Sunday, April 28, 2024 4/28/2024

Discovery of Chemical Probes and Therapeutic Leads, Phase II

Award Number: P20GM104316
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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Project Summary The goal of this Center of Biomedical Research Excellence is to continue our efforts to develop molecular approaches for probing biology, to discover and apply new chemical biology tools for the study of biological pathways associated with disease, and to develop computational approaches for understanding small molecule interactions with complex macromolecular targets. With core strengths in synthesis, biochemistry, engineering and biology, our scientific team will develop new chemical biology tools for understanding the cellular and molecular mechanisms that bacterial pathogens use to survive and replicate inside host cells, new chemical tools and nucleotide analogs to understand the regulation of mRNA demethylation by a ‘methyl eraser’ enzyme and its dysregulation in human cancer, molecularly-defined nanoparticle adjuvants that yield specific immune responses in the lung to advance inhalable vaccine development, and computational approaches to elucidate the mechanisms by which small molecules regulate the structure and function of virus capsids. COBRE funding will be used to recruit two new faculty members who will complement the existing strengths of our center, which will be expanded through competitive pilot grants. In years 4 and 5 of the COBRE, five two- year replacement projects will be funded. Collaboration and resource sharing in the Delaware and national IDeA network will be critical for maximizing our research capacity, core facilities and mentoring network. In Phase II, this COBRE continue to develop unique core facilities that facilitates high throughput synthesis, purification, screening and analysis of chemical probes. Building on the infrastructure established in Phase I, we will support a core facility in Analytical Chemistry, which will provide support for critical core facilities in mass spectrometry, solution NMR and kinetic analysis. The center will also support a Synthesis and Discovery core facility, which will provide custom synthesis services and instrumentation and infrastructure for small molecule synthesis, high throughput catalyst discovery, parallel synthesis, computation and microscopy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	9	2/27/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $3,849,341 )
2023	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	001	9	6/27/2023	NON-COMPETING CONTINUATION	$2,399,995
2023	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	003	9	8/14/2023	SUPPLEMENT FOR EXPANSION	$944,312
2023	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	004	9	9/5/2023	SUPPLEMENT FOR EXPANSION	$248,183
2023	2023	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	002	9	7/13/2023	SUPPLEMENT FOR EXPANSION	$256,851
2023	2022	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	8	4/12/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,849,341

Issue Date FY: 2022 ( Subtotal = $2,599,994 )
2022	2022	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	004	8	6/28/2022	NON-COMPETING CONTINUATION	$2,359,432
2022	2022	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	005	8	6/29/2022	SUPPLEMENT FOR EXPANSION	$240,446
2022	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	7	11/11/2021	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	003	7	5/27/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	001	7	2/3/2022	NON-COMPETING CONTINUATION	$0
2022	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	002	7	4/8/2022	NON-COMPETING CONTINUATION	$0
2022	2018	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	006	5	9/23/2022	NON-COMPETING CONTINUATION	$116
														Subtotal = $2,599,994

Issue Date FY: 2021 ( Subtotal = $3,001,232 )
2021	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	004	7	9/17/2021	SUPPLEMENT FOR EXPANSION	$391,800
2021	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	003	7	9/1/2021	SUPPLEMENT FOR EXPANSION	$250,000
2021	2021	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	002	7	8/12/2021	NON-COMPETING CONTINUATION	$2,359,432
2021	2020	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	001	6	6/13/2021	COMPETING CONTINUATION	$7,021
2021	2018	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	5	6/13/2021	NON-COMPETING CONTINUATION	-$7,021
														Subtotal = $3,001,232

Issue Date FY: 2020 ( Subtotal = $2,664,841 )
2020	2020	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	002	6	8/10/2020	COMPETING CONTINUATION	$2,349,582
2020	2020	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	003	6	8/21/2020	SUPPLEMENT FOR EXPANSION	$315,259
2020	2018	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	5	6/24/2020	NON-COMPETING CONTINUATION	$0
2020	2018	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	001	5	8/9/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,664,841

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2018	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	001	5	3/11/2019	NON-COMPETING CONTINUATION	$0
2019	2018	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	5	12/7/2018	NON-COMPETING CONTINUATION	$0
2019	2018	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	002	5	9/20/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $2,074,710 )
2018	2018	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	5	5/31/2018	NON-COMPETING CONTINUATION	$2,074,710
2018	2018	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	001	5	9/19/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,074,710

Issue Date FY: 2017 ( Subtotal = $2,141,350 )
2017	2017	UNIVERSITY OF DELAWARE	220 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	4	5/31/2017	NON-COMPETING CONTINUATION	$2,141,350
														Subtotal = $2,141,350

Issue Date FY: 2016 ( Subtotal = $2,224,280 )
2016	2016	UNIVERSITY OF DELAWARE	210 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	3	6/22/2016	NON-COMPETING CONTINUATION	$2,224,280
														Subtotal = $2,224,280

Issue Date FY: 2015 ( Subtotal = $2,281,256 )
2015	2015	UNIVERSITY OF DELAWARE	210 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	2	7/20/2015	NON-COMPETING CONTINUATION	$2,281,256
														Subtotal = $2,281,256

Issue Date FY: 2014 ( Subtotal = $2,523,825 )
2014	2014	UNIVERSITY OF DELAWARE	210 HULLIHEN HALL	NEWARK	DE	19716	NEW CASTLE	USA	Biomedical Research and Research Training	000	1	8/22/2014	NEW	$2,523,825
														Subtotal = $2,523,825

Grand Total All Awards = $23,360,829

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Discovery of Chemical Probes and Therapeutic Leads, Phase II

Award Number: P20GM104316

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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