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Role of mechanical stress in mitigating chemotherapy-associated bone loss

Award Number: P20GM109095
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2014
PERIOD OF PERFORMANCE END DATE: 05/31/2024

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Role of mechanical stress in mitigating chemotherapy-associated bone loss - PROJECT SUMMARY/ABSTRACT The Center of Biomedical Research Excellence in Matrix Biology administrative supplement will support women’s health research in an IDeA state, specifically Idaho. The results of this study will enhance our understanding of how bone health may be maintained for breast cancer survivors and those who have undergone chemotherapy. This question is at the foundation of concerns for women who have had breast cancer treatment and who are therefore at an increased risk for osteoporosis and fracture. The risk of developing breast cancer increases with age and is particularly high in women age 60 and older. Because of their age, these women are already at an increased risk for osteoporosis. Case rates in Idaho are higher than the national average, and much higher for some of the more rural counties within Idaho. Prevention and therapeutic interventions are needed to minimize bone loss and reduce fracture risk in this large and growing population. The proposed work will leverage resources available at Boise State University, specifically the Biomolecular Research Core and the RNA sequencing laboratory. The objective for this project is to investigate low-intensity vibration-induced improvements in both DNA damage repair in mesenchymal stem cells, osteoblast differentiation, and extracellular matrix production during cisplatin treatment. Results from this project will yield a greater understanding of how external mechanical force is involved in maintaining bone health during anti-cancer treatment. At the completion of the proposed experiments, we anticipate a greater understanding of non-pharmacologic and targeted therapeutic interventions to decrease long-term sequelae following chemotherapy. The results of the proposed work may reduce bone fractures, cancer metastasis, and recurrence. Additionally, this administrative supplement will expand the research and research capacity to conduct women’s health research in the state of Idaho.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $3,111,222 )
2023	2023	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	004	10	9/14/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2023	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	003	10	9/5/2023	SUPPLEMENT FOR EXPANSION	$280,294
2023	2023	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	001	10	6/14/2023	NON-COMPETING CONTINUATION	$2,107,499
2023	2023	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	002	10	8/24/2023	SUPPLEMENT FOR EXPANSION	$723,429
2023	2022	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	9	12/19/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,111,222

Issue Date FY: 2022 ( Subtotal = $2,808,518 )
2022	2022	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	001	9	6/8/2022	NON-COMPETING CONTINUATION	$2,107,499
2022	2022	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	002	9	6/20/2022	SUPPLEMENT FOR EXPANSION	$701,019
2022	2021	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	8	3/1/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,808,518

Issue Date FY: 2021 ( Subtotal = $2,329,207 )
2021	2021	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	002	8	6/1/2021	NON-COMPETING CONTINUATION	$2,107,499
2021	2021	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	003	8	8/13/2021	SUPPLEMENT FOR EXPANSION	$221,708
2021	2020	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	001	7	4/9/2021	NON-COMPETING CONTINUATION	$0
2021	2020	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	7	1/28/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,329,207

Issue Date FY: 2020 ( Subtotal = $2,107,499 )
2020	2020	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	002	7	7/30/2020	NON-COMPETING CONTINUATION	$2,107,499
2020	2019	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	001	6	5/8/2020	COMPETING CONTINUATION	$0
2020	2018	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	5	4/25/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,107,499

Issue Date FY: 2019 ( Subtotal = $2,107,499 )
2019	2019	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	001	6	7/25/2019	COMPETING CONTINUATION	$2,107,499
2019	2018	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	5	7/19/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,107,499

Issue Date FY: 2018 ( Subtotal = $1,954,982 )
2018	2018	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	5	5/22/2018	NON-COMPETING CONTINUATION	$1,954,982
2018	2018	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	001	5	9/19/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,954,982

Issue Date FY: 2017 ( Subtotal = $1,984,013 )
2017	2017	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	4	5/30/2017	NON-COMPETING CONTINUATION	$1,984,013
														Subtotal = $1,984,013

Issue Date FY: 2016 ( Subtotal = $2,302,777 )
2016	2016	BOISE STATE UNIVERSITY	1910 UNIVERSITY DRIVE	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	3	7/5/2016	NON-COMPETING CONTINUATION	$2,012,176
2016	2016	BOISE STATE UNIVERSITY	1910 UNIVERSITY DRIVE	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	001	3	8/15/2016	SUPPLEMENT FOR EXPANSION	$290,601
														Subtotal = $2,302,777

Issue Date FY: 2015 ( Subtotal = $2,039,509 )
2015	2015	BOISE STATE UNIVERSITY	1910 UNIVERSITY DRIVE	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	2	5/13/2015	NON-COMPETING CONTINUATION	$2,039,509
														Subtotal = $2,039,509

Issue Date FY: 2014 ( Subtotal = $1,996,464 )
2014	2014	BOISE STATE UNIVERSITY	1910 UNIVERSITY DRIVE	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	1	7/25/2014	NEW	$1,996,464
														Subtotal = $1,996,464

Grand Total All Awards = $22,741,690

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Role of mechanical stress in mitigating chemotherapy-associated bone loss

Award Number: P20GM109095

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2014

PERIOD OF PERFORMANCE END DATE: 05/31/2024

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