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Center of Biomedical Research Excellence in Matrix Biology Phase II

Award Number: P20GM109095
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2014
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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Center of Biomedical Research Excellence in Matrix Biology Phase II - Project Summary/Abstract - Overall The long-term goal of the Center of Biomedical Research Excellence (COBRE) in Matrix Biology is to establish, enhance, and actively advance a multidisciplinary research center focusing on improving our understanding of the role of the extracellular matrix in development, health, and disease, and contributing to the prevention, treatment, and cure for diseases of high priority. Since the beginning of Phase I in 2014, we have vigorously intervened limitations that hinder achieving our goals. Program accomplishments resulting from career development and mentoring of junior investigators led to an increase in research grant awards during Phase I. We accomplished an increase in access to and use of shared instrumentation within the COBRE Core facilities. Most importantly, a culture shift has occurred at Boise State University. Seven investigators received significant new funding and graduated from the COBRE mentoring program. The Pilot Project Program contributed to investigator success and served as an onramp for two of our Research Project Investigators working toward R01 grant submission during Phase II. A critical mass of investigators has been established around the thematic focus of matrix biology that includes a diverse cadre from disciplines including biology, chemistry, physics, materials science, computer science, mechanical and biomedical engineering, and electrical engineering. The COBRE program has put Boise State in a position to make significant contributions to solutions addressing national health concerns. New laboratories have been built and core facilities have been established supporting proteomics and metabolomics, histology, microscopy, imaging, and biostatistics/bioinformatics. COBRE investigators published 98 peer-reviewed manuscripts including noteworthy articles in journals of high impact. Phase II is critically important for us to continue our upward momentum toward our goals of research growth over the next five years. To achieve this overarching goal, four specific aims are proposed: 1) enhance and grow upon the critical mass of investigators established around the thematic multidisciplinary focus of matrix biology, 2) enhance biomedical research core capabilities, 3) grow research collaborations with existing programs, and 4) enhance research training opportunities. Upon successful completion of the proposed aims, we will have strengthened and enhanced the critical mass of investigators with shared priorities in understanding the role of the matrix in development and disease. Shared core facilities will be enhanced and will support the needs of more investigators as they follow a mentored career development plan. The multidisciplinary nature that was established in Phase I will continue to grow to include additional investigators across our institution.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$111,842 )
2026	2023	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	10	1/17/2026	NON-COMPETING CONTINUATION	$0
2026	2023	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	001	10	2/11/2026	NON-COMPETING CONTINUATION	-$111,842
														Subtotal = -$111,842

Issue Date FY: 2023 ( Subtotal = $3,111,222 )
2023	2023	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	004	10	9/14/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2023	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	003	10	9/5/2023	SUPPLEMENT FOR EXPANSION	$280,294
2023	2023	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	001	10	6/14/2023	NON-COMPETING CONTINUATION	$2,107,499
2023	2023	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	002	10	8/24/2023	SUPPLEMENT FOR EXPANSION	$723,429
2023	2022	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	9	12/19/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,111,222

Issue Date FY: 2022 ( Subtotal = $2,808,518 )
2022	2022	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	001	9	6/8/2022	NON-COMPETING CONTINUATION	$2,107,499
2022	2022	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	002	9	6/20/2022	SUPPLEMENT FOR EXPANSION	$701,019
2022	2021	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	8	3/1/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,808,518

Issue Date FY: 2021 ( Subtotal = $2,329,207 )
2021	2021	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	002	8	6/1/2021	NON-COMPETING CONTINUATION	$2,107,499
2021	2021	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	003	8	8/13/2021	SUPPLEMENT FOR EXPANSION	$221,708
2021	2020	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	001	7	4/9/2021	NON-COMPETING CONTINUATION	$0
2021	2020	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	7	1/28/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,329,207

Issue Date FY: 2020 ( Subtotal = $2,107,499 )
2020	2020	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	002	7	7/30/2020	NON-COMPETING CONTINUATION	$2,107,499
2020	2019	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	001	6	5/8/2020	COMPETING CONTINUATION	$0
2020	2018	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	5	4/25/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,107,499

Issue Date FY: 2019 ( Subtotal = $2,107,499 )
2019	2019	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	001	6	7/25/2019	COMPETING CONTINUATION	$2,107,499
2019	2018	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	5	7/19/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,107,499

Issue Date FY: 2018 ( Subtotal = $1,954,982 )
2018	2018	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	5	5/22/2018	NON-COMPETING CONTINUATION	$1,954,982
2018	2018	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	001	5	9/19/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,954,982

Issue Date FY: 2017 ( Subtotal = $1,984,013 )
2017	2017	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	4	5/30/2017	NON-COMPETING CONTINUATION	$1,984,013
														Subtotal = $1,984,013

Issue Date FY: 2016 ( Subtotal = $2,302,777 )
2016	2016	BOISE STATE UNIVERSITY	1910 UNIVERSITY DRIVE	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	3	7/5/2016	NON-COMPETING CONTINUATION	$2,012,176
2016	2016	BOISE STATE UNIVERSITY	1910 UNIVERSITY DRIVE	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	001	3	8/15/2016	SUPPLEMENT FOR EXPANSION	$290,601
														Subtotal = $2,302,777

Issue Date FY: 2015 ( Subtotal = $2,039,509 )
2015	2015	BOISE STATE UNIVERSITY	1910 UNIVERSITY DRIVE	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	2	5/13/2015	NON-COMPETING CONTINUATION	$2,039,509
														Subtotal = $2,039,509

Issue Date FY: 2014 ( Subtotal = $1,996,464 )
2014	2014	BOISE STATE UNIVERSITY	1910 UNIVERSITY DRIVE	BOISE	ID	83725	ADA	USA	Biomedical Research and Research Training	000	1	7/25/2014	NEW	$1,996,464
														Subtotal = $1,996,464

Grand Total All Awards = $22,629,848

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Center of Biomedical Research Excellence in Matrix Biology Phase II

Award Number: P20GM109095

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2014

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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