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Center for Studies of Host Response to Cancer Therapy

Award Number: P20GM109005
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/24/2015
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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Center for Studies of Host Response to Cancer Therapy - PROJECT SUMMARY/ABSTRACT The objectives of the Center for Studies of Host Response to Cancer Therapy are to (1) form a self-sustaining multidisciplinary research center within the University of Arkansas for Medical Sciences (UAMS) to increase the understanding of mechanisms of side effects of cancer therapy, identify methods for early detection, and develop strategies to prevent or treat such side effects and (2) help junior investigators with research programs in this common theme establish themselves as independent scientists. Achieving these goals will create a vibrant, multidisciplinary yet synergistic research environment. To our knowledge, few research centers focus on cancer survivorship, and none take the paradigm-shifting approach of proactively addressing treatment-related toxicities to improve overall cancer treatment outcomes. Specifically, this Center will provide an environment for young investigators to succeed as independent scientists (Aim 1); strengthen the overall research infrastructure at UAMS and the Winthrop P. Rockefeller Cancer Institute (Aim 2); and ensure that the Center becomes self- sustaining (Aim 3). All 6 project leaders recruited to the Center in Phase 1 have built well-funded, productive research programs and close collaborations with each other and several of the pilot project grantees. In preparation for Phase 2, we have recruited 4 promising new/early-stage independent investigators. During Phase 1, the Center focused heavily on radiation therapy. To increase the impact and scope of the Center while retaining its overall theme, project leaders recruited for Phase 2 have a research focus on both radiation and chemotherapy. To increase the likelihood that project leaders will successfully secure independent extramural research funding, individualized mentoring and faculty-development plans will be implemented, and support from an administrative core and 2 research service cores will be integral. To replace project leaders who achieve independence and graduate from COBRE support, a pipeline of new project leaders is ensured through institutional support for recruiting junior faculty combined with a structured pilot project program. Strengthening our interactions with the 5 other COBRE Centers and additional NIH-supported programs that enhance biomedical research on the UAMS and affiliated campuses will also contribute to establishing the Center as a self-sustaining research program that is well-integrated in the institution. The Center's progress will be guided by highly qualified External and Internal Advisory Committees. Strong institutional support combined with active interest from funding agencies in improving uncomplicated cancer cure rates and the quality of life of cancer survivors ensures a high likelihood of success for the Center for Studies of Host Response to Cancer Therapy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $1,471,447 )
2024	2024	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	10	8/5/2024	NON-COMPETING CONTINUATION	$1,471,447
2024	2023	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	9	8/5/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,471,447

Issue Date FY: 2023 ( Subtotal = $2,280,000 )
2023	2023	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	9	8/7/2023	NON-COMPETING CONTINUATION	$2,280,000
														Subtotal = $2,280,000

Issue Date FY: 2022 ( Subtotal = $2,230,535 )
2022	2022	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	002	8	9/26/2022	NON-COMPETING CONTINUATION	$70,946
2022	2022	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	8	7/18/2022	NON-COMPETING CONTINUATION	$2,159,589
2022	2021	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	7	6/14/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,230,535

Issue Date FY: 2021 ( Subtotal = $2,280,000 )
2021	2021	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	003	7	9/10/2021	NON-COMPETING CONTINUATION	$2,280,000
2021	2020	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	6	5/27/2021	COMPETING CONTINUATION	$0
2021	2020	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	002	6	8/11/2021	COMPETING CONTINUATION	$791,002
2021	2019	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	5	8/11/2021	NON-COMPETING CONTINUATION	-$791,002
														Subtotal = $2,280,000

Issue Date FY: 2020 ( Subtotal = $2,280,000 )
2020	2020	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	6	8/17/2020	COMPETING CONTINUATION	$2,280,000
2020	2019	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	5	8/16/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,280,000

Issue Date FY: 2019 ( Subtotal = $2,116,256 )
2019	2019	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	5	3/20/2019	NON-COMPETING CONTINUATION	$2,116,256
														Subtotal = $2,116,256

Issue Date FY: 2018 ( Subtotal = $2,116,256 )
2018	2018	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	4	5/14/2018	NON-COMPETING CONTINUATION	$211,627
2018	2018	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	4	4/6/2018	NON-COMPETING CONTINUATION	$1,904,629
														Subtotal = $2,116,256

Issue Date FY: 2017 ( Subtotal = $2,116,256 )
2017	2017	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	3	3/21/2017	NON-COMPETING CONTINUATION	$1,904,629
2017	2017	UNIVERSITY OF ARKANSAS SYSTEM	4301 W MARKHAM ST SLOT 812 BIO-MED BLDG 1 STE 102	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	001	3	7/10/2017	NON-COMPETING CONTINUATION	$211,627
														Subtotal = $2,116,256

Issue Date FY: 2016 ( Subtotal = $2,116,256 )
2016	2016	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST, M S 545	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	2	3/25/2016	NON-COMPETING CONTINUATION	$2,116,256
														Subtotal = $2,116,256

Issue Date FY: 2015 ( Subtotal = $2,116,256 )
2015	2015	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST, M S 545	LITTLE ROCK	AR	72205	PULASKI	USA	Biomedical Research and Research Training	000	1	6/20/2015	NEW	$2,116,256
														Subtotal = $2,116,256

Grand Total All Awards = $21,123,262

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Center for Studies of Host Response to Cancer Therapy

Award Number: P20GM109005

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/24/2015

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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