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Center of Biomedical Research Excellence in Pathogen Host Interactions

Award Number: P20GM103646
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2013
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Center of Biomedical Research Excellence in Pathogen Host Interactions - Overall Abstract The Phase I COBRE at Mississippi State University (MSU) has catalyzed a transformation in the biomedical research enterprise, particularly in the research focus area of the COBRE, pathogen-host interactions. In the CVM Basic Sciences Department, where most COBRE investigators worked, the research culture has changed; 19 of 20 faculty members now have competitive extramural funding. Furthermore, the total NIH funding amount at Mississippi State University has increased from about $1.4 million in 2012 (just before the Phase I COBRE began) to about $5.4 million in 2016 (year 4 of the Phase I COBRE). Two of our Phase I investigators have graduated to independent status, and all have obtained significant levels of competitive extramural funding. In fact, these two independent Phase I investigators will serve on the Leadership Team in Phase II, which will continue relationships between Phase I and Phase II investigators to build functional teams that will be competitive for collaborative funding efforts. Continuing the transformation of biomedical research at MSU to yield a self-sustaining high level research enterprise is the goal of the Phase II COBRE described in this application. We have identified 5 excellent investigators (two of whom were hired during Phase I) to lead research projects in the Phase II COBRE. The projects include sufficient commonality to allow synergy, and all are novel and have the potential to open new avenues of investigation. For example, two projects focus on vector borne diseases, three projects investigate the role of microbial metabolic adaptations in virulence, and two projects involve Staphylococcus aureus. One of the most positive characteristics of our investigators is the spontaneous development of collaborations between Phase I and Phase II investigators, which has occurred even before the beginning of Phase II. Plans for Phase II take advantage of this by deliberately encouraging continued interactions between Phase I and Phase II investigators both in mentoring and in research collaboration. Each investigator in Phase II has identified a distinguished scientist who is a leader in his/her field of study to serve as an external mentor. Internal mentors (from MSU) will serve as advisors in both scientific areas and in grant writing. All members of the distinguished External Advisory Committee from Phase I have agreed to serve in the same role in Phase II. With funds from Phase I, physical facilities and research infrastructure have been substantially improved by purchase of major equipment, renovation of the HVAC system of 4 labs, and addition of 6 Biological Safety Cabinets. The support of MSU for research in pathogen-host interactions is also illustrated by the university’s substantial investment to acquire a BSL-3 modular lab (1200 square feet with 3 separate labs), which has been commissioned and should be operational by the summer of 2018. A major user will be one of our COBRE Phase I investigators. The proposed Phase II COBRE will allow initiatives begun in Phase I to continue and establish a critical mass of well-funded investigators who can conduct high impact research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$132,580 )
2026	2022	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	000	10	1/14/2026	NON-COMPETING CONTINUATION	-$132,580
														Subtotal = -$132,580

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	000	10	8/6/2024	NON-COMPETING CONTINUATION	$0
2024	2022	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	001	10	9/24/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	000	10	4/19/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $2,140,849 )
2022	2022	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	002	10	9/16/2022	NON-COMPETING CONTINUATION	$2,140,849
2022	2021	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	001	9	2/8/2022	NON-COMPETING CONTINUATION	$0
2022	2021	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	000	9	1/10/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,140,849

Issue Date FY: 2021 ( Subtotal = $2,144,923 )
2021	2021	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	002	9	8/16/2021	NON-COMPETING CONTINUATION	$2,144,923
2021	2020	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	000	8	3/8/2021	NON-COMPETING CONTINUATION	$0
2021	2020	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	001	8	6/29/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,144,923

Issue Date FY: 2020 ( Subtotal = $2,148,925 )
2020	2020	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	001	8	9/11/2020	NON-COMPETING CONTINUATION	$2,148,925
2020	2019	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	000	7	4/13/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,148,925

Issue Date FY: 2019 ( Subtotal = $2,146,848 )
2019	2019	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	003	7	8/28/2019	NON-COMPETING CONTINUATION	$2,146,848
2019	2018	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	002	6	4/23/2019	COMPETING CONTINUATION	$625,161
2019	2017	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	001	5	4/23/2019	SUPPLEMENT FOR EXPANSION	-$311,902
2019	2017	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	000	5	4/23/2019	NON-COMPETING CONTINUATION	-$313,259
														Subtotal = $2,146,848

Issue Date FY: 2018 ( Subtotal = $2,131,604 )
2018	2018	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	002	6	8/31/2018	COMPETING CONTINUATION	$2,131,604
2018	2017	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	001	5	8/30/2018	SUPPLEMENT FOR EXPANSION	$0
2018	2017	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	000	5	8/30/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,131,604

Issue Date FY: 2017 ( Subtotal = $2,079,054 )
2017	2017	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	003	5	9/11/2017	SUPPLEMENT FOR EXPANSION	$311,902
2017	2017	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	002	5	5/26/2017	NON-COMPETING CONTINUATION	$1,767,152
2017	2016	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	001	4	11/29/2016	EXTENSION WITH OR WITHOUT FUNDS	$324,688
2017	2015	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	000	3	11/29/2016	NON-COMPETING CONTINUATION	-$324,688
														Subtotal = $2,079,054

Issue Date FY: 2016 ( Subtotal = $1,895,489 )
2016	2016	MISSISSIPPI STATE UNIVERSITY	P.O. BOX 5227	STATE COLLEGE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	000	4	6/21/2016	EXTENSION WITH OR WITHOUT FUNDS	$1,895,489
														Subtotal = $1,895,489

Issue Date FY: 2015 ( Subtotal = $2,016,391 )
2015	2015	MISSISSIPPI STATE UNIVERSITY	P.O. BOX 5227	STATE COLLEGE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	000	3	7/31/2015	NON-COMPETING CONTINUATION	$2,016,391
														Subtotal = $2,016,391

Issue Date FY: 2014 ( Subtotal = $2,006,213 )
2014	2014	MISSISSIPPI STATE UNIVERSITY	P.O. BOX 5227	STATE COLLEGE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	000	2	7/22/2014	NON-COMPETING CONTINUATION	$2,006,213
														Subtotal = $2,006,213

Issue Date FY: 2013 ( Subtotal = $2,403,396 )
2013	2013	MISSISSIPPI STATE UNIVERSITY	P.O. BOX 5227	STATE COLLEGE	MS	39762	OKTIBBEHA	USA	Biomedical Research and Research Training	000	1	9/26/2013	NEW	$2,403,396
														Subtotal = $2,403,396

Grand Total All Awards = $20,981,112

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Center of Biomedical Research Excellence in Pathogen Host Interactions

Award Number: P20GM103646

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2013

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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