR CHILDRENS HOSPITAL RESEARCH INSTITUTE	13 CHILDRENS WAY STE 842	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	003	6	8/15/2022	SUPPLEMENT FOR EXPANSION	$770,000
2022	2022	AR CHILDRENS HOSPITAL RESEARCH INSTITUTE	13 CHILDRENS WAY STE 842	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	002	6	7/20/2022	COMPETING CONTINUATION	$2,330,000
2022	2022	ARKANSAS CHILDREN'S RESEARCH INSTITUTE	13 CHILDREN'S WAY	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	004	6	9/23/2022	COMPETING CONTINUATION	$0
2022	2021	AR CHILDRENS HOSPITAL RESEARCH INSTITUTE	13 CHILDRENS WAY STE 842	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	000	5	1/27/2022	NON-COMPETING CONTINUATION	$0
2022	2021	AR CHILDRENS HOSPITAL RESEARCH INSTITUTE	13 CHILDRENS WAY STE 842	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	001	5	7/19/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,100,000

Issue Date FY: 2021 ( Subtotal = $3,065,000 )
2021	2021	AR CHILDRENS HOSPITAL RESEARCH INSTITUTE	13 CHILDRENS WAY STE 842	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	001	5	6/23/2021	SUPPLEMENT FOR EXPANSION	$770,000
2021	2021	AR CHILDRENS HOSPITAL RESEARCH INSTITUTE	13 CHILDRENS WAY STE 842	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	000	5	6/10/2021	NON-COMPETING CONTINUATION	$2,295,000
2021	2021	AR CHILDRENS HOSPITAL RESEARCH INSTITUTE	13 CHILDRENS WAY STE 842	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	002	5	8/25/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,065,000

Issue Date FY: 2020 ( Subtotal = $2,566,685 )
2020	2020	AR CHILDRENS HOSPITAL RESEARCH INSTITUTE	13 CHILDRENS WAY STE 842	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	000	4	8/10/2020	NON-COMPETING CONTINUATION	$2,271,150
2020	2020	AR CHILDRENS HOSPITAL RESEARCH INSTITUTE	13 CHILDRENS WAY STE 842	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	001	4	8/28/2020	SUPPLEMENT FOR EXPANSION	$295,535
														Subtotal = $2,566,685

Issue Date FY: 2019 ( Subtotal = $2,295,000 )
2019	2019	AR CHILDRENS HOSPITAL RESEARCH INSTITUTE	13 CHILDRENS WAY STE 842	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	001	3	7/24/2019	NON-COMPETING CONTINUATION	$2,295,000
2019	2019	AR CHILDRENS HOSPITAL RESEARCH INSTITUTE	13 CHILDRENS WAY STE 842	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	002	3	8/27/2019	NON-COMPETING CONTINUATION	$0
2019	2018	AR CHILDRENS HOSPITAL RESEARCH INSTITUTE	13 CHILDRENS WAY STE 842	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	000	2	2/14/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,295,000

Issue Date FY: 2018 ( Subtotal = $2,295,000 )
2018	2018	AR CHILDRENS HOSPITAL RESEARCH INSTITUTE	13 CHILDRENS WAY STE 842	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	000	2	6/29/2018	NON-COMPETING CONTINUATION	$2,295,000
														Subtotal = $2,295,000

Issue Date FY: 2017 ( Subtotal = $2,295,000 )
2017	2017	AR CHILDRENS HOSPITAL RESEARCH INSTITUTE	13 CHILDRENS WAY STE 842	LITTLE ROCK	AR	72202	PULASKI	USA	Biomedical Research and Research Training	000	1	7/11/2017	NEW	$2,295,000
														Subtotal = $2,295,000

Grand Total All Awards = $21,178,351

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Center for Translational Pediatric Research

Award Number: P20GM121293

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/11/2017

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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