Thursday, November 21, 2024 11/21/2024

Center for Modeling Complex Interactons

Award Number: P20GM104420
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY The parent award for this project is the Center for Modeling Complex Interactions (CMCI), which focuses on an approach that can be used to address many biomedical problems. This approach is team-based interdisciplinary research with the goal of integrating modeling into biomedical research projects. CMCI supports modelers by giving them opportunities to integrate into interdisciplinary teams and empiricists by providing them access to relevant modeling expertise. This creates a community and a culture to facilitate interdisciplinary research and enhances the rigor of biomedical research. Following the structure of CMCI, we will build an interdisciplinary team with a shared scientific interest to understand the time and space-dependent roles of type I interferon (IFN-I) responses in controlling respiratory viral infection and limiting inflammation. The proposed research activities include mathematical and computational approaches that will be informed and validated by data generated from cell culture infection studies and mouse lung tissue samples from previous infection studies. An innovative 2D spatiotemporal model of the lung will be built and visualized in virtual reality. By using a tandem mathematical-experimental approach, we will predict temporal dynamics of IFN-I (Aim 1) and uncover unforeseen spatial connections in an augmented reality environment of IFN-I during influenza virus infection (Aim 2). To develop and evaluate the predictive power of these innovative models, we propose forming an interdisciplinary collaboration between scientists of the Departments of Biology, Mathematics, and Virtual Technology and Design at the University of Idaho. The combined expertise in virology, immunology, mathematics, and virtual technology is critical for addressing the complexity of IFN-I roles during influenza virus infection. The knowledge gained through this project will lead to the development of immune-based therapeutics for influenza and other respiratory viral infections. Further, this project will create a community and a culture to facilitate interdisciplinary research at the University of Idaho.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $2,804,280 )
2024	2024	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	004	10	8/12/2024	SUPPLEMENT FOR EXPANSION	$293,197
2024	2024	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	002	10	8/8/2024	NON-COMPETING CONTINUATION	$2,212,500
2024	2024	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	003	10	8/9/2024	SUPPLEMENT FOR EXPANSION	$298,583
2024	2023	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	001	9	8/7/2024	NON-COMPETING CONTINUATION	$0
2024	2023	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	9	11/3/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,804,280

Issue Date FY: 2023 ( Subtotal = $2,478,681 )
2023	2023	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	002	9	9/12/2023	SUPPLEMENT FOR EXPANSION	$266,181
2023	2023	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	001	9	8/17/2023	NON-COMPETING CONTINUATION	$2,212,500
2023	2022	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	8	3/22/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,478,681

Issue Date FY: 2022 ( Subtotal = $2,206,645 )
2022	2022	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DR MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	001	8	9/7/2022	NON-COMPETING CONTINUATION	$2,206,645
2022	2021	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	7	5/11/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,206,645

Issue Date FY: 2021 ( Subtotal = $2,194,934 )
2021	2021	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	003	7	7/13/2021	NON-COMPETING CONTINUATION	$2,194,934
2021	2020	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	001	6	2/2/2021	COMPETING CONTINUATION	$566,258
2021	2020	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	002	6	3/10/2021	COMPETING CONTINUATION	$0
2021	2019	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	5	2/2/2021	NON-COMPETING CONTINUATION	-$566,258
														Subtotal = $2,194,934

Issue Date FY: 2020 ( Subtotal = $2,665,584 )
2020	2020	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	002	6	8/13/2020	COMPETING CONTINUATION	$0
2020	2020	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	003	6	8/14/2020	SUPPLEMENT FOR EXPANSION	$492,598
2020	2020	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	001	6	7/20/2020	COMPETING CONTINUATION	$2,172,986
2020	2019	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	5	7/17/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,665,584

Issue Date FY: 2019 ( Subtotal = $2,112,664 )
2019	2019	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	5	2/14/2019	NON-COMPETING CONTINUATION	$2,112,664
2019	2019	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	001	5	7/8/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,112,664

Issue Date FY: 2018 ( Subtotal = $2,130,681 )
2018	2018	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	003	4	9/14/2018	NON-COMPETING CONTINUATION	$0
2018	2018	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	001	4	5/14/2018	NON-COMPETING CONTINUATION	$213,069
2018	2018	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	4	1/22/2018	NON-COMPETING CONTINUATION	$1,917,612
2018	2018	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	002	4	8/17/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,130,681

Issue Date FY: 2017 ( Subtotal = $2,108,907 )
2017	2017	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	000	3	1/18/2017	NON-COMPETING CONTINUATION	$1,898,016
2017	2017	REGENTS OF THE UNIVERSITY OF IDAHO	875 PERIMETER DRIVE MS 3020	MOSCOW	ID	83844	LATAH	USA	Biomedical Research and Research Training	001	3	7/11/2017	NON-COMPETING CONTINUATION	$210,891
														Subtotal = $2,108,907

Issue Date FY: 2016 ( Subtotal = $2,129,188 )
2016	2016	UNIVERSITY OF IDAHO	Admin Annex Fin Affiars	MOSCOW	ID	83843	LATAH	USA	Biomedical Research and Research Training	000	2	2/26/2016	NON-COMPETING CONTINUATION	$2,129,188
														Subtotal = $2,129,188

Issue Date FY: 2015 ( Subtotal = $2,091,139 )
2015	2015	UNIVERSITY OF IDAHO	Admin Annex Fin Affiars	MOSCOW	ID	83843	LATAH	USA	Biomedical Research and Research Training	000	1	3/13/2015	NEW	$2,091,139
														Subtotal = $2,091,139

Grand Total All Awards = $22,922,703

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Center for Modeling Complex Interactons

Award Number: P20GM104420

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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