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CardioPulmonary Vascular Biology COBRE

Award Number: P20GM103652
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2013
PERIOD OF PERFORMANCE END DATE: 05/31/2025

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CardioPulmonary Vascular Biology COBRE - The vision of the CardioPulmonary Vascular Biology Center of Biomedical Research Excellence (CPVB COBRE) is to advance understanding of vascular diseases affecting the pulmonary and cardiovascular systems. This vision will be accomplished through research performed by a multidisciplinary group of outstanding investigators who are using cutting edge tools to understand the pathobiology of vascular diseases. In this phase II application we seek to renew funding for a second 5 years. We will continue the research partnership of three collaborating institutions—Ocean State Research Institute (OSRI), the Rhode Island Hospital, and Brown University. The applicant institution, OSRI, is the research and education nonprofit associated with the Providence VA Medical Center, a teaching hospital affiliated with the Warren Alpert Medical School of Brown University. In Phase I, the CPVB COBRE supported development of a community of researchers, provided career development and research skill training, and stimulated new research collaborations among the investigators, mentors, and other faculty. Strong institutional support brought expert visitors to the center, resulting in additional research collaborations. Teaching and mentoring activities of CPVB COBRE investigators enhanced knowledge of vascular biology among undergraduate and graduate students, as well as postdoctoral trainees and junior faculty. CPVB COBRE investigators have competed successfully for $7.61 million in research funding during Phase I. Similar approaches will be used during Phase II, and five outstanding junior investigators have been identified who bring complementary backgrounds, skills, and research interests. New areas of research will be pursued using innovative approaches that expand the scope of COBRE technical resources. Thus, the CPVB COBRE will continue to broaden the scope and depth of vascular biology research at the partnering Rhode Island institutions. The CardioPulmonary Vascular Biology COBRE proposes the following specific aims for Phase II of funding: (1) Create a multidisciplinary group of investigators in studies of vascular injury and repair. (2) Provide research support, protected time, and mentoring to enable junior investigators to become independent scientists and provide robust support for research career and professional development. (3) Expand the CardioPulmonary Vascular Biology Center into new research areas and thereby enhance and broaden vascular biology research at collaborating institutions. (4) Provide services supporting vascular biology research and develop a self-sustaining Cell/Organ Core. Accomplishment of these aims will result in a strengthened and broadened CardioPulmonary Vascular Biology COBRE that will be the basis for new interdisciplinary scientific collaborations, significant contributions to understanding of pulmonary and cardiovascular diseases, and improvements in the health of the citizens of Rhode Island and the nation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	OCEAN STATE RESEARCH INSTITUTE INC	830 CHALKSTONE AVE	NORTH PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	000	10	5/20/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $2,025,917 )
2022	2022	OCEAN STATE RESEARCH INSTITUTE, INC.	830 CHALKSTONE AVE BLDG 35	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	002	10	9/23/2022	NON-COMPETING CONTINUATION	$0
2022	2022	OCEAN STATE RESEARCH INSTITUTE, INC.	830 CHALKSTONE AVE BLDG 35	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	001	10	5/26/2022	NON-COMPETING CONTINUATION	$2,025,917
2022	2021	OCEAN STATE RESEARCH INSTITUTE, INC.	830 CHALKSTONE AVE BLDG 35	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	000	9	2/25/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,025,917

Issue Date FY: 2021 ( Subtotal = $2,067,372 )
2021	2021	OCEAN STATE RESEARCH INSTITUTE, INC.	830 CHALKSTONE AVE BLDG 35	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	002	9	6/24/2021	NON-COMPETING CONTINUATION	$2,067,372
2021	2020	OCEAN STATE RESEARCH INSTITUTE, INC.	830 CHALKSTONE AVE BLDG 35	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	001	8	5/10/2021	NON-COMPETING CONTINUATION	$0
2021	2020	OCEAN STATE RESEARCH INSTITUTE, INC.	830 CHALKSTONE AVE BLDG 35	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	000	8	4/2/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,067,372

Issue Date FY: 2020 ( Subtotal = $2,105,849 )
2020	2020	OCEAN STATE RESEARCH INSTITUTE, INC.	830 CHALKSTONE AVE BLDG 35	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	001	8	6/22/2020	NON-COMPETING CONTINUATION	$2,105,849
2020	2019	OCEAN STATE RESEARCH INSTITUTE, INC.	830 CHALKSTONE AVE BLDG 35	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	000	7	3/19/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,105,849

