Monday, July 14, 2025 7/14/2025

Center for Integrative Research on Childhood Adversity

Award Number: P20GM109097
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2016
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Center for Integrative Research on Childhood Adversity - ABSTRACT The goal of this Phase 2 CoBRE application is to expand on the accomplishments of Phase 1 in establishing an interdisciplinary and translational Center for Integrative Research on Childhood Adversity (CIRCA) at Oklahoma State University (OSU). Two decades of epidemiological data document that Adverse Childhood Experiences (ACEs) are prevalent and cumulative, have enduring negative consequences for physical and mental health, and cost north America more than $758B in preventable health care. In order to reduce the costly effects of ACEs, research is increasingly focused on identifying mechanisms and processes by which ACEs impact developing nervous, endocrine, metabolic, and immune systems, and intergenerational biobehavioral pathways of transmission, as well as potential pathways for prevention, recovery, and healing. This research is interdisciplinary by design and reliant on a team science approach, requiring researchers with the capacity to collaborate in transdisciplinary teams.14, 15 The goals of CIRCA during Phase 1 were to increase institutional research infrastructure to support a cadre of collaborative investigators achieve independent funding on adversity and resilience. OSU invested approximately $10M in facilities, equipment, faculty, and staff, significantly increasing capacity for biobehavioral research on adversity. The 5 research project leaders (RPLs) and 8 pilot project leaders in Phase 1 obtained $16.3M in external grant support, with an $8.2M increase in NIH funding. Phase 2 will expand and strengthen this interdisciplinary and collaborative center of biomedical research excellence by a) building institutional and center infrastructure using a team science approach; b) supporting and mentoring early-career investigators in their programs of research; c) developing vibrant, sustainable research cores; and d) generating innovative transdisciplinary approaches focused on the synergistic impacts of genetic, biological, environmental, and developmental influences on risk and resilience over the life course. Phase 2 projects will investigate neurobiological mechanisms and developmental processes linking childhood adversity with subsequent health problems using a theoretical framework developed by CIRCA investigators during Phase 1. The proposed research projects and planned pilot projects will be supported by an Administrative Core, a Recruitment, Engagement, Collection, and Assessment (RECA) Core and a Biological Systems Core. Each project will contribute to a common set of biological and behavioral measures, establishing a sustainable CIRCA Databank for current and future research. This proposed Phase 2 CoBRE is highly innovative in that it addresses the need to prepare a new generation of scientists with the capacity to identify and target the biobehavioral and developmental processes linking early life adversity with negative health outcomes. It is significant in that it will create a sustainable center providing opportunities for collaboration and a biobehavioral databank for current and future investigators in a region characterized by high rates of ACEs and historical trauma.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	OKLAHOMA STATE UNIVERSITY	1111 W 17TH ST	TULSA	OK	74107	TULSA	USA	Biomedical Research and Research Training	000	8	6/9/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $1,844,721 )
2024	2024	OKLAHOMA STATE UNIVERSITY	1111 W 17TH ST	TULSA	OK	74107	TULSA	USA	Biomedical Research and Research Training	001	8	9/12/2024	NON-COMPETING CONTINUATION	$1,844,721
2024	2023	OKLAHOMA STATE UNIVERSITY	1111 W 17TH ST	TULSA	OK	74107	TULSA	USA	Biomedical Research and Research Training	000	7	5/6/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,844,721

Issue Date FY: 2023 ( Subtotal = $1,887,090 )
2023	2023	OKLAHOMA STATE UNIVERSITY	1111 W 17TH ST	TULSA	OK	74107	TULSA	USA	Biomedical Research and Research Training	002	7	8/10/2023	NON-COMPETING CONTINUATION	$1,887,090
2023	2022	OKLAHOMA STATE UNIVERSITY	1111 W 17TH ST	TULSA	OK	74107	TULSA	USA	Biomedical Research and Research Training	001	6	4/10/2023	COMPETING CONTINUATION	$156,536
2023	2020	OKLAHOMA STATE UNIVERSITY	1111 W 17TH ST	TULSA	OK	74107	TULSA	USA	Biomedical Research and Research Training	000	5	4/10/2023	NON-COMPETING CONTINUATION	-$156,536
														Subtotal = $1,887,090

