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The Institute for Biomolecular Targeting - Lacefield Supplement

Award Number: P20GM113132
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/15/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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The Institute for Biomolecular Targeting - Lacefield Supplement - The Dartmouth Institute for Biomolecular Targeting (bioMT) infuses mechanistic investigations with a sophisticated awareness of disease pathology and therapeutic need, enhancing the quality of even the most fundamental research. At the same time, it helps orient mechanistic investigations towards long-term translational goals for complex diseases such as cancer and infections. In phase I, our progress was strong. All six of our research project leaders (RPL) with more than two years’ support have received R01-equivalent funding. Our cores provide unique protein biochemistry resources and ‘navigators’ to access microscopes campus-wide. Our cores and seminars have created a vibrant and interdisciplinary community. Here, we propose to deploy phase II COBRE and institutional program enrichment funds to build on this foundation and fill key gaps to prepare bioMT for the transition to sustainable COBRE independence. Aim 1 is to increase our cohort of funded bioMT investigators to fill strategic roles in our research landscape. Our two most recent RPLs (3–15 months’ support) are continuing into phase II, joined by two outstanding new hires. Their projects explore basic signaling and immunological mechanisms with potential relevance to therapeutic targets ranging from respiratory infections to cancer progression and metastasis, interconnected by shared scientific and technical interests. All receive guidance from dedicated mentoring dyads to assist in career advancement and independent extramural funding, and all receive support from responsive scientific cores offering state-of-the- art technologies directly relevant to their bioMT research projects. With institutional support, we will also hire five new faculty members, aligned with our theme of discovering and exploiting molecular targets, and selected to enhance thematic subgroups. As starting RPLs graduate, we will recruit new hires and other potential candidates for EAC consideration as replacements. Aim 2 is to enhance our core facilities and prepare them for a transition to COBRE independence during phase III. The cores are fully staffed and have invested heavily in phase I instrumentation. We will partner to add key new technologies based on user input, including parallel protein expression, mass spectrometry, advanced microscopy, and cryoEM. Cost-recovery models will be developed for incremental deployment in phase III to enable core financial independence. Aim 3 continues enriching our community, including mini-symposia and pilot awards to foster new multi-PI and program-project applications, which will contribute to core sustainability. Overall, these aims will leverage proven COBRE strategies – junior faculty hiring, extramural and academic mentoring, excellent administrative and scientific core support, and interdisciplinary community building – to enhance bioMT’s scientific impact in targeted areas of need. This will prepare us for the transition to phase III funding and ultimate independence as an interdisciplinary and nationally visible research institute, spanning three schools and 10 departments at Dartmouth and deeply connected to local centers and regional IDeA partners.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $3,013,120 )
2024	2024	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	003	9	8/22/2024	SUPPLEMENT FOR EXPANSION	$250,000
2024	2024	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	002	9	6/11/2024	NON-COMPETING CONTINUATION	$2,460,000
2024	2024	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	004	9	8/23/2024	SUPPLEMENT FOR EXPANSION	$303,120
2024	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	001	8	3/14/2024	NON-COMPETING CONTINUATION	$0
2024	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	000	8	11/6/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,013,120

Issue Date FY: 2023 ( Subtotal = $2,460,000 )
2023	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	001	8	9/18/2023	NON-COMPETING CONTINUATION	$0
2023	2023	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	000	8	8/10/2023	NON-COMPETING CONTINUATION	$2,460,000
														Subtotal = $2,460,000

Issue Date FY: 2022 ( Subtotal = $2,690,023 )
2022	2022	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	005	7	7/13/2022	NON-COMPETING CONTINUATION	$0
2022	2022	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	006	7	8/26/2022	SUPPLEMENT FOR EXPANSION	$230,023
2022	2022	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	004	7	6/16/2022	NON-COMPETING CONTINUATION	$2,460,000
2022	2021	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	001	6	4/7/2022	COMPETING CONTINUATION	$161,406
2022	2021	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	002	6	5/18/2022	COMPETING CONTINUATION	$0
2022	2021	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	003	6	6/1/2022	COMPETING CONTINUATION	$0
2022	2020	TRUSTEES OF DARTMOUTH COLLEGE	7 LEBANON ST	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	000	5	4/7/2022	SUPPLEMENT FOR EXPANSION	-$161,406
														Subtotal = $2,690,023

Issue Date FY: 2021 ( Subtotal = $2,460,000 )
2021	2021	TRUSTEES OF DARTMOUTH COLLEGE	6001 PARKHURST HALL STE 207	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	003	6	7/31/2021	COMPETING CONTINUATION	$2,460,000
2021	2020	TRUSTEES OF DARTMOUTH COLLEGE	6001 PARKHURST HALL STE 207	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	002	5	7/30/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	TRUSTEES OF DARTMOUTH COLLEGE	6001 PARKHURST HALL STE 207	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	001	5	7/30/2021	NON-COMPETING CONTINUATION	$0
2021	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	000	5	1/28/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,460,000

Issue Date FY: 2020 ( Subtotal = $2,661,950 )
2020	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	001	5	2/26/2020	NON-COMPETING CONTINUATION	$2,430,000
2020	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	002	5	6/11/2020	SUPPLEMENT FOR EXPANSION	$231,950
2020	2020	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	003	5	8/3/2020	NON-COMPETING CONTINUATION	$0
2020	2019	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	000	4	1/29/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,661,950

Issue Date FY: 2019 ( Subtotal = $2,430,000 )
2019	2019	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	002	4	6/24/2019	NON-COMPETING CONTINUATION	$0
2019	2019	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	003	4	7/25/2019	NON-COMPETING CONTINUATION	$0
2019	2019	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	001	4	2/27/2019	NON-COMPETING CONTINUATION	$2,430,000
2019	2018	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	000	3	2/8/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,430,000

Issue Date FY: 2018 ( Subtotal = $2,430,000 )
2018	2018	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	002	3	9/7/2018	NON-COMPETING CONTINUATION	$0
2018	2018	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	001	3	5/14/2018	NON-COMPETING CONTINUATION	$243,000
2018	2018	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	000	3	2/27/2018	NON-COMPETING CONTINUATION	$2,187,000
2018	2018	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	003	3	9/19/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,430,000

Issue Date FY: 2017 ( Subtotal = $2,566,493 )
2017	2017	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	002	2	9/12/2017	SUPPLEMENT FOR EXPANSION	$136,493
2017	2017	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	001	2	7/10/2017	NON-COMPETING CONTINUATION	$243,000
2017	2017	TRUSTEES OF DARTMOUTH COLLEGE	1 HINMAN DARTMOUTH COLLEGE	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	000	2	2/23/2017	NON-COMPETING CONTINUATION	$2,187,000
														Subtotal = $2,566,493

Issue Date FY: 2016 ( Subtotal = $2,730,000 )
2016	2016	DARTMOUTH COLLEGE	11 ROPE FERRY ROAD, #6210	HANOVER	NH	03755	GRAFTON	USA	Biomedical Research and Research Training	000	1	5/13/2016	NEW	$2,730,000
														Subtotal = $2,730,000

Grand Total All Awards = $23,441,586

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The Institute for Biomolecular Targeting - Lacefield Supplement

Award Number: P20GM113132

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/15/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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