Issue Date FY: 2019 ( Subtotal = $2,463,939 )
2019	2019	OCEAN STATE RESEARCH INSTITUTE, INC.	830 CHALKSTONE AVE BLDG 35	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	003	7	7/17/2019	NON-COMPETING CONTINUATION	$2,143,839
2019	2019	OCEAN STATE RESEARCH INSTITUTE, INC.	830 CHALKSTONE AVE BLDG 35	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	004	7	8/22/2019	SUPPLEMENT FOR EXPANSION	$320,100
2019	2018	OCEAN STATE RESEARCH INSTITUTE, INC.	830 CHALKSTONE AVE BLDG 35	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	002	6	2/11/2019	COMPETING CONTINUATION	$0
2019	2018	OCEAN STATE RESEARCH INSTITUTE, INC.	830 CHALKSTONE AVE BLDG 35	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	001	6	1/31/2019	COMPETING CONTINUATION	$1,013,290
2019	2017	OCEAN STATE RESEARCH INSTITUTE, INC.	830 CHALKSTONE AVE BLDG 35	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	000	5	1/31/2019	NON-COMPETING CONTINUATION	-$1,013,290
														Subtotal = $2,463,939

Issue Date FY: 2018 ( Subtotal = $2,219,092 )
2018	2018	OCEAN STATE RESEARCH INSTITUTE, INC.	830 CHALKSTONE AVE BLDG 35	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	000	6	7/20/2018	COMPETING CONTINUATION	$2,219,092
2018	2017	OCEAN STATE RESEARCH INSTITUTE, INC.	830 CHALKSTONE AVE BLDG 35	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	001	5	8/15/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,219,092

Issue Date FY: 2017 ( Subtotal = $2,046,434 )
2017	2017	OCEAN STATE RESEARCH INSTITUTE, INC.	830 CHALKSTONE AVE BLDG 35	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	002	5	6/15/2017	NON-COMPETING CONTINUATION	$2,046,434
2017	2016	OCEAN STATE RESEARCH INSTITUTE, INC.	830 CHALKSTONE AVE BLDG 35	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	001	4	11/3/2016	EXTENSION WITH OR WITHOUT FUNDS	$744,592
2017	2015	OCEAN STATE RESEARCH INSTITUTE, INC.	830 CHALKSTONE AVE BLDG 35	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	000	3	11/3/2016	NON-COMPETING CONTINUATION	-$744,592
														Subtotal = $2,046,434

Issue Date FY: 2016 ( Subtotal = $2,064,137 )
2016	2016	OCEAN STATE RESEARCH INSTITUTE INC	830 CHALKSTONE AVENUE	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	000	4	6/16/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,064,137
														Subtotal = $2,064,137

Issue Date FY: 2015 ( Subtotal = $2,079,394 )
2015	2015	OCEAN STATE RESEARCH INSTITUTE INC	830 CHALKSTONE AVENUE	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	000	3	6/8/2015	NON-COMPETING CONTINUATION	$2,079,394
														Subtotal = $2,079,394

Issue Date FY: 2014 ( Subtotal = $2,254,674 )
2014	2014	OCEAN STATE RESEARCH INSTITUTE INC	830 CHALKSTONE AVENUE	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	001	2	5/28/2014	NON-COMPETING CONTINUATION	$2,039,892
2014	2014	OCEAN STATE RESEARCH INSTITUTE INC	830 CHALKSTONE AVENUE	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	002	2	8/25/2014	NON-COMPETING CONTINUATION	$60,151
2014	2013	OCEAN STATE RESEARCH INSTITUTE INC	830 CHALKSTONE AVENUE	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	000	1	5/22/2014	NEW	$109,680
2014	2013	OCEAN STATE RESEARCH INSTITUTE INC	830 CHALKSTONE AVENUE	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	003	1	8/29/2014	NEW	$44,951
														Subtotal = $2,254,674

Issue Date FY: 2013 ( Subtotal = $2,006,819 )
2013	2013	OCEAN STATE RESEARCH INSTITUTE INC	830 CHALKSTONE AVENUE	PROVIDENCE	RI	02908	PROVIDENCE	USA	Biomedical Research and Research Training	000	1	9/17/2013	NEW	$2,006,819
														Subtotal = $2,006,819

Grand Total All Awards = $21,333,627

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CardioPulmonary Vascular Biology COBRE

Award Number: P20GM103652

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2013

PERIOD OF PERFORMANCE END DATE: 05/31/2025

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