Issue Date FY: 2022 ( Subtotal = $1,960,968 )
2022	2022	OKLAHOMA STATE UNIVERSITY	1111 W 17TH ST	TULSA	OK	74107	TULSA	USA	Biomedical Research and Research Training	002	6	9/5/2022	COMPETING CONTINUATION	$1,960,968
2022	2020	OKLAHOMA STATE UNIVERSITY	1111 W 17TH ST	TULSA	OK	74107	TULSA	USA	Biomedical Research and Research Training	001	5	9/4/2022	NON-COMPETING CONTINUATION	$0
2022	2020	OKLAHOMA STATE UNIVERSITY	1111 W 17TH ST	TULSA	OK	74107	TULSA	USA	Biomedical Research and Research Training	000	5	3/21/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,960,968

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	OKLAHOMA STATE UNIVERSITY	1111 W 17TH ST	TULSA	OK	74107	TULSA	USA	Biomedical Research and Research Training	001	5	9/17/2021	NON-COMPETING CONTINUATION	$0
2021	2020	OKLAHOMA STATE UNIVERSITY	1111 W 17TH ST	TULSA	OK	74107	TULSA	USA	Biomedical Research and Research Training	000	5	2/19/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $2,093,771 )
2020	2020	OKLAHOMA STATE UNIVERSITY	1111 W 17TH ST	TULSA	OK	74107	TULSA	USA	Biomedical Research and Research Training	000	5	4/14/2020	NON-COMPETING CONTINUATION	$2,093,771
														Subtotal = $2,093,771

Issue Date FY: 2019 ( Subtotal = $2,306,846 )
2019	2019	OKLAHOMA STATE UNIVERSITY	1111 W 17TH ST	TULSA	OK	74107	TULSA	USA	Biomedical Research and Research Training	001	4	5/1/2019	NON-COMPETING CONTINUATION	$2,306,846
2019	2019	OKLAHOMA STATE UNIVERSITY	1111 W 17TH ST	TULSA	OK	74107	TULSA	USA	Biomedical Research and Research Training	002	4	8/28/2019	NON-COMPETING CONTINUATION	$0
2019	2018	OKLAHOMA STATE UNIVERSITY	1111 W 17TH ST	TULSA	OK	74107	TULSA	USA	Biomedical Research and Research Training	000	3	11/23/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,306,846

Issue Date FY: 2018 ( Subtotal = $2,260,530 )
2018	2018	OKLAHOMA STATE UNIVERSITY	1111 W 17TH ST	TULSA	OK	74107	TULSA	USA	Biomedical Research and Research Training	000	3	5/25/2018	NON-COMPETING CONTINUATION	$2,260,530
														Subtotal = $2,260,530

Issue Date FY: 2017 ( Subtotal = $2,323,779 )
2017	2017	OKLAHOMA STATE UNIVERSITY	1111 W 17TH ST	TULSA	OK	74107	TULSA	USA	Biomedical Research and Research Training	000	2	5/3/2017	NON-COMPETING CONTINUATION	$2,091,401
2017	2017	OKLAHOMA STATE UNIVERSITY	1111 W 17TH ST	TULSA	OK	74107	TULSA	USA	Biomedical Research and Research Training	001	2	7/10/2017	NON-COMPETING CONTINUATION	$232,378
														Subtotal = $2,323,779

Issue Date FY: 2016 ( Subtotal = $2,367,310 )
2016	2016	OKLAHOMA STATE UNIVERSITY CHS	1111 WEST 17TH STREET	TULSA	OK	74107	TULSA	USA	Biomedical Research and Research Training	000	1	6/29/2016	NEW	$2,367,310
														Subtotal = $2,367,310

Grand Total All Awards = $17,045,015

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Center for Integrative Research on Childhood Adversity

Award Number: P20GM109097

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2016

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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