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COBRE Phase 2: Center for Neuroplasticity at the University of Puerto Rico

Award Number: P20GM103642
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2023

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COBRE Phase 2: Center for Neuroplasticity at the University of Puerto Rico - Project Abstract The main goal of this application is to purchase four new pieces of equipment to enhance the UPR COBRE Center for Neuroplasticity (UPR-CCfN) and the Neuroimaging and Electrophysiological Facility (NIEF, https://www.nief-upr.com/) at the Molecular Science Research Center (MSRC, (http://cicim.upr.edu/). The UPR-CCfN is a collaborative effort between researchers from the Medical Sciences Campus and the Department of Biology at the Rio Piedras Campus. Its goal is to understand a wide range of neurological problems, including deciphering the neural circuits that control behavior, the origins of neural and mental health disorders such as autism, PTSD, dementia, elucidating the molecular basis for alcohol neuroadaptation, addiction, and neuroprotection. This supplemental application is the result of the collaborative efforts of 22 scientists to improve our COBRE UPR-CCfN. The increased demands on the variety of services and applications that must be provided by the NIEF have greatly increased based on its significant growth of users as well as the interdisciplinary nature of the science. We propose purchasing the following four new pieces of equipment: (1) Nikon Eclipse LV100N Polarized microscope, (2) Cytiva AKTA Purifier 100 FPLC System (3) LI-COR Odyssey Western Blot system and (4) QuantStudio 3 PRO-Real Time PRC system. After carefully evaluating various commercial sources on the market, we have determined these four instruments are ideal for the UPR-CCfN. These instruments will also impact a list of new investigators recently hired at the UPR-CCfN, as well as new grant projects that include biologically relevant studies such as HIV-associated dementia studies, lipidomic analysis of ion channels detergent-complexes to improve crystallization, schistosomiasis neuropeptide characterization, characterization of a neuroprotective nutritional supplement against ischemic stroke, and natural product analogs design. The proposed instruments will catalyze the multidisciplinary collaborations between researchers at the CCfN and other institutions within and outside of Puerto Rico. Another important aspect of the NIEF's development is the services the facility will provide to researchers being recruited shortly to pursue basic and biomedical-relevant projects at the UPR. Furthermore, the upgraded NIEF will optimize faculty, postdoctoral fellows, and graduate student expertise and skills so vital for competitive research. Finally, these instruments will greatly impact the development of the large student population currently supported by NIH, NASA, and NSF- sponsored fellowships or assistantships.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$439,459 )
2024	2023	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	B622 MAIN BUILDING FLR 6	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	001	10	12/1/2023	SUPPLEMENT FOR EXPANSION	-$249,988
2024	2022	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	B622 MAIN BUILDING FLR 6	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	000	10	12/1/2023	NON-COMPETING CONTINUATION	-$189,471
														Subtotal = -$439,459

Issue Date FY: 2023 ( Subtotal = $249,988 )
2023	2023	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	B622 MAIN BUILDING FLR 6	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	000	10	6/15/2023	SUPPLEMENT FOR EXPANSION	$249,988
														Subtotal = $249,988

Issue Date FY: 2022 ( Subtotal = $1,988,498 )
2022	2022	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	000	10	7/13/2022	NON-COMPETING CONTINUATION	$1,988,498
														Subtotal = $1,988,498

Issue Date FY: 2021 ( Subtotal = $2,001,266 )
2021	2021	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	001	9	7/12/2021	NON-COMPETING CONTINUATION	$2,001,266
2021	2020	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	000	8	5/18/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,001,266

Issue Date FY: 2020 ( Subtotal = $2,121,165 )
2020	2020	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	000	8	7/7/2020	NON-COMPETING CONTINUATION	$2,121,165
														Subtotal = $2,121,165

Issue Date FY: 2019 ( Subtotal = $2,020,514 )
2019	2019	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	003	7	6/19/2019	NON-COMPETING CONTINUATION	$2,020,514
2019	2018	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	002	6	4/10/2019	COMPETING CONTINUATION	$0
2019	2018	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	001	6	11/29/2018	COMPETING CONTINUATION	$1,120,311
2019	2017	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	000	5	11/29/2018	NON-COMPETING CONTINUATION	-$1,120,311
														Subtotal = $2,020,514

Issue Date FY: 2018 ( Subtotal = $1,426,872 )
2018	2018	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	000	6	7/16/2018	COMPETING CONTINUATION	$1,426,872
2018	2018	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	001	6	7/31/2018	COMPETING CONTINUATION	$0
														Subtotal = $1,426,872

Issue Date FY: 2017 ( Subtotal = $2,032,800 )
2017	2017	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	002	5	6/13/2017	NON-COMPETING CONTINUATION	$2,032,800
2017	2016	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	001	4	11/9/2016	EXTENSION WITH OR WITHOUT FUNDS	$1,761,126
2017	2015	UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS	MAIN BLDG FLR 6 B-622	SAN JUAN	PR	00935	SAN JUAN	USA	Biomedical Research and Research Training	000	3	11/9/2016	NON-COMPETING CONTINUATION	-$1,761,126
														Subtotal = $2,032,800

Issue Date FY: 2016 ( Subtotal = $2,077,652 )
2016	2016	UNIVERSITY OF PUERTO RICO - MEDICAL SCIENCE CAMPUS	POST OFFICE BOX 365067	SAN JUAN	PR			USA	Biomedical Research and Research Training	000	4	6/21/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,077,652
														Subtotal = $2,077,652

Issue Date FY: 2015 ( Subtotal = $2,093,994 )
2015	2015	UNIVERSITY OF PUERTO RICO - MEDICAL SCIENCE CAMPUS	POST OFFICE BOX 365067	SAN JUAN	PR			USA	Biomedical Research and Research Training	000	3	7/1/2015	NON-COMPETING CONTINUATION	$2,093,994
														Subtotal = $2,093,994

Issue Date FY: 2014 ( Subtotal = $2,135,856 )
2014	2014	UNIVERSITY OF PUERTO RICO - MEDICAL SCIENCE CAMPUS	POST OFFICE BOX 365067	SAN JUAN	PR			USA	Biomedical Research and Research Training	000	2	8/14/2014	NON-COMPETING CONTINUATION	$2,135,856
														Subtotal = $2,135,856

Issue Date FY: 2013 ( Subtotal = $2,472,670 )
2013	2013	UNIVERSITY OF PUERTO RICO - MEDICAL SCIENCE CAMPUS	POST OFFICE BOX 365067	SAN JUAN	PR			USA	Biomedical Research and Research Training	000	1	6/21/2013	NEW	$2,472,670
														Subtotal = $2,472,670

Grand Total All Awards = $20,181,816

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COBRE Phase 2: Center for Neuroplasticity at the University of Puerto Rico

Award Number: P20GM103642

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2023